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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 2
1951 1
1963 1
1965 4
1967 3
1969 2
1970 1
1971 3
1972 1
1973 2
1974 1
1977 2
1978 5
1979 2
1980 1
1981 4
1982 1
1984 3
1985 3
1988 3
1989 3
1990 3
1991 8
1992 8
1993 4
1994 8
1995 7
1996 6
1997 11
1998 29
1999 32
2000 44
2001 50
2002 40
2003 50
2004 48
2005 51
2006 49
2007 55
2008 56
2009 52
2010 70
2011 62
2012 66
2013 75
2014 53
2015 70
2016 70
2017 55
2018 70
2019 92
2020 60
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1,287 results
Results by year
Filters applied: . Clear all The following term was not found in PubMed: Nurnaeimah
Page 1
NIK as a Druggable Mediator of Tissue Injury.
Valiño-Rivas L, Vaquero JJ, Sucunza D, Gutierrez S, Sanz AB, Fresno M, Ortiz A, Sanchez-Niño MD. Valiño-Rivas L, et al. Trends Mol Med. 2019 Apr;25(4):341-360. doi: 10.1016/j.molmed.2019.02.005. Epub 2019 Mar 26. Trends Mol Med. 2019. PMID: 30926358 Review.
The spectrum of NIK-associated disease now ranges from immunodeficiency (when NIK is defective) to autoimmunity, cancer, sterile inflammation, fibrosis, and metabolic disease when NIK is overactive. The development of novel small-molecule NIK inhibitor …
The spectrum of NIK-associated disease now ranges from immunodeficiency (when NIK is defective) to autoimmunity, cancer, steri …
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis.
Jie Z, Yang JY, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, Cheng X, Sun SC. Jie Z, et al. Nat Immunol. 2018 Nov;19(11):1224-1235. doi: 10.1038/s41590-018-0206-z. Epub 2018 Sep 24. Nat Immunol. 2018. PMID: 30250187 Free PMC article.
We identified the noncanonical NF-κB-inducing kinase (NIK) as a crucial mediator of mucosal DC function. DC-specific NIK deletion impaired intestinal immunoglobulin A (IgA) secretion and microbiota homeostasis, rendering mice sensitive to an intestinal pathogen, Cit …
We identified the noncanonical NF-κB-inducing kinase (NIK) as a crucial mediator of mucosal DC function. DC-specific NIK delet …
NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion.
Jung JU, Ravi S, Lee DW, McFadden K, Kamradt ML, Toussaint LG, Sitcheran R. Jung JU, et al. Curr Biol. 2016 Dec 19;26(24):3288-3302. doi: 10.1016/j.cub.2016.10.009. Epub 2016 Nov 23. Curr Biol. 2016. PMID: 27889261 Free PMC article.
Consistent with a role for NIK in regulating mitochondrial dynamics, we demonstrate that Drp1 is required for NIK-dependent, cytokine-induced invasion. ...Our results establish a new paradigm for IKK-independent NIK signaling and significantly expand the curr …
Consistent with a role for NIK in regulating mitochondrial dynamics, we demonstrate that Drp1 is required for NIK-dependent, c …
A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling.
Parvatiyar K, Pindado J, Dev A, Aliyari SR, Zaver SA, Gerami H, Chapon M, Ghaffari AA, Dhingra A, Cheng G. Parvatiyar K, et al. Nat Commun. 2018 Jul 17;9(1):2770. doi: 10.1038/s41467-018-05168-7. Nat Commun. 2018. PMID: 30018345 Free PMC article.
Cells lacking NIK display defective IFN activation in the DNA pathway due to impaired STING signaling, and NIK-deficient mice are more susceptible to DNA virus infection. ...Thus a previously undescribed pathway for NIK exists in activating IFN in the DNA pat …
Cells lacking NIK display defective IFN activation in the DNA pathway due to impaired STING signaling, and NIK-deficient mice …
NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.
Lacher SM, Thurm C, Distler U, Mohebiany AN, Israel N, Kitic M, Ebering A, Tang Y, Klein M, Wabnitz GH, Wanke F, Samstag Y, Bopp T, Kurschus FC, Simeoni L, Tenzer S, Waisman A. Lacher SM, et al. J Autoimmun. 2018 Nov;94:110-121. doi: 10.1016/j.jaut.2018.07.017. Epub 2018 Jul 29. J Autoimmun. 2018. PMID: 30061013
We elucidated the specific role of NIK in T cells using T-cell specific NIK-deficient (NIK(ΔT)) mice. Despite showing normal development of lymphoid organs, NIK(ΔT) mice were resistant to induction of CNS autoimmunity. ...Hence, our data disclose a hit …
We elucidated the specific role of NIK in T cells using T-cell specific NIK-deficient (NIK(ΔT)) mice. Despite showing n …
Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice.
Shen H, Ji Y, Xiong Y, Kim H, Zhong X, Jin MG, Shah YM, Omary MB, Liu Y, Qi L, Rui L. Shen H, et al. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19090-19097. doi: 10.1073/pnas.1901056116. Epub 2019 Sep 3. Proc Natl Acad Sci U S A. 2019. PMID: 31481626 Free PMC article.
Here, we identified NF-κB-inducing kinase (NIK) and IkB kinase α (IKKα) in thymic epithelial cells (TECs) as essential regulators of T cell development. ...These results unravel a hitherto unrecognized essential role of TEC-intrinsic NIK and IKKα pathways in autoimm …
Here, we identified NF-κB-inducing kinase (NIK) and IkB kinase α (IKKα) in thymic epithelial cells (TECs) as essential regulators of …
Non-canonical NF-κB signaling pathway.
Sun SC. Sun SC. Cell Res. 2011 Jan;21(1):71-85. doi: 10.1038/cr.2010.177. Epub 2010 Dec 21. Cell Res. 2011. PMID: 21173796 Free PMC article. Review.
A unique mechanism of NIK regulation is through its fate control: the basal level of NIK is kept low by a TRAF-cIAP destruction complex and signal-induced non-canonical NF-κB signaling involves NIK stabilization. Tight control of the fate of NIK is imp …
A unique mechanism of NIK regulation is through its fate control: the basal level of NIK is kept low by a TRAF-cIAP destructio …
Noncanonical NF-κB Signaling in Health and Disease.
Cildir G, Low KC, Tergaonkar V. Cildir G, et al. Trends Mol Med. 2016 May;22(5):414-429. doi: 10.1016/j.molmed.2016.03.002. Epub 2016 Apr 7. Trends Mol Med. 2016. PMID: 27068135 Review.
NIK-IKK complex interaction controls NF-κB-dependent inflammatory activation of endothelium in response to LTβR ligation.
Kucharzewska P, Maracle CX, Jeucken KCM, van Hamburg JP, Israelsson E, Furber M, Tas SW, Olsson HK. Kucharzewska P, et al. J Cell Sci. 2019 Apr 3;132(7):jcs225615. doi: 10.1242/jcs.225615. J Cell Sci. 2019. PMID: 30837284 Free article.
Endothelial inflammatory activation induced by synovial fluid from rheumatoid arthritis patients was significantly reduced by NIK knockdown, suggesting that NIK-mediated alternative activation of canonical NF-κB signaling is a key driver of pathological inflammatory …
Endothelial inflammatory activation induced by synovial fluid from rheumatoid arthritis patients was significantly reduced by NIK kno …
Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer.
Das R, Coupar J, Clavijo PE, Saleh A, Cheng TF, Yang X, Chen J, Van Waes C, Chen Z. Das R, et al. Mol Carcinog. 2019 Mar;58(3):411-425. doi: 10.1002/mc.22938. Epub 2018 Nov 28. Mol Carcinog. 2019. PMID: 30488488 Free PMC article.
Similarly, subsets of HNSCC lines displayed overexpression of LTβR, NIK, and RELB proteins. Recombinant LTβ, and siRNA depletion of endogenous LTβR and NIK, modulated expression of LTβR, NIK, and nuclear translocation of NF-κB2(p52)/RELB as well as functional …
Similarly, subsets of HNSCC lines displayed overexpression of LTβR, NIK, and RELB proteins. Recombinant LTβ, and siRNA depletion of e …
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