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1,483 results

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Page 1
Consensus statement: Academy of Nutrition and Dietetics and American Society for Parenteral and Enteral Nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition).
White JV, Guenter P, Jensen G, Malone A, Schofield M; Academy Malnutrition Work Group; A.S.P.E.N. Malnutrition Task Force; A.S.P.E.N. Board of Directors. White JV, et al. JPEN J Parenter Enteral Nutr. 2012 May;36(3):275-83. doi: 10.1177/0148607112440285. JPEN J Parenter Enteral Nutr. 2012. PMID: 22535923
The Academy of Nutrition and Dietetics (Academy) and the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) recommend that a standardized set of diagnostic characteristics be used to identify and document adult malnutrition in routine clinical practice. ...
The Academy of Nutrition and Dietetics (Academy) and the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) recommend …
2-Oxoglutarate-Dependent Oxygenases.
Islam MS, Leissing TM, Chowdhury R, Hopkinson RJ, Schofield CJ. Islam MS, et al. Annu Rev Biochem. 2018 Jun 20;87:585-620. doi: 10.1146/annurev-biochem-061516-044724. Epub 2018 Mar 1. Annu Rev Biochem. 2018. PMID: 29494239 Review.
In animals, these comprise hydroxylations and N-demethylations proceeding via hydroxylation; in plants and microbes, they catalyze a wider range including ring formations, rearrangements, desaturations, and halogenations. ...
In animals, these comprise hydroxylations and N-demethylations proceeding via hydroxylation; in plants and microbes, they catalyze a …
Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.
Nair JK, Attarwala H, Sehgal A, Wang Q, Aluri K, Zhang X, Gao M, Liu J, Indrakanti R, Schofield S, Kretschmer P, Brown CR, Gupta S, Willoughby JLS, Boshar JA, Jadhav V, Charisse K, Zimmermann T, Fitzgerald K, Manoharan M, Rajeev KG, Akinc A, Hutabarat R, Maier MA. Nair JK, et al. Nucleic Acids Res. 2017 Nov 2;45(19):10969-10977. doi: 10.1093/nar/gkx818. Nucleic Acids Res. 2017. PMID: 28981809 Free PMC article.
Covalent attachment of a synthetic triantennary N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein (ASGPR)-mediated targeted delivery of therapeutically active siRNAs to hepatocytes in vivo. ...
Covalent attachment of a synthetic triantennary N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asial …
Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ. Rydzik AM, et al. Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10925-7. doi: 10.1002/anie.201406125. Epub 2014 Aug 27. Angew Chem Int Ed Engl. 2014. PMID: 25164544 Free PMC article.
BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers....
BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products wi …
On the robustness of N-mixture models.
Link WA, Schofield MR, Barker RJ, Sauer JR. Link WA, et al. Ecology. 2018 Jul;99(7):1547-1551. doi: 10.1002/ecy.2362. Epub 2018 Jun 6. Ecology. 2018. PMID: 29702727
N-mixture models provide an appealing alternative to mark-recapture models, in that they allow for estimation of detection probability and population size from count data, without requiring that individual animals be identified. There is, however, a cost to using the N
N-mixture models provide an appealing alternative to mark-recapture models, in that they allow for estimation of detection probabilit
Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals.
John T, Pires E, Hester SS, Salah E, Hopkinson RJ, Schofield CJ. John T, et al. Commun Chem. 2023 Jan 13;6(1):12. doi: 10.1038/s42004-022-00801-5. Commun Chem. 2023. PMID: 36698022 Free PMC article.
While the roles of histone modification by this reaction require further investigation, we demonstrated the potential of N-terminal aminal formation to modulate protein function by conducting biochemical and cellular studies on the effects of HCHO on catalysis by 4-oxalocr …
While the roles of histone modification by this reaction require further investigation, we demonstrated the potential of N-terminal a …
Structural Basis of Metallo-beta-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates.
Farley AJM, Ermolovich Y, Calvopiña K, Rabe P, Panduwawala T, Brem J, Björkling F, Schofield CJ. Farley AJM, et al. ACS Infect Dis. 2021 Jun 11;7(6):1809-1817. doi: 10.1021/acsinfecdis.1c00104. Epub 2021 May 18. ACS Infect Dis. 2021. PMID: 34003651 Free PMC article.
We report on the synthesis and mechanism of inhibition of N-sulfamoylpyrrole-2-carboxylates (NSPCs) which are potent inhibitors of clinically relevant B1 subclass MBLs, including NDM-1. Crystallography reveals that the N-sulfamoyl NH(2) group displaces the dizinc br …
We report on the synthesis and mechanism of inhibition of N-sulfamoylpyrrole-2-carboxylates (NSPCs) which are potent inhibitors of cl …
Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in beta-lactam biosynthesis.
Rabe P, Kamps JJAG, Schofield CJ, Lohans CT. Rabe P, et al. Nat Prod Rep. 2018 Aug 15;35(8):735-756. doi: 10.1039/c8np00002f. Nat Prod Rep. 2018. PMID: 29808887 Free PMC article. Review.
Covering: up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucial roles in the biosynthesis of beta-lactam ring containing natural products. ...
Covering: up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucia …
Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha.
Corner TP, Teo RZR, Wu Y, Salah E, Nakashima Y, Fiorini G, Tumber A, Brasnett A, Holt-Martyn JP, Figg WD Jr, Zhang X, Brewitz L, Schofield CJ. Corner TP, et al. Chem Sci. 2023 Oct 27;14(43):12098-12120. doi: 10.1039/d3sc04253g. eCollection 2023 Nov 8. Chem Sci. 2023. PMID: 37969593 Free PMC article.
Crystallographic studies reveal that the N-hydroxythiazole derivatives compete with both 2OG and the substrate for binding to the FIH active site. Derivatisation of the N-hydroxythiazole scaffold has the potential to afford selective inhibitors for 2OG oxygenases ot …
Crystallographic studies reveal that the N-hydroxythiazole derivatives compete with both 2OG and the substrate for binding to the FIH …
Recent Progress in Histone Demethylase Inhibitors.
McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ. McAllister TE, et al. J Med Chem. 2016 Feb 25;59(4):1308-29. doi: 10.1021/acs.jmedchem.5b01758. Epub 2016 Feb 2. J Med Chem. 2016. PMID: 26710088 Review.
There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific dem …
There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of …
1,483 results