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Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Wilkinson AJ, Ooi N, Finlayson J, Lee VE, Lyth D, Maskew KS, Newman R, Orr D, Ansell K, Birchall K, Canning P, Coombs P, Fusani L, McIver E, Pisco J, Ireland PM, Jenkins C, Norville IH, Southern SJ, Cowan R, Hall G, Kettleborough C, Savage VJ, Cooper IR. Wilkinson AJ, et al. Among authors: ooi n. Bioorg Med Chem Lett. 2023 Jun 15;90:129331. doi: 10.1016/j.bmcl.2023.129331. Epub 2023 May 13. Bioorg Med Chem Lett. 2023. PMID: 37187252 Free article.
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Lyons A, Kirkham J, Blades K, Orr D, Dauncey E, Smith O, Dick E, Walker R, Matthews T, Bunt A, Finlayson J, Morrison I, Savage VJ, Moyo E, Butler HS, Newman R, Ooi N, Smith A, Charrier C, Ratcliffe AJ, Stokes NR, Best S, Salisbury AM, Craighead M, Cooper IR. Lyons A, et al. Among authors: ooi n. Bioorg Med Chem Lett. 2022 Jun 1;65:128648. doi: 10.1016/j.bmcl.2022.128648. Epub 2022 Feb 26. Bioorg Med Chem Lett. 2022. PMID: 35231579
Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.
Charrier C, Salisbury AM, Savage VJ, Duffy T, Moyo E, Chaffer-Malam N, Ooi N, Newman R, Cheung J, Metzger R, McGarry D, Pichowicz M, Sigerson R, Cooper IR, Nelson G, Butler HS, Craighead M, Ratcliffe AJ, Best SA, Stokes NR. Charrier C, et al. Among authors: ooi n. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02100-16. doi: 10.1128/AAC.02100-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28223393 Free PMC article.
13 results