Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial.
Cremolini C, Antoniotti C, Rossini D, Lonardi S, Loupakis F, Pietrantonio F, Bordonaro R, Latiano TP, Tamburini E, Santini D, Passardi A, Marmorino F, Grande R, Aprile G, Zaniboni A, Murgioni S, Granetto C, Buonadonna A, Moretto R, Corallo S, Cordio S, Antonuzzo L, Tomasello G, Masi G, Ronzoni M, Di Donato S, Carlomagno C, Clavarezza M, Ritorto G, Mambrini A, Roselli M, Cupini S, Mammoliti S, Fenocchio E, Corgna E, Zagonel V, Fontanini G, Ugolini C, Boni L, Falcone A; GONO Foundation Investigators.
Cremolini C, et al.
Lancet Oncol. 2020 Apr;21(4):497-507. doi: 10.1016/S1470-2045(19)30862-9. Epub 2020 Mar 9.
Lancet Oncol. 2020.
PMID: 32164906
Free article.
Clinical Trial.
Median progression-free survival 2 was 19.2 months (95% CI 17.3-21.4) in the experimental group and 16.4 months (15.1-17.5) in the control group (hazard ratio [HR] 0.74, 95% CI 0.63-0.88; p=0.0005). During the first-line treatment, the most frequent of all-cause grade 3-4 …
Median progression-free survival 2 was 19.2 months (95% CI 17.3-21.4) in the experimental group and 16.4 months (15.1-17.5) in the control g …