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Page 1
A designed photoenzyme for enantioselective [2+2] cycloadditions.
Trimble JS, Crawshaw R, Hardy FJ, Levy CW, Brown MJB, Fuerst DE, Heyes DJ, Obexer R, Green AP. Trimble JS, et al. Among authors: brown mjb. Nature. 2022 Nov;611(7937):709-714. doi: 10.1038/s41586-022-05335-3. Epub 2022 Sep 21. Nature. 2022. PMID: 36130727
Engineered Biocatalyst for Enantioselective Hydrazone Reduction.
Hutton AE, Zhao F, Ho E, Domenech J, Harawa V, Brown MJB, Grogan G, Clayman PD, Turner NJ, Green AP. Hutton AE, et al. Among authors: brown mjb. Angew Chem Int Ed Engl. 2025 Jun 24;64(26):e202424350. doi: 10.1002/anie.202424350. Epub 2025 Apr 30. Angew Chem Int Ed Engl. 2025. PMID: 40244857 Free PMC article.
1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3.
Christopher JA, Atkinson FL, Bax BD, Brown MJ, Champigny AC, Chuang TT, Jones EJ, Mosley JE, Musgrave JR. Christopher JA, et al. Among authors: brown mj. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2230-4. doi: 10.1016/j.bmcl.2009.02.098. Epub 2009 Feb 28. Bioorg Med Chem Lett. 2009. PMID: 19303774
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.
Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ. Blackie JA, et al. Among authors: brown mj. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70. doi: 10.1016/s0960-894x(03)00058-1. Bioorg Med Chem Lett. 2003. PMID: 12643913
The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.
Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Elliott RL, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ, Whittaker CM. Blackie JA, et al. Among authors: brown mj. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2603-6. doi: 10.1016/s0960-894x(02)00473-0. Bioorg Med Chem Lett. 2002. PMID: 12182870