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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1917 1
1952 4
1953 13
1954 15
1955 8
1956 4
1957 8
1958 7
1959 6
1960 2
1961 3
1962 10
1963 8
1964 19
1965 16
1966 25
1967 24
1968 27
1969 22
1970 12
1971 19
1972 13
1973 16
1974 14
1975 17
1976 8
1977 10
1978 9
1979 17
1980 16
1981 18
1982 16
1983 31
1984 33
1985 25
1986 28
1987 40
1988 53
1989 65
1990 76
1991 52
1992 57
1993 69
1994 84
1995 110
1996 141
1997 166
1998 157
1999 191
2000 199
2001 279
2002 349
2003 405
2004 430
2005 573
2006 646
2007 778
2008 1010
2009 998
2010 1246
2011 1435
2012 1614
2013 1825
2014 2226
2015 2370
2016 2458
2017 2735
2018 2902
2019 3310
2020 3860
2021 4219
2022 3901
2023 3826
2024 1161

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41,114 results

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Page 1
Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment.
Hwang ES, Song SB. Hwang ES, et al. Biomolecules. 2020 Apr 29;10(5):687. doi: 10.3390/biom10050687. Biomolecules. 2020. PMID: 32365524 Free PMC article. Review.
Our review assures safety in current usage level of NAM, but also finds potential risks for epigenetic alterations associated with chronic use of NAM at high doses. It also suggests directions of the future studies to ensure safer application of NAM....
Our review assures safety in current usage level of NAM, but also finds potential risks for epigenetic alterations associated with ch …
Nicotinamide Prevents UVB- and Oxidative Stress‒Induced Photoaging in Human Primary Keratinocytes.
Tan CYR, Tan CL, Chin T, Morenc M, Ho CY, Rovito HA, Quek LS, Soon AL, Lim JSY, Dreesen O, Oblong JE, Bellanger S. Tan CYR, et al. J Invest Dermatol. 2022 Jun;142(6):1670-1681.e12. doi: 10.1016/j.jid.2021.10.021. Epub 2021 Nov 3. J Invest Dermatol. 2022. PMID: 34740582 Free article.
Nicotinamide (NAM), a NAM adenine dinucleotide precursor, is known for its benefits to skin health. Under standard culture conditions, NAM delays the differentiation and enhances the proliferation of human primary keratinocytes, leading to the maintenance of …
Nicotinamide (NAM), a NAM adenine dinucleotide precursor, is known for its benefits to skin health. Under standard culture con …
Nicotinamide inhibits melanoma in vitro and in vivo.
Scatozza F, Moschella F, D'Arcangelo D, Rossi S, Tabolacci C, Giampietri C, Proietti E, Facchiano F, Facchiano A. Scatozza F, et al. J Exp Clin Cancer Res. 2020 Oct 7;39(1):211. doi: 10.1186/s13046-020-01719-3. J Exp Clin Cancer Res. 2020. PMID: 33028392 Free PMC article.
In the present study the anti-melanoma activity of Nicotinamide (NAM), the amide form of Niacin, was assessed in vitro and in vivo. ...NAM significantly delayed tumor growth in vivo (p 0.0005) and improved survival of melanoma-bearing mice (p 0.0001). ...
In the present study the anti-melanoma activity of Nicotinamide (NAM), the amide form of Niacin, was assessed in vitro and in vivo. . …
Nicotinamide and acute kidney injury.
Fontecha-Barriuso M, Lopez-Diaz AM, Carriazo S, Ortiz A, Sanz AB. Fontecha-Barriuso M, et al. Clin Kidney J. 2021 Sep 23;14(12):2453-2462. doi: 10.1093/ckj/sfab173. eCollection 2021 Dec. Clin Kidney J. 2021. PMID: 34950458 Free PMC article.
In a recent issue of ckj, Piedrafita et al. reported that urine tryptophan and kynurenine are reduced in cardiac bypass surgery patients that develop acute kidney injury (AKI), suggesting reduced activity of the kynurenine pathway of nicotinamide (NAM) adenine dinucleotide …
In a recent issue of ckj, Piedrafita et al. reported that urine tryptophan and kynurenine are reduced in cardiac bypass surgery patients tha …
Nevus-associated melanoma: facts and controversies.
Pampena R, Lai M, Piana S, Lallas A, Pellacani G, Longo C. Pampena R, et al. G Ital Dermatol Venereol. 2020 Feb;155(1):65-75. doi: 10.23736/S0392-0488.19.06534-9. G Ital Dermatol Venereol. 2020. PMID: 32100974 Review.
NAM has been regarded as a model to investigate melanoma origin. ...Regarding prognosis, NAM is generally thinner and more frequently in-situ than de-novo melanoma. ...
NAM has been regarded as a model to investigate melanoma origin. ...Regarding prognosis, NAM is generally thinner and more fre
Nail Apparatus Melanoma: Current Management and Future Perspectives.
Ito T, Hashimoto H, Kaku-Ito Y, Tanaka Y, Nakahara T. Ito T, et al. J Clin Med. 2023 Mar 12;12(6):2203. doi: 10.3390/jcm12062203. J Clin Med. 2023. PMID: 36983205 Free PMC article. Review.
Nail apparatus melanoma (NAM) is a rare type of cutaneous melanoma that belongs to the acral melanoma subtype. ...In this review, we focus on recent advances in the management of NAM. Localized NAM should be surgically removed; amputation of the digit and dig …
Nail apparatus melanoma (NAM) is a rare type of cutaneous melanoma that belongs to the acral melanoma subtype. ...In this review, we …
Possible mechanisms of cancer prevention by nicotinamide.
Buqué A, Bloy N, Kroemer G, Galluzzi L. Buqué A, et al. Br J Pharmacol. 2021 May;178(10):2034-2040. doi: 10.1111/bph.15096. Epub 2020 Jun 3. Br J Pharmacol. 2021. PMID: 32383227 Free article. Review.
Nicotinamide (NAM) is a precursor of vitamin B(3) commonly sold over the counter as a nutritional supplement with anti-aging properties. Accumulating preclinical evidence indicates that NAM also mediates oncopreventive effects against a variety of neoplasms. ...
Nicotinamide (NAM) is a precursor of vitamin B(3) commonly sold over the counter as a nutritional supplement with anti-aging properti …
A review of nevus-associated melanoma: What is the evidence?
Dessinioti C, Geller AC, Stratigos AJ. Dessinioti C, et al. J Eur Acad Dermatol Venereol. 2022 Nov;36(11):1927-1936. doi: 10.1111/jdv.18453. Epub 2022 Aug 16. J Eur Acad Dermatol Venereol. 2022. PMID: 35857388 Review.
Another matter of debate regarded the possibility that the reported differences in NAM vs. de novo melanoma were due to an underestimation of NAM in thicker lesions due to obliteration of the nevus component by the tumour. ...In this review, we present a comprehensi …
Another matter of debate regarded the possibility that the reported differences in NAM vs. de novo melanoma were due to an underestim …
Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages.
Curran CS, Dougherty EJ, Cui X, Li Y, Jeakle M, Gamble T, Demirkale CY, Torabi-Parizi P. Curran CS, et al. J Immunol. 2023 Jul 15;211(2):261-273. doi: 10.4049/jimmunol.2200552. J Immunol. 2023. PMID: 37314413 Free PMC article.
These NAM responses were associated with increased intracellular NAD levels formed through the salvage pathway. ...Continued study of NAM cell signals in vitro and in vivo may provide insight into infection-associated host pathologies and interventions....
These NAM responses were associated with increased intracellular NAD levels formed through the salvage pathway. ...Continued study of …
Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.
Hwang ES, Song SB. Hwang ES, et al. Cell Mol Life Sci. 2017 Sep;74(18):3347-3362. doi: 10.1007/s00018-017-2527-8. Epub 2017 Apr 17. Cell Mol Life Sci. 2017. PMID: 28417163 Review.
However, once administered to cells, NAM is rapidly converted to NAD(+) and, therefore, the cellular concentration of NAM decreases rapidly while that of NAD(+) increases. ...This possibility raises a concern on the validity of the interpretation of the results in t …
However, once administered to cells, NAM is rapidly converted to NAD(+) and, therefore, the cellular concentration of NAM decr …
41,114 results
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