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495 results

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Page 1
Showing results for paul ssdna
Search for Paul Ssuna instead (3 results)
Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair.
Yu J, Yan C, Paul T, Brewer L, Tsutakawa SE, Tsai CL, Hamdan SM, Tainer JA, Ivanov I. Yu J, et al. Nat Commun. 2024 Oct 1;15(1):8511. doi: 10.1038/s41467-024-52860-y. Nat Commun. 2024. PMID: 39353945 Free PMC article.
Here TFIIH serves as a molecular ruler, defining the DNA bubble size and precisely positioning the XPG and XPF nucleases for incision. Using simulations and graph theoretical analyses, we unveil PInC's assembly, global motions, and partitioning into dynamic communities. Re …
Here TFIIH serves as a molecular ruler, defining the DNA bubble size and precisely positioning the XPG and XPF nucleases for incision …
Microviruses: A World Beyond phiX174.
Kirchberger PC, Ochman H. Kirchberger PC, et al. Annu Rev Virol. 2023 Sep 29;10(1):99-118. doi: 10.1146/annurev-virology-100120-011239. Annu Rev Virol. 2023. PMID: 37774127 Free article. Review.
Two decades of metagenomic analyses have revealed that in many environments, small (5 kb), single-stranded DNA phages of the family Microviridae dominate the virome. Although the emblematic microvirus phiX174 is ubiquitous in the laboratory, most other microv …
Two decades of metagenomic analyses have revealed that in many environments, small (5 kb), single-stranded DNA phages o …
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks.
Cristini A, Ricci G, Britton S, Salimbeni S, Huang SN, Marinello J, Calsou P, Pommier Y, Favre G, Capranico G, Gromak N, Sordet O. Cristini A, et al. Cell Rep. 2019 Sep 17;28(12):3167-3181.e6. doi: 10.1016/j.celrep.2019.08.041. Cell Rep. 2019. PMID: 31533039 Free PMC article.
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding of how transcription produces DNA double-strand breaks (DSBs) is limited. ...Here, we report a mechanism of their formation by showi …
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding …
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint.
Li L, Wang J, Yang Z, Zhao Y, Jiang H, Jiang L, Hou W, Ye R, He Q, Kupiec M, Luke B, Cao Q, Qi Z, Li Z, Lou H. Li L, et al. EMBO J. 2022 Feb 15;41(4):e108290. doi: 10.15252/embj.2021108290. Epub 2022 Jan 14. EMBO J. 2022. PMID: 35028974 Free PMC article.
Nucleotide metabolism fuels normal DNA replication and is also primarily targeted by the DNA replication checkpoint when replication stalls. ...Surprisingly, NADPH produced by the PPP is required for efficient recruitment of replication protein A (RPA) to single …
Nucleotide metabolism fuels normal DNA replication and is also primarily targeted by the DNA replication checkpoint when repli …
Celebrating complementarity.
Hoagland MB. Hoagland MB. Ann Intern Med. 2003 Apr 1;138(7):583-6. doi: 10.7326/0003-4819-138-7-200304010-00016. Ann Intern Med. 2003. PMID: 12667030
Watson and Crick raised the curtain by revealing the structure of DNA, notably the complementary pairing of the nucleotides in its twin chains. Identified with the new field of molecular biology, Crick defined and expanded the field of genetic information coding and led at …
Watson and Crick raised the curtain by revealing the structure of DNA, notably the complementary pairing of the nucleotides in its tw …
ssDNA degradation along capillary electrophoresis process using a Tris buffer.
Ric A, Ong-Meang V, Poinsot V, Martins-Froment N, Chauvet F, Boutonnet A, Ginot F, Ecochard V, Paquereau L, Couderc F. Ric A, et al. Electrophoresis. 2017 Jun;38(12):1624-1631. doi: 10.1002/elps.201600561. Epub 2017 Mar 20. Electrophoresis. 2017. PMID: 28251659 Free article.
Tris-Acetate buffer is currently used in the selection and the characterization of ssDNA by capillary electrophoresis (CE). By applying high voltage, the migration of ionic species into the capillary generates a current that induces water electrolysis. ...By injecting ten …
Tris-Acetate buffer is currently used in the selection and the characterization of ssDNA by capillary electrophoresis (CE). By applyi …
Biomedical applications of nanoflares: Targeted intracellular fluorescence probes.
Chenab KK, Eivazzadeh-Keihan R, Maleki A, Pashazadeh-Panahi P, Hamblin MR, Mokhtarzadeh A. Chenab KK, et al. Nanomedicine. 2019 Apr;17:342-358. doi: 10.1016/j.nano.2019.02.006. Epub 2019 Feb 28. Nanomedicine. 2019. PMID: 30826476 Free PMC article. Review.
Nanoflares are intracellular probes consisting of oligonucleotides immobilized on various nanoparticles that can recognize intracellular nucleic acids or other analytes, thus releasing a fluorescent reporter dye. Single-stranded DNA (ssDNA) complementa …
Nanoflares are intracellular probes consisting of oligonucleotides immobilized on various nanoparticles that can recognize intracellular nuc …
Structure of an RNA G-quadruplex from the West Nile virus genome.
Terrell JR, Le TT, Paul A, Brinton MA, Wilson WD, Poon GMK, Germann MW, Siemer JL. Terrell JR, et al. Nat Commun. 2024 Jun 26;15(1):5428. doi: 10.1038/s41467-024-49761-5. Nat Commun. 2024. PMID: 38926367 Free PMC article.
Potential G-quadruplex sites have been identified in the genomes of DNA and RNA viruses and proposed as regulatory elements. The genus Orthoflavivirus contains arthropod-transmitted, positive-sense, single-stranded RNA viruses that cause significant human dis …
Potential G-quadruplex sites have been identified in the genomes of DNA and RNA viruses and proposed as regulatory elements. The genu …
Pol κ in replication checkpoint.
Maiorano D, Hoffmann JS. Maiorano D, et al. Cell Cycle. 2013 Dec 15;12(24):3713-4. doi: 10.4161/cc.26976. Epub 2013 Oct 28. Cell Cycle. 2013. PMID: 24189533 Free PMC article. No abstract available.
High-frequency transcription leads to rapid R-loop formation.
Palmer B, Lee CY, Yang L, Paul T, Myong S. Palmer B, et al. J Biol Chem. 2025 Jun;301(6):108514. doi: 10.1016/j.jbc.2025.108514. Epub 2025 Apr 16. J Biol Chem. 2025. PMID: 40250562 Free PMC article.
R-loops are transcriptionally generated three-stranded nucleic acid structures where the mRNA hybridizes with template DNA, leaving a displaced single-stranded non-template DNA loop. Previously, we demonstrated that R-loop and subsequent G-quadruplex f …
R-loops are transcriptionally generated three-stranded nucleic acid structures where the mRNA hybridizes with template DNA, leaving a …
495 results