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What's new on CDC25 phosphatase inhibitors.
Contour-Galcera MO, Sidhu A, Prévost G, Bigg D, Ducommun B. Contour-Galcera MO, et al. Pharmacol Ther. 2007 Jul;115(1):1-12. doi: 10.1016/j.pharmthera.2007.03.009. Epub 2007 Apr 21. Pharmacol Ther. 2007. PMID: 17531323 Review.
But some inhibitors can combine in the same molecule several of these mechanisms, thus by fitting into the active site of the enzyme through one part of the molecule and bringing the reactive moiety in close proximity to the catalytic cysteine. This review summarizes novel …
But some inhibitors can combine in the same molecule several of these mechanisms, thus by fitting into the active site of the enzyme through …
Automatic extraction of the mitral valve chordae geometry for biomechanical simulation.
Panicheva D, Villard PF, Hammer PE, Perrin D, Berger MO. Panicheva D, et al. Int J Comput Assist Radiol Surg. 2021 May;16(5):709-720. doi: 10.1007/s11548-021-02368-3. Epub 2021 May 12. Int J Comput Assist Radiol Surg. 2021. PMID: 33978895
The method has also been tested within a structural simulation of the mitral valve closed state. CONCLUSION: Our results show that the chordae architecture resulting from our algorithm can give results similar to experienced users while providing an equivalent biomechanica …
The method has also been tested within a structural simulation of the mitral valve closed state. CONCLUSION: Our results show that th …
Chronic food restriction in mice and increased systemic ghrelin induce preference for running wheel activity.
Tezenas du Montcel C, Cao J, Mattioni J, Hamelin H, Lebrun N, Ramoz N, Gorwood P, Tolle V, Viltart O. Tezenas du Montcel C, et al. Psychoneuroendocrinology. 2023 Sep;155:106311. doi: 10.1016/j.psyneuen.2023.106311. Epub 2023 Jun 7. Psychoneuroendocrinology. 2023. PMID: 37295225 Free article.
CONCLUSIONS: These data provide evidence that food restriction-induced physical activity is closely correlated with metabolic adaptations to nutritional status implicating ghrelin in the quantity of physical activity....
CONCLUSIONS: These data provide evidence that food restriction-induced physical activity is closely correlated with metabolic adaptat …
Functional analysis of monoclonal antibodies against the Plasmodium falciparum PfEMP1-VarO adhesin.
Guillotte M, Nato F, Juillerat A, Hessel A, Marchand F, Lewit-Bentley A, Bentley GA, Vigan-Womas I, Mercereau-Puijalon O. Guillotte M, et al. Malar J. 2016 Jan 15;15:28. doi: 10.1186/s12936-015-1016-5. Malar J. 2016. PMID: 26772184 Free PMC article.
Based on competition ELISA and binding to mutant DBL1 domains, two distinct binding sites for rosette-disrupting mAbs were identified in close proximity to the RBC-binding site. CONCLUSIONS: Rosette-inhibitory antibodies bind to conformation-dependent epitopes located c …
Based on competition ELISA and binding to mutant DBL1 domains, two distinct binding sites for rosette-disrupting mAbs were identified in …
A folding switch regulates interleukin 27 biogenesis and secretion of its α-subunit as a cytokine.
Müller SI, Friedl A, Aschenbrenner I, Esser-von Bieren J, Zacharias M, Devergne O, Feige MJ. Müller SI, et al. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1585-1590. doi: 10.1073/pnas.1816698116. Epub 2019 Jan 16. Proc Natl Acad Sci U S A. 2019. PMID: 30651310 Free PMC article.
This provides the basis for a more human-like IL-27 system in mice and establishes a secretion-competent human IL-27alpha that signals on its own and can regulate immune cell function. Taken together, our data reveal a close link between protein folding and immunoregulatio …
This provides the basis for a more human-like IL-27 system in mice and establishes a secretion-competent human IL-27alpha that signals on it …
Safe disconnection of 5-fluorouracil elastomeric pumps: The benefit of a closed-system-transfer device designed for cytotoxic drug administration/perfusion.
Raphaëlle P, Elodie P, Nathalie J, Odile A, Paul S, Isabelle M, Hélène L. Raphaëlle P, et al. J Vasc Access. 2021 Sep 18:11297298211044017. doi: 10.1177/11297298211044017. Online ahead of print. J Vasc Access. 2021. PMID: 34538108
This study was designed to evaluate the risk of 5-fluorouracil (5-FU) contamination for nurses when disconnecting the infusion line of an elastomeric pump from a non-coring needle, by comparing three configurations: the first one using standard Male and Female Luer lock (Group 1) …
This study was designed to evaluate the risk of 5-fluorouracil (5-FU) contamination for nurses when disconnecting the infusion line of an el …
Rhizobium alamii sp. nov., an exopolysaccharide-producing species isolated from legume and non-legume rhizospheres.
Berge O, Lodhi A, Brandelet G, Santaella C, Roncato MA, Christen R, Heulin T, Achouak W. Berge O, et al. Int J Syst Evol Microbiol. 2009 Feb;59(Pt 2):367-72. doi: 10.1099/ijs.0.000521-0. Int J Syst Evol Microbiol. 2009. PMID: 19196780
The genetic diversity revealed by REP-PCR fingerprinting indicated that the isolates correspond to different strains. 16S rRNA gene sequence analysis showed that the isolates are closely related to the strains Rhizobium sp. YAS34 and USDA 1920, respectively isolated from s …
The genetic diversity revealed by REP-PCR fingerprinting indicated that the isolates correspond to different strains. 16S rRNA gene sequence …
Reptin and Pontin oligomerization and activity are modulated through histone H3 N-terminal tail interaction.
Queval R, Papin C, Dalvai M, Bystricky K, Humbert O. Queval R, et al. J Biol Chem. 2014 Dec 5;289(49):33999-4012. doi: 10.1074/jbc.M114.576785. Epub 2014 Oct 21. J Biol Chem. 2014. PMID: 25336637 Free PMC article.
We propose that changes in the oligomeric status of Reptin/Pontin create a platform that brings specific cofactors close to gene promoters and loads regulatory factors to establish an active state of chromatin....
We propose that changes in the oligomeric status of Reptin/Pontin create a platform that brings specific cofactors close to gene prom …
[Psychotic women and motherhood: what risks for the child?].
Cazas O. Cazas O. Gynecol Obstet Fertil. 2007 Oct;35(10):1055-9. doi: 10.1016/j.gyobfe.2007.07.031. Epub 2007 Sep 21. Gynecol Obstet Fertil. 2007. PMID: 17889586 French.
Nevertheless, it is a topical question as neuroleptic drugs efficiency as well as mental health policy encourage them to live as close to normality as possible. Therefore, they have sexual relations, they have children. Since 1975, children born from psychotic mothers have …
Nevertheless, it is a topical question as neuroleptic drugs efficiency as well as mental health policy encourage them to live as close …
Integrated DNA and fingerprint analyses in the identification of 60-year-old mummified human remains discovered in an Alaskan glacier.
Loreille OM, Parr RL, McGregor KA, Fitzpatrick CM, Lyon C, Yang DY, Speller CF, Grimm MR, Grimm MJ, Irwin JA, Robinson EM. Loreille OM, et al. J Forensic Sci. 2010 May;55(3):813-8. doi: 10.1111/j.1556-4029.2010.01356.x. Epub 2010 Apr 2. J Forensic Sci. 2010. PMID: 20384910
This report describes the identification of a merchant mariner who perished in 1948 when Northwest Airlines Flight 4422, a DC-4 carrying 24 seamen and six crew members crashed into Mount Sanford, Alaska. Fifty-one years later, a human forearm and hand were found close by t …
This report describes the identification of a merchant mariner who perished in 1948 when Northwest Airlines Flight 4422, a DC-4 carrying 24 …
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