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Page 1
Clostridioides difficile Infection in Children: A 5-Year Multicenter Retrospective Study.
Buonsenso D, Graffeo R, Pata D, Valentini P, Palumbo C, Masucci L, Ruggiero A, Attinà G, Onori M, Lancella L, Lucignano B, Giuseppe MD, Bernaschi P, Cursi L. Buonsenso D, et al. Front Pediatr. 2022 Apr 7;10:783098. doi: 10.3389/fped.2022.783098. eCollection 2022. Front Pediatr. 2022. PMID: 35463889 Free PMC article.

CDI children had a higher number of previous-day hospital admissions (p = 0.024), hospitalizations (p = 0.001), and total hospital admissions (p = 0.008). ...Previous use of proton pump inhibitors and antibiotics was associated with CDI (p < 0.001).

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CDI children had a higher number of previous-day hospital admissions (p = 0.024), hospitalizations (p = 0.001), and total hosp …
The burden of central line-associated bloodstream infections in children with medical complexity.
Scarselli A, Smarrazzo A, De Sanctis F, Ravà L, Carletti M, Ciofi Degli Atti M, Aversa M, Drago R, Crocoli A, Geremia C, Guerricchio A, Lucignano B, Campana A, De Ioris MA, Perrotta D. Scarselli A, et al. J Vasc Access. 2023 Mar;24(2):198-204. doi: 10.1177/11297298211027468. Epub 2021 Jun 21. J Vasc Access. 2023. PMID: 34148383

CLABSI incidence was 2.75/1000 CL-days (9 cases/3269 CL-days); incidence was 0 in patients without underling conditions and 3.14/1000 in CMC (p < 0.001). CLABSI were due to gram negative bacteria in five patients, Candida spp in three and Staphylococcus hominis in one.

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CLABSI incidence was 2.75/1000 CL-days (9 cases/3269 CL-days); incidence was 0 in patients without underling conditions and 3.14/1000 in CMC …
First Case of VIM-1-like-Producing Pseudomonas putida Bacteremia in an Oncohematological Pediatric Patient in Italy.
Cortazzo V, Agosta M, Gaspari S, Vrenna G, Lucignano B, Onori M, Di Ruscio V, Mancinelli L, Domo D, Perno CF, Bernaschi P. Cortazzo V, et al. Antibiotics (Basel). 2023 Jun 9;12(6):1033. doi: 10.3390/antibiotics12061033. Antibiotics (Basel). 2023. PMID: 37370352 Free PMC article.
To date, two cases of VIM-2 metallo-beta-lactamase (MBL)-producing Pseudomonas putida bacteremia have been ever reported in France and Spain between 2004 and 2010. Here, we present the first case of VIM-1-like-producing P. putida isolated in blood culture collected from an …
To date, two cases of VIM-2 metallo-beta-lactamase (MBL)-producing Pseudomonas putida bacteremia have been ever reported in France and Spain …
Effective Rapid Diagnosis of Bacterial and Fungal Bloodstream Infections by T2 Magnetic Resonance Technology in the Pediatric Population.
Lucignano B, Cento V, Agosta M, Ambrogi F, Albitar-Nehme S, Mancinelli L, Mattana G, Onori M, Galaverna F, Di Chiara L, Fragasso T, Bianchi R, Tortora F, Auriti C, Dotta A, Cecchetti C, Perdichizzi S, Raponi M, Onetti Muda A, Nerini Molteni S, Villani A, Locatelli F, Perno CF, Bernaschi P. Lucignano B, et al. J Clin Microbiol. 2022 Oct 19;60(10):e0029222. doi: 10.1128/jcm.00292-22. Epub 2022 Sep 7. J Clin Microbiol. 2022. PMID: 36069557 Free PMC article.

T2Bacteria and T2Candida provided definitive microorganism identification in a mean time of 4.4 and 3.7 h, respectively, versus 65.7 and 125.5 h for BCs (P < 0.001). T2 panels rapidly and accurately enable a diagnosis of a pediatric BSI, even in children under 1 year of

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T2Bacteria and T2Candida provided definitive microorganism identification in a mean time of 4.4 and 3.7 h, respectively, versus 65.7 and 125 …
Parenteral Nutrition Is One of the Most Significant Risk Factors for Nosocomial Infections in a Pediatric Cardiac Intensive Care Unit.
Netto R, Mondini M, Pezzella C, Romani L, Lucignano B, Pansani L, D'argenio P, Cogo P. Netto R, et al. JPEN J Parenter Enteral Nutr. 2017 May;41(4):612-618. doi: 10.1177/0148607115619416. Epub 2015 Nov 29. JPEN J Parenter Enteral Nutr. 2017. PMID: 26616137

RESULTS: Ninety-two patients (8.3%) had NIs. Overall mortality was 2% but 8.3% in children with NIs ( P < .001). The most frequent NIs were pneumonia (19.6%), bacteremia of unknown origin (16.3%), and catheter-associated bloodstream infection (14.1%) caused mainly by St

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RESULTS: Ninety-two patients (8.3%) had NIs. Overall mortality was 2% but 8.3% in children with NIs ( P < .001). The most frequent

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Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis.
Lucignano B, Ranno S, Liesenfeld O, Pizzorno B, Putignani L, Bernaschi P, Menichella D. Lucignano B, et al. J Clin Microbiol. 2011 Jun;49(6):2252-8. doi: 10.1128/JCM.02460-10. Epub 2011 Apr 6. J Clin Microbiol. 2011. PMID: 21471340 Free PMC article.
SeptiFast identified 97 additional isolates that blood culture failed to detect (24.7% P. aeruginosa, 23.7% CoNS, 14.4% Klebsiella spp., 14.4% Candida spp.). Among specimens taken from patients receiving antibiotic therapy, we also observed a significantly higher rate of p …
SeptiFast identified 97 additional isolates that blood culture failed to detect (24.7% P. aeruginosa, 23.7% CoNS, 14.4% Klebsiella sp …