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Page 1
Molecular evolution of SARS-CoV-2 from December 2019 to August 2022.
Wolf JM, Wolf LM, Bello GL, Maccari JG, Nasi LA. Wolf JM, et al. J Med Virol. 2023 Jan;95(1):e28366. doi: 10.1002/jmv.28366. J Med Virol. 2023. PMID: 36458547 Free PMC article. Review.
Between December 2019 and June 2020, 11 clades were detected (20I [Alpha] and 19A, 19B, 20B, 20C, 20A, 20D, 20E [EU1], 20F, 20H [Beta]). From July to December 2020, 4 clades were identified (20J [Gamma, V3], 21 C [Epsilon], 21D [Eta], and 21G [Lambda]). ...
Between December 2019 and June 2020, 11 clades were detected (20I [Alpha] and 19A, 19B, 20B, 20C, 20A, 20D, 20E [EU1], 20F, 20 …
SARS-CoV-2 genome variations and evolution patterns in Egypt: a multi-center study.
Jalal D, Elzayat MG, El-Shqanqery HE, Diab AA, Yahia A, Samir O, Bakry U, Amer K, ElNaqeeb M, Hassan W, Talat HS, Farawela HM, Hamdy MS, Soliman MS, El Sissy MH, Ezzelarab MH, El Khateeb SM, Soliman LH, Haddad SE, Hatem A, Ismail MS, Hossam M, Mansour T, Shalaby L, Soliman S, Hassan R, Hammad M, Abdo I, Magdeldin S, ElHaddad A, Abouelnaga S, Sayed AA. Jalal D, et al. Sci Rep. 2022 Aug 25;12(1):14511. doi: 10.1038/s41598-022-18644-4. Sci Rep. 2022. PMID: 36008511 Free PMC article.
According to Nextstrain clades, most of our sequenced samples belonged to clades 20A and 20D, which in addition to clade 20B were present from the beginning of sample collection in May 2020. ...
According to Nextstrain clades, most of our sequenced samples belonged to clades 20A and 20D, which in addition to clade 20B w …
Association of the Interleukin 1B-31*C Proinflammatory Allele with the Severity of COVID-19 Patients: A Preliminary Report.
Galán-Huerta KA, Zamora-Márquez MA, Flores-Pérez RO, Bocanegra-Ibarias P, Salas-Treviño D, Rivas-Estilla AMG, Flores-Treviño S, Lozano-Sepúlveda SA, Martínez-Acuña N, Camacho-Ortiz A, Pérez Alba E, Arellanos-Soto D, Nuzzolo-Shihadeh L, Garza-González E. Galán-Huerta KA, et al. Viral Immunol. 2023 May;36(4):241-249. doi: 10.1089/vim.2022.0143. Epub 2023 Feb 17. Viral Immunol. 2023. PMID: 36800236
The IL1B-31 *C-IL-4-590 *T haplotype increased the risk of ICU admission (OR = 2.53, 95% CI = 1.02-6.25, p = 0.047). The 42 SARS-CoV-2 genomes sequenced belonged to four clades, 20A-20D. No association was detected between SARS-CoV-2 clades and ICU admission or deat …
The IL1B-31 *C-IL-4-590 *T haplotype increased the risk of ICU admission (OR = 2.53, 95% CI = 1.02-6.25, p = 0.047). The 42 SARS-CoV-2 genom …
Structural Optimization of the Natural Product: Discovery of Almazoles C-D and Their Derivatives as Novel Antiviral and Anti-phytopathogenic Fungus Agents.
Yuan M, Tian Z, Yin X, Yuan X, Gao J, Yuan W, Lu A, Wang Z, Li L, Wang Q. Yuan M, et al. J Agric Food Chem. 2022 Dec 21;70(50):15693-15702. doi: 10.1021/acs.jafc.2c05898. Epub 2022 Dec 8. J Agric Food Chem. 2022. PMID: 36479881
The results of anti-tobacco mosaic virus (anti-TMV) activity showed that almazoles C-D and their derivatives had good anti-TMV activities. Compounds 6, 15, 16a, 16b, 16g, 16l, 16n, 20a, 20d, 20i, and 20n exhibited better anti-TMV activities than the commercial antiv …
The results of anti-tobacco mosaic virus (anti-TMV) activity showed that almazoles C-D and their derivatives had good anti-TMV activities. C …
Synthesis and evaluation of the HIF-1α inhibitory activity of 3(5)-substituted-4-(quinolin-4-yl)- and 4-(2-phenylpyridin-4-yl)pyrazoles as inhibitors of ALK5.
Li YW, Li XY, Li S, Zhao LM, Ma J, Piao HR, Jiang Z, Jin CH, Jin X. Li YW, et al. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126822. doi: 10.1016/j.bmcl.2019.126822. Epub 2019 Nov 17. Bioorg Med Chem Lett. 2020. PMID: 31810777
Six series of 3(5)-(6-methylpyridin-2-yl)-4-(quinolin-4-yl)pyrazoles (11a-d, 12a-d, and 18a-d) and 3(5)-(6-methylpyridin-2-yl)-4-(2-phenyl-pyridin-4-yl)pyrazoles (19a-d, 20a-d, and 21a-d) were synthesized and evaluated for activin receptor-like kinase 5 (ALK5) and HIF-1alp …
Six series of 3(5)-(6-methylpyridin-2-yl)-4-(quinolin-4-yl)pyrazoles (11a-d, 12a-d, and 18a-d) and 3(5)-(6-methylpyridin-2-yl)-4-(2-phenyl-p …
Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens.
Rashamuse TJ, Harrison AT, Mosebi S, van Vuuren S, Coyanis EM, Bode ML. Rashamuse TJ, et al. Bioorg Med Chem. 2020 Jan 1;28(1):115210. doi: 10.1016/j.bmc.2019.115210. Epub 2019 Nov 9. Bioorg Med Chem. 2020. PMID: 31753802
The compounds obtained were biologically evaluated in an AlphaScreen HIV-1 IN-LEDGF/p75 inhibition assay with six imidazole-based compounds (16c, 16f, 17c, 17f, 20a and 20d) displaying more than 50% inhibition at 10 M, with IC(50) values ranging from 7.0 to 30.4 M. …
The compounds obtained were biologically evaluated in an AlphaScreen HIV-1 IN-LEDGF/p75 inhibition assay with six imidazole-based compounds …
Genomic and Phylogenetic Characterisation of SARS-CoV-2 Genomes Isolated in Patients from Lambayeque Region, Peru.
Aguilar-Martinez SL, Sandoval-Peña GA, Molina-Mora JA, Tsukayama-Cisneros P, Díaz-Vélez C, Aguilar-Gamboa FR, Bonilla-Aldana DK, Rodriguez-Morales AJ. Aguilar-Martinez SL, et al. Trop Med Infect Dis. 2024 Feb 11;9(2):46. doi: 10.3390/tropicalmed9020046. Trop Med Infect Dis. 2024. PMID: 38393135 Free PMC article.
RESULTS: It was determined that during the period from December 2020 to January 2021, the lineages s C.14, C.33, B.1.1.485, B.1.1, B.1.1.1, and B.1.111 circulated, with lineage C.14 being the most predominant at 76.7% (n = 23/30). These lineages were classified in clade 20D …
RESULTS: It was determined that during the period from December 2020 to January 2021, the lineages s C.14, C.33, B.1.1.485, B.1.1, B.1.1.1, …
Genome sequence diversity of SARS-CoV-2 in Serbia: insights gained from a 3-year pandemic study.
Novkovic M, Banovic Djeri B, Ristivojevic B, Knezevic A, Jankovic M, Tanasic V, Radojicic V, Keckarevic D, Vidanovic D, Tesovic B, Skakic A, Tolinacki M, Moric I, Djordjevic V. Novkovic M, et al. Front Microbiol. 2024 Feb 27;15:1332276. doi: 10.3389/fmicb.2024.1332276. eCollection 2024. Front Microbiol. 2024. PMID: 38476954 Free PMC article.
The samples were assigned to sixteen SARS-CoV-2 Nextstrain clades: 20A, 20B, 20C, 20D, 20E, 20G, 20I, 21J, 21K, 21L, 22A, 22B, 22C, 22D, 22E, and 22F and six different Omicron recombinants (XZ, XAZ, XAS, XBB, XBF, and XBK). ...
The samples were assigned to sixteen SARS-CoV-2 Nextstrain clades: 20A, 20B, 20C, 20D, 20E, 20G, 20I, 21J, 21K, 21L, 22A, 22B, …
Emergence of Novel SARS-CoV-2 variants in India: second wave.
Adiga R, Nayak V. Adiga R, et al. J Infect Dev Ctries. 2021 Nov 30;15(11):1578-1583. doi: 10.3855/jidc.15484. J Infect Dev Ctries. 2021. PMID: 34898481 Free article.
RESULTS: 21A or B.1.617 or delta was the most prevalent lineage in India accounting for 67.7% of the genomes. Next important clades were 20A, 20B and 20I accounting for 23.6%, 11.8% and 12.1% respectively collected between January 2021 and April 2021. The remaining sequenc …
RESULTS: 21A or B.1.617 or delta was the most prevalent lineage in India accounting for 67.7% of the genomes. Next important clades were …
Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.
Makrantoni V, Corbishley SJ, Rachidi N, Morrice NA, Robinson DA, Stark MJ. Makrantoni V, et al. PLoS One. 2014 Feb 18;9(2):e89399. doi: 10.1371/journal.pone.0089399. eCollection 2014. PLoS One. 2014. PMID: 24558497 Free PMC article.
Here we have identified multiple sites of CPC autophosphorylation on yeast Sli15 that are located within its central microtubule-binding domain and examined the functional significance of their phosphorylation by Ipl1 through mutation of these sites, either to non-phosphorylatabl …
Here we have identified multiple sites of CPC autophosphorylation on yeast Sli15 that are located within its central microtubule-binding dom …
19 results