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2008 | 1 |
2014 | 1 |
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Insights into the biosynthesis and assembly of cryptophycean phycobiliproteins.
J Biol Chem. 2014 Sep 26;289(39):26691-26707. doi: 10.1074/jbc.M114.591131. Epub 2014 Aug 5.
J Biol Chem. 2014.
PMID: 25096577
Free PMC article.
Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.
Hamblin JN, Angell TD, Ballantine SP, Cook CM, Cooper AW, Dawson J, Delves CJ, Jones PS, Lindvall M, Lucas FS, Mitchell CJ, Neu MY, Ranshaw LE, Solanke YE, Somers DO, Wiseman JO.
Hamblin JN, et al.
Bioorg Med Chem Lett. 2008 Jul 15;18(14):4237-41. doi: 10.1016/j.bmcl.2008.05.052. Epub 2008 May 17.
Bioorg Med Chem Lett. 2008.
PMID: 18539455
Herein, we describe early SAR studies around this novel template highlighting preferred substituents and rationalization of SAR through X-ray crystal structures of analogues bound to the PDE4 active site. Pyrazolopyridine 20a was found to be a potent and selective PDE4 inh …
Herein, we describe early SAR studies around this novel template highlighting preferred substituents and rationalization of SAR through X-ra …
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