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Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
J Med Chem. 1993 Sep 3;36(18):2689-700. doi: 10.1021/jm00070a013.
J Med Chem. 1993.
PMID: 8410981
A large number of camptothecin (CPT) analogs have been prepared in the 20S, 20RS, and 20R configurations with a number of ring A substituents. Topoisomerase I (T-I) inhibition data (IC50) have been obtained by standard procedures. ...Compounds in the 20RS configuration wer …
A large number of camptothecin (CPT) analogs have been prepared in the 20S, 20RS, and 20R configurations with a number of ring A subs …
Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin.
Wani MC, Nicholas AW, Wall ME.
Wani MC, et al.
J Med Chem. 1987 Dec;30(12):2317-9. doi: 10.1021/jm00395a024.
J Med Chem. 1987.
PMID: 3681902
The regenerated enantiomers 3a and 3b of 100% optical purity represent the key intermediates from which 20(R)-camptothecin (1a) and 20(S)-camptothecin (1b), respectively, have been prepared. The 20R analogue 1a was 10-100 times less active than the natural 20(S)-camptothec …
The regenerated enantiomers 3a and 3b of 100% optical purity represent the key intermediates from which 20(R)-camptothecin (1a) and 20(S)-ca …
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