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Overview of novel multifunctional agents based on conjugates of γ-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease.
Makhaeva GF, Shevtsova EF, Boltneva NP, Lushchekina SV, Kovaleva NV, Rudakova EV, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: kovaleva nv. Chem Biol Interact. 2019 Aug 1;308:224-234. doi: 10.1016/j.cbi.2019.05.020. Epub 2019 May 14. Chem Biol Interact. 2019. PMID: 31100279 Review.
Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System.
Akimov MG, Kudryavtsev DS, Kryukova EV, Fomina-Ageeva EV, Zakharov SS, Gretskaya NM, Zinchenko GN, Serkov IV, Makhaeva GF, Boltneva NP, Kovaleva NV, Serebryakova OG, Lushchekina SV, Palikov VA, Palikova Y, Dyachenko IA, Kasheverov IE, Tsetlin VI, Bezuglov VV. Akimov MG, et al. Among authors: kovaleva nv. Biomolecules. 2020 Feb 12;10(2):283. doi: 10.3390/biom10020283. Biomolecules. 2020. PMID: 32059521 Free PMC article.
New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment.
Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Lushchekina SV, Faingold II, Poletaeva DA, Soldatova YV, Kotelnikova RA, Serkov IV, Ustinov AK, Proshin AN, Radchenko EV, Palyulin VA, Richardson RJ. Makhaeva GF, et al. Among authors: kovaleva nv. Molecules. 2020 Dec 12;25(24):5891. doi: 10.3390/molecules25245891. Molecules. 2020. PMID: 33322783 Free PMC article.
Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases.
Bachurin SO, Makhaeva GF, Shevtsova EF, Boltneva NP, Kovaleva NV, Lushchekina SV, Rudakova EV, Dubova LG, Vinogradova DV, Sokolov VB, Aksinenko AY, Fisenko VP, Richardson RJ, Aliev G. Bachurin SO, et al. Among authors: kovaleva nv. Sci Rep. 2019 Mar 19;9(1):4873. doi: 10.1038/s41598-019-41272-4. Sci Rep. 2019. PMID: 30890752 Free PMC article.
Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors.
Makhaeva GF, Elkina NA, Shchegolkov EV, Boltneva NP, Lushchekina SV, Serebryakova OG, Rudakova EV, Kovaleva NV, Radchenko EV, Palyulin VA, Burgart YV, Saloutin VI, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: kovaleva nv. Bioorg Chem. 2019 Oct;91:103097. doi: 10.1016/j.bioorg.2019.103097. Epub 2019 Jul 3. Bioorg Chem. 2019. PMID: 31323527
Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation.
Makhaeva GF, Kovaleva NV, Boltneva NP, Lushchekina SV, Rudakova EV, Stupina TS, Terentiev AA, Serkov IV, Proshin AN, Radchenko EV, Palyulin VA, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: kovaleva nv. Bioorg Chem. 2020 Jan;94:103387. doi: 10.1016/j.bioorg.2019.103387. Epub 2019 Oct 28. Bioorg Chem. 2020. PMID: 31735356
New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment.
Makhaeva GF, Kovaleva NV, Boltneva NP, Lushchekina SV, Astakhova TY, Rudakova EV, Proshin AN, Serkov IV, Radchenko EV, Palyulin VA, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: kovaleva nv. Molecules. 2020 Aug 27;25(17):3915. doi: 10.3390/molecules25173915. Molecules. 2020. PMID: 32867324 Free PMC article.
Corrigendum to "Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation". [Bioorg. Chem. 94C (2019)].
Makhaeva GF, Kovaleva NV, Boltneva NP, Lushchekina SV, Rudakova EV, Stupina TS, Terentiev AA, Serkov IV, Proshin AN, Radchenko EV, Palyulin VA, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: kovaleva nv. Bioorg Chem. 2020 Mar;96:103563. doi: 10.1016/j.bioorg.2019.103563. Epub 2020 Jan 31. Bioorg Chem. 2020. PMID: 32007720 No abstract available.
Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits.
Iomdina EN, Khoroshilova-Maslova IP, Robustova OV, Averina OA, Kovaleva NA, Aliev G, Reddy VP, Zamyatnin AA Jr, Skulachev MV, Senin II, Skulachev VP. Iomdina EN, et al. Among authors: kovaleva na. Front Biosci (Landmark Ed). 2015 Jan 1;20:892-901. doi: 10.2741/4343. Front Biosci (Landmark Ed). 2015. PMID: 25553485
Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.
Shchegol'kov EV, Makhaeva GF, Boltneva NP, Lushchekina SV, Serebryakova OG, Rudakova EV, Kovaleva NV, Burgart YV, Saloutin VI, Chupakhin ON, Bachurin SO, Richardson RJ. Shchegol'kov EV, et al. Among authors: kovaleva nv. Bioorg Med Chem. 2017 Aug 1;25(15):3997-4007. doi: 10.1016/j.bmc.2017.05.045. Epub 2017 May 20. Bioorg Med Chem. 2017. PMID: 28578994
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