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Page 1
Clinical Experience of Proteasome Inhibitor Bortezomib Regarding Efficacy and Safety in Severe Systemic Lupus Erythematosus: A Nationwide Study.
Walhelm T, Gunnarsson I, Heijke R, Leonard D, Trysberg E, Eriksson P, Sjöwall C. Walhelm T, et al. Front Immunol. 2021 Oct 1;12:756941. doi: 10.3389/fimmu.2021.756941. eCollection 2021. Front Immunol. 2021. PMID: 34659263 Free PMC article.
Reduction of global disease activity was recorded by decreasing SLEDAI-2K scores over time and remained significantly reduced at the 6-month (p=0.007) and the 12-month (p=0.008) follow-up visits. From BTZ initiation, complement protein 3 (C3) levels increased …
Reduction of global disease activity was recorded by decreasing SLEDAI-2K scores over time and remained significantly reduced at the 6-month …
Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice.
Siddiqui RA, Hassan S, Harvey KA, Rasool T, Das T, Mukerji P, DeMichele S. Siddiqui RA, et al. Br J Nutr. 2009 Oct;102(7):967-75. doi: 10.1017/S0007114509345250. Epub 2009 Apr 27. Br J Nutr. 2009. PMID: 19393114

Curcumin c3 at 2.5 microg/ml also inhibited chymotrypsin-like 20S proteasome activity in these cells by 25 % (P < 0.05). ...Additionally, the effect of curcumin c3 on preventing and/or reversing cachexia was also evident by gains in the weight of th

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Curcumin c3 at 2.5 microg/ml also inhibited chymotrypsin-like 20S proteasome activity in these cells by 25 % (P < 0.

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Acylated protopanaxadiol-type ginsenosides from the root of Panax ginseng.
Zhu GY, Li YW, Hau DK, Jiang ZH, Yu ZL, Fong WF. Zhu GY, et al. Chem Biodivers. 2011 Oct;8(10):1853-63. doi: 10.1002/cbdv.201000196. Chem Biodivers. 2011. PMID: 22006713
The structures of the new compounds were determined by spectroscopic methods, including 1D- and 2D-NMR, HR-MS, and chemical transformation as (20S)- 3-O-{beta-D-6-O-[(E)-but-2-enoyl]glucopyranosyl-(12)-beta-D-glucopyranosyl}-20-O-[beta-D-xylopyranosyl-(14)-alpha-L-arabinop …
The structures of the new compounds were determined by spectroscopic methods, including 1D- and 2D-NMR, HR-MS, and chemical transformation a …
Two New Ergosterol Derivatives from the Basidiomycete Cortinarius glaucopus.
Aung HT, Porta A, Clericuzio M, Takaya Y, Vidari G. Aung HT, et al. Chem Biodivers. 2017 May;14(5). doi: 10.1002/cbdv.201600421. Epub 2017 Apr 13. Chem Biodivers. 2017. PMID: 27982523
Calculations were performed by means of DFT with the B3LYP functional at 6-31 + G(d,p) level of theory, in CHCl(3) as the solvent. The structures of the new ergosterol derivatives, called glaucoposterol A (1) and B (2), were thus established as (3S,5R,7R,10R,13R,17R,20S …
Calculations were performed by means of DFT with the B3LYP functional at 6-31 + G(d,p) level of theory, in CHCl(3) as the solvent. Th …
Changes in skeletal muscle proteolytic gene expression after prophylactic supplementation of EGCG and NAC and eccentric damage.
Kerksick CM, Roberts MD, Dalbo VJ, Kreider RB, Willoughby DS. Kerksick CM, et al. Food Chem Toxicol. 2013 Nov;61:47-52. doi: 10.1016/j.fct.2013.01.026. Epub 2013 Jan 31. Food Chem Toxicol. 2013. PMID: 23376779
The expression of proteolytic genes [i.e., muscle ring-finger 1 (MuRF1), atrogin-1, alpha-type 20S subunit C2 (HC2), alpha-type 20S subunit C3 (HC3), ubiquitin protein ligase 3B (UBE3B), mu-calpain, and m-calpain] was quantified using real-time RT-PCR. ...Inc …
The expression of proteolytic genes [i.e., muscle ring-finger 1 (MuRF1), atrogin-1, alpha-type 20S subunit C2 (HC2), alpha-type 20 …
(20S)-Protopanaxadiol Ginsenosides Induced Cytotoxicity via Blockade of Autophagic Flux in HGC-27 Cells.
Han Q, Han L, Tie F, Wang Z, Ma C, Li J, Wang H, Li G. Han Q, et al. Chem Biodivers. 2020 Jul;17(7):e2000187. doi: 10.1002/cbdv.202000187. Epub 2020 Jun 29. Chem Biodivers. 2020. PMID: 32384197
(20S)-Protopanaxadiol ginsenosides Rg3, Rh2 and PPD have been demonstrated for their anticancer activity. ...
(20S)-Protopanaxadiol ginsenosides Rg3, Rh2 and PPD have been demonstrated for their anticancer activity. ...
Activation and inhibition of the proteasome by betulinic acid and its derivatives.
Huang L, Ho P, Chen CH. Huang L, et al. FEBS Lett. 2007 Oct 16;581(25):4955-9. doi: 10.1016/j.febslet.2007.09.031. Epub 2007 Sep 24. FEBS Lett. 2007. PMID: 17904555 Free PMC article.
Chemical modifications at the C-3 position of BA resulted in compounds, such as dimethylsuccinyl BA (DSB), with various inhibitory activities against the human 20S proteasome. Interestingly, the proteasomal activation by BA and the inhibitory activity of DSB could be abrog …
Chemical modifications at the C-3 position of BA resulted in compounds, such as dimethylsuccinyl BA (DSB), with various inhibitory activitie …
Detection rates and sites of unruptured intracranial aneurysms according to sex and age: an analysis of MR angiography-based brain examinations of 4070 healthy Japanese adults.
Imaizumi Y, Mizutani T, Shimizu K, Sato Y, Taguchi J. Imaizumi Y, et al. J Neurosurg. 2018 Apr 6;130(2):573-578. doi: 10.3171/2017.9.JNS171191. J Neurosurg. 2018. PMID: 29624149
Within the ICA, C1 was the site of 46 aneurysms (24.5%); C2, 57 (30.3%); and C3, 29 (15.4%). The aneurysm detection rates for C2, C3, and C4 were 2.23%, 1.23%, and 0.64%, respectively, for women and 0.68%, 0.34%, and 0.21%, respectively, for men; ICA aneurysms were …
Within the ICA, C1 was the site of 46 aneurysms (24.5%); C2, 57 (30.3%); and C3, 29 (15.4%). The aneurysm detection rates for C2, …
Production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new UDP-glycosyltransferase from Bacillus subtilis.
Liang H, Hu Z, Zhang T, Gong T, Chen J, Zhu P, Li Y, Yang J. Liang H, et al. Metab Eng. 2017 Nov;44:60-69. doi: 10.1016/j.ymben.2017.07.008. Epub 2017 Aug 2. Metab Eng. 2017. PMID: 28778764 Free article.
Ginsenosides are the main bioactive constituents of Panax species, which are biosynthesized by glycosylation at C3-OH and/or C20-OH of protopanaxadiol (PPD), C6-OH and/or C20-OH of protopanaxatriol (PPT). ...In our study, a new UDP-glycosyltransferase UGT109A1 was identifi …
Ginsenosides are the main bioactive constituents of Panax species, which are biosynthesized by glycosylation at C3-OH and/or C20-OH o …
Reduction of digoxin to 20R-dihydrodigoxin by cultures of Eubacterium lentum.
Robertson LW, Chandrasekaran A, Reuning RH, Hui J, Rawal BD. Robertson LW, et al. Appl Environ Microbiol. 1986 Jun;51(6):1300-3. doi: 10.1128/aem.51.6.1300-1303.1986. Appl Environ Microbiol. 1986. PMID: 3729400 Free PMC article.
Reduction of the cardiac glycoside by growing cultures of E. lentum ATCC 25559 proceeded in a stereospecific manner, with the 20R-dihydrodigoxin constituting more than 99% of the product formed. This is in contrast to the 3:1 ratio of 20R and 20S epimers formed in the chem …
Reduction of the cardiac glycoside by growing cultures of E. lentum ATCC 25559 proceeded in a stereospecific manner, with the 20R-dihydrodig …
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