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11 results
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Page 1
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Ridker PM, et al. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17. N Engl J Med. 2017. PMID: 28304242 Free article. Clinical Trial.
RESULTS: At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P<0.001) and a median reduction …
RESULTS: At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab …
Acute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection.
Martin-Loeches I, Papiol E, Rodríguez A, Diaz E, Zaragoza R, Granada RM, Socias L, Bonastre J, Valverdú M, Pozo JC, Luque P, Juliá-Narvaéz JA, Cordero L, Albaya A, Serón D, Rello J; H1N1 SEMICYUC Working Group. Martin-Loeches I, et al. Crit Care. 2011 Feb 22;15(1):R66. doi: 10.1186/cc10046. Crit Care. 2011. PMID: 21342489 Free PMC article.

Patients with AKI had a higher Acute Physiology and Chronic Health Evaluation II score (19.2 8.3 versus 12.6 5.9; P < 0.001), a higher Sequential Organ Failure Assessment score (8.7 4.2 versus 4.8 2.9; P < 0.001), more need for mechanical ventilation (MV) (87.

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Patients with AKI had a higher Acute Physiology and Chronic Health Evaluation II score (19.2 8.3 versus 12.6 5.9; P < 0.001), a hi

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The cultural and chronological context of early Holocene maize and squash domestication in the Central Balsas River Valley, Mexico.
Ranere AJ, Piperno DR, Holst I, Dickau R, Iriarte J. Ranere AJ, et al. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5014-8. doi: 10.1073/pnas.0812590106. Epub 2009 Mar 23. Proc Natl Acad Sci U S A. 2009. PMID: 19307573 Free PMC article.
We report here on archaeological investigations in a region of the Central Balsas located near the Iguala Valley in Guerrero state that show for the first time a long sequence of human occupation and plant exploitation reaching back to the early Holocene. One of the sites …
We report here on archaeological investigations in a region of the Central Balsas located near the Iguala Valley in Guerrero state th …
Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study.
Moreno G, Rodríguez A, Reyes LF, Gomez J, Sole-Violan J, Díaz E, Bodí M, Trefler S, Guardiola J, Yébenes JC, Soriano A, Garnacho-Montero J, Socias L, Del Valle Ortíz M, Correig E, Marín-Corral J, Vallverdú-Vidal M, Restrepo MI, Torres A, Martín-Loeches I; GETGAG Study Group. Moreno G, et al. Intensive Care Med. 2018 Sep;44(9):1470-1482. doi: 10.1007/s00134-018-5332-4. Epub 2018 Aug 3. Intensive Care Med. 2018. PMID: 30074052 Free PMC article.

Crude ICU mortality was higher in patients who received corticosteroids (27.5%) than in patients who did not receive corticosteroids (18.8%, p < 0.001). After PS matching, corticosteroid use was associated with ICU mortality in the Cox (HR = 1.32 [95% CI 1.08-1.60],

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Crude ICU mortality was higher in patients who received corticosteroids (27.5%) than in patients who did not receive corticosteroids (18.8%, …
Influence of the food to microorganisms (F/M) ratio and temperature on batch anaerobic digestion processes with and without zeolite addition.
Montalvo S, Gonzalez P, Mena C, Guerrero L, Borja R. Montalvo S, et al. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(12):1785-94. doi: 10.1080/10934529.2012.689235. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012. PMID: 22755525
Three laboratory-scale experimental runs were conducted using a synthetic substrate with a COD:N:P ratio of 500:5:1. The first run (I) was conducted at a constant temperature of 27C, increasing the F/M ratio from 0.21 to 0.40 (g COD/g VSS). ...
Three laboratory-scale experimental runs were conducted using a synthetic substrate with a COD:N:P ratio of 500:5:1. The first run (I …
Tamoxifen-loaded folate-conjugate poly[(p-nitrophenyl acrylate)-co-(N-isopropylacrylamide)] sub-microgel as antitumoral drug delivery system.
Blanco MD, Guerrero S, Benito M, Teijón C, Olmo R, Muñíz E, Katime I, Teijón JM. Blanco MD, et al. J Biomed Mater Res A. 2010 Dec 15;95(4):1028-40. doi: 10.1002/jbm.a.32929. Epub 2010 Sep 24. J Biomed Mater Res A. 2010. PMID: 20872870
Folate-conjugate poly[(p-nitrophenyl acrylate)-co-(N-isopropylacrylamide)] sub-microgel (F-SubMG) was loaded with tamoxifen (TMX) to obtain low (9.0 0.4 mug TMX/mg F-SubMG) and high (112.0 15.0 mug TMX/mg F-SubMG) load TMX-loaded F-SubMGs. ...
Folate-conjugate poly[(p-nitrophenyl acrylate)-co-(N-isopropylacrylamide)] sub-microgel (F-SubMG) was loaded with tamoxifen (TMX) to …
Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling.
del Monte F, Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK, Hajjar RJ. del Monte F, et al. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5622-7. doi: 10.1073/pnas.0305778101. Epub 2004 Mar 25. Proc Natl Acad Sci U S A. 2004. PMID: 15044708 Free PMC article.

During the first hour after I/R, the rate of nonsustained VT plus VF was 16 +/- 5 episodes per h (n = 6) in the Ad.beta gal group, 22 +/- 6 in the Ad.PV group, and 4 +/- 2(n = 6, P < 0.01) in the Ad.SERCA2a group. The decrease in VT plus VF in the Ad.SERCA2a group was c

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During the first hour after I/R, the rate of nonsustained VT plus VF was 16 +/- 5 episodes per h (n = 6) in the Ad.beta gal group, 22 +/- 6 …
The setpoint study (ACTG A5217): effect of immediate versus deferred antiretroviral therapy on virologic set point in recently HIV-1-infected individuals.
Hogan CM, Degruttola V, Sun X, Fiscus SA, Del Rio C, Hare CB, Markowitz M, Connick E, Macatangay B, Tashima KT, Kallungal B, Camp R, Morton T, Daar ES, Little S; A5217 Study Team. Hogan CM, et al. J Infect Dis. 2012 Jan 1;205(1):87-96. doi: 10.1093/infdis/jir699. Epub 2011 Dec 15. J Infect Dis. 2012. PMID: 22180621 Free PMC article. Clinical Trial.
For the primary end point, the IT group at week 72 had a better outcome than the DT group at week 72 (P = .005) and the DT group at week 36 (P = .002). The differences were primarily due to the higher rate of progression to needing treatment in the DT group (50%) ve …
For the primary end point, the IT group at week 72 had a better outcome than the DT group at week 72 (P = .005) and the DT group at w …
11 results