Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1.
Chen R, Hao X, Chen J, Zhang C, Fan H, Lian F, Chen X, Wang C, Xia Y.
Chen R, et al.
J Transl Med. 2023 Aug 16;21(1):549. doi: 10.1186/s12967-023-04400-3.
J Transl Med. 2023.
PMID: 37587470
Free PMC article.
RESULTS: JorA inhibited the proliferation of MIBC cells, and the IC(50) of T24 and UM-UC-3 was 0.054 and 0.084 muM, respectively. ...Specifically, JorA dampened the DNA synthesis rate, induced phosphatidylserine eversion, and inhibited cell migration. ...
RESULTS: JorA inhibited the proliferation of MIBC cells, and the IC(50) of T24 and UM-UC-3 was 0.054 and 0.084 muM, respectively. ... …