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The following term was not found in PubMed: Ranjijafaroudi
Page 1
Selective and Potent Molecular Glue Degraders for NIMA-Related Kinase 7.
Chen L, Huang L, Wen W, Zeng P, Wu Y, Han Q, Chen X, Guo Z, Yu H, Lu W, Jiang B. Chen L, et al. Angew Chem Int Ed Engl. 2025 Mar 17;64(12):e202500169. doi: 10.1002/anie.202500169. Epub 2025 Feb 21. Angew Chem Int Ed Engl. 2025. PMID: 39927695
Here, we developed a novel glutarimide analog with a tetrahydroimidazo[1,2-a]pyrazine scaffold that exhibited strong NIMA-related kinase 7 (NEK7) degradation potential. Further optimization led to the identification of LC-04-045 as a leading NEK7 MGD candidate, demonstrati …
Here, we developed a novel glutarimide analog with a tetrahydroimidazo[1,2-a]pyrazine scaffold that exhibited strong NIMA-related kin …
Role of NIMA-related kinase 2 in lung cancer: Mechanisms and therapeutic prospects.
Shah D, Joshi M, Patel BM. Shah D, et al. Fundam Clin Pharmacol. 2022 Oct;36(5):766-776. doi: 10.1111/fcp.12777. Epub 2022 Apr 2. Fundam Clin Pharmacol. 2022. PMID: 35338518 Review.
Radiation therapy and surgery also produce recurrence in lung cancer patients; this shows the need to develop novel agents acting on new targets. A never in mitosis (NIMA)-related kinase 2 (NEK2) is a serine/threonine kinase associated with the family of NIMA-relate …
Radiation therapy and surgery also produce recurrence in lung cancer patients; this shows the need to develop novel agents acting on new tar …
NEK8, a NIMA-family protein kinase at the core of the ciliary INV complex.
Roig J. Roig J. Cell Commun Signal. 2025 Apr 7;23(1):170. doi: 10.1186/s12964-025-02143-w. Cell Commun Signal. 2025. PMID: 40189576 Free PMC article. Review.
We also review the literature about the pathological consequences of different NEK8 variants in patients of nephronophthisis, renal-hepatic-pancreatic dysplasia and autosomal dominant polycystic kidney disease, three different types of ciliopathies. NEK8 belongs to the NIMA …
We also review the literature about the pathological consequences of different NEK8 variants in patients of nephronophthisis, renal-hepatic- …
NEK-mediated barrier regulation.
Barabutis N. Barabutis N. Pulm Pharmacol Ther. 2024 Sep;86:102313. doi: 10.1016/j.pupt.2024.102313. Epub 2024 Jun 21. Pulm Pharmacol Ther. 2024. PMID: 38909830
The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.
Lu KP, Hunter T. Lu KP, et al. Prog Cell Cycle Res. 1995;1:187-205. doi: 10.1007/978-1-4615-1809-9_15. Prog Cell Cycle Res. 1995. PMID: 9552363 Review.
However, in Aspergillus nidulans, activation of CDC2 itself is not sufficient to trigger mitosis if another mitotic protein kinase, NIMA, is not activated. Superficially, NIMA and CDC2 have analogous functions and are regulated in a similar manner. NIMA activ …
However, in Aspergillus nidulans, activation of CDC2 itself is not sufficient to trigger mitosis if another mitotic protein kinase, NIMA …
Nima- and Aurora-related kinases of malaria parasites.
Carvalho TG, Doerig C, Reininger L. Carvalho TG, et al. Biochim Biophys Acta. 2013 Jul;1834(7):1336-45. doi: 10.1016/j.bbapap.2013.02.022. Epub 2013 Feb 24. Biochim Biophys Acta. 2013. PMID: 23462523 Review.
Progression of the eukaryotic cell cycle is controlled by members of mitotic kinase of the families CDK (cyclin-dependent kinases), Aurora, Polo and NIMA. Plasmodium parasites possess cyclin-dependent protein kinases and cyclins, which strongly suggests that some of the pr …
Progression of the eukaryotic cell cycle is controlled by members of mitotic kinase of the families CDK (cyclin-dependent kinases), Aurora, …
Role of NEK2 in tumorigenesis and tumor progression.
Xia J, Zhao H, Edmondson JL, Koss B, Zhan F. Xia J, et al. Trends Mol Med. 2025 Jan;31(1):79-93. doi: 10.1016/j.molmed.2024.07.013. Epub 2024 Aug 24. Trends Mol Med. 2025. PMID: 39181803 Free PMC article. Review.
Never in mitosis A (NIMA)-related kinase 2 (NEK2) is a serine/threonine kinase found in the nucleus and cytoplasm throughout the cell cycle. ...
Never in mitosis A (NIMA)-related kinase 2 (NEK2) is a serine/threonine kinase found in the nucleus and cytoplasm throughout the cell …
3,636 results