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The following terms were not found in PubMed: phenphichcha, khongpermgoson
Page 1
Showing results for phenphichcha khongpermgoson anit in
Search for Penpichcha Khongpermgoson Sanit-in instead (1 results)
Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway.
Ma X, Zhang W, Chen Y, Hu Q, Wang Z, Jiang T, Zeng Y, Efferth T. Ma X, et al. Phytomedicine. 2024 Nov;134:156021. doi: 10.1016/j.phymed.2024.156021. Epub 2024 Sep 3. Phytomedicine. 2024. PMID: 39255724
OBJECTIVE: This research was intended to elucidate the function and mechanism of Paeoniflorin (PF) in ameliorating ANIT-induced pyroptosis in CT. METHODS: CT models were established in SD rats and HepG2 cells through ANIT treatment. ...CONCLUSION: PF exhibited a hep …
OBJECTIVE: This research was intended to elucidate the function and mechanism of Paeoniflorin (PF) in ameliorating ANIT-induced pyrop …
Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-κB/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress.
Wang MQ, Zhang KH, Liu FL, Zhou R, Zeng Y, Chen AL, Yu Y, Xia Q, Zhu CC, Lin CZ. Wang MQ, et al. Phytomedicine. 2024 Jan;122:155124. doi: 10.1016/j.phymed.2023.155124. Epub 2023 Sep 29. Phytomedicine. 2024. PMID: 38014837
PURPOSE: The present study aims to elucidate the protective effect of WED on Alpha-naphthylisothiocyanate (ANIT)-induced CLI mice, and to investigate its potential pharmacological mechanism. METHODS: The anit-cholestatic and hepatoprotective effects of WED were eval …
PURPOSE: The present study aims to elucidate the protective effect of WED on Alpha-naphthylisothiocyanate (ANIT)-induced CLI mice, an …
Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
Zhang Z, Zhong X, Shen H, Sheng L, Liangpunsakul S, Lok AS, Omary MB, Wang S, Rui L. Zhang Z, et al. Nat Commun. 2022 Aug 30;13(1):5111. doi: 10.1038/s41467-022-32575-8. Nat Commun. 2022. PMID: 36042192 Free PMC article.
We find that cholangiocyte NIK is upregulated in mice with cholestasis induced by bile duct ligation (BDL), 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), or alpha-naphtyl-isothiocyanate (ANIT). DDC, ANIT, or BDL induces ductular reaction, liver injury, inflammation …
We find that cholangiocyte NIK is upregulated in mice with cholestasis induced by bile duct ligation (BDL), 5-diethoxycarbonyl-1,4-dihydroco …
Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation.
Gao Q, Li G, Zu Y, Xu Y, Wang C, Xiang D, He W, Shang T, Cheng X, Liu D, Zhang C. Gao Q, et al. J Ethnopharmacol. 2024 Jan 30;319(Pt 1):117089. doi: 10.1016/j.jep.2023.117089. Epub 2023 Aug 26. J Ethnopharmacol. 2024. PMID: 37634749 Free article.
Wild-type mice were intragastrically alpha-naphthylisothiocyanate (ANIT) to establish an experimental model of intrahepatic cholestasis and Rg1 intervention, and then liver injury and cholestasis related indexes were detected. ...Results showed that Rg1 reversed the ANI …
Wild-type mice were intragastrically alpha-naphthylisothiocyanate (ANIT) to establish an experimental model of intrahepatic cholestas …
Herpetrione alleviates ANIT-induced cholestatic liver injury by targeting FXR to suppress NF-kappaB signaling.
Jing L, Liao Y, Zhan H, Chen Q, Wei X, Qiu Y, Meng F, Liao Z, Chen M. Jing L, et al. J Ethnopharmacol. 2026 Feb 10;356:120839. doi: 10.1016/j.jep.2025.120839. Epub 2025 Oct 30. J Ethnopharmacol. 2026. PMID: 41176140
AIM OF THE STUDY: Based on the traditional efficacy of Herpetospermum pedunculosum as well as the hepatoprotective activity of herpetrione, we aim to investigate the therapeutic effects and molecular mechanisms of herpetrione against alpha-naphthylisothiocyanate (ANIT)-ind …
AIM OF THE STUDY: Based on the traditional efficacy of Herpetospermum pedunculosum as well as the hepatoprotective activity of herpetrione, …
Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway.
Zhou HQ, Liu W, Wang J, Huang YQ, Li PY, Zhu Y, Wang JB, Ma X, Li RS, Wei SZ, Li K, Li HT, Li JY, Xiao XH, Zhao YL. Zhou HQ, et al. Biomed Pharmacother. 2017 May;89:696-704. doi: 10.1016/j.biopha.2017.02.084. Epub 2017 Mar 6. Biomed Pharmacother. 2017. PMID: 28267673
However, whether PF could protect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis by inhibiting apoptosis remains unclear. In this study, we mainly investigated the effect and anti-apoptosis mechanism of PF on cholestasis. ...Furthermore, the pro-apoptosis …
However, whether PF could protect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis by inhibiting apoptosis remains unc …
JiaGaSongTang improves chronic cholestasis via enhancing FXR-mediated bile acid metabolism.
He X, Zhou Y, Yu J, Huang Q, Chen Z, Xiao R, Liu C, Gui S, Xiong T. He X, et al. Phytomedicine. 2024 Jun;128:155347. doi: 10.1016/j.phymed.2024.155347. Epub 2024 Jan 8. Phytomedicine. 2024. PMID: 38493717
PURPOSE: To investigate the effect of JiaGaSongTang (JGST) and its blood-absorbed ingredient 6-gingerol on alpha-naphthylisothiocyanate (ANIT)-induced chronic cholestasis, as well as elucidate the underlying regulatory mechanism. METHODS: Chronic cholestasis was induced in …
PURPOSE: To investigate the effect of JiaGaSongTang (JGST) and its blood-absorbed ingredient 6-gingerol on alpha-naphthylisothiocyanate ( …
Xiaohuang Qudan decoction alleviates ANIT-induced cholestatic liver injury by inhibiting the JAK2/STAT3 pathway and regulating TH17/Treg.
Tan Z, Chen L, Ye Z, Lu Q. Tan Z, et al. Chin J Nat Med. 2025 Apr;23(4):457-470. doi: 10.1016/S1875-5364(25)60854-5. Chin J Nat Med. 2025. PMID: 40274348
To this end, the researchers used Sprague-Dawley (SD) rats and established a cholestatic liver injury model by oral administration of alpha-naphthylisothiocyanate (ANIT). The experimental group was divided into six groups: Control (CON), ANIT, ursodeoxycholic acid ( …
To this end, the researchers used Sprague-Dawley (SD) rats and established a cholestatic liver injury model by oral administration of alpha- …
Acute ANIT toxicity in male IL-10 knockout and wild-type mice.
Faiola B, Peterson RA, Kimbrough CL, Jordan HL, Cullen JM. Faiola B, et al. Toxicol Pathol. 2010 Aug;38(5):745-55. doi: 10.1177/0192623310374970. Epub 2010 Jul 8. Toxicol Pathol. 2010. PMID: 20616378
Unexpectedly, over the course of the study, there was a consistent tendency for ANIT-treated IL-10 KO mice to have less hepatocellular injury than WT mice. However, changes in the biliary epithelium differed in that there was more histologic evidence of inflammation and ne …
Unexpectedly, over the course of the study, there was a consistent tendency for ANIT-treated IL-10 KO mice to have less hepatocellula …
Involvement of glutathione in 1-naphthylisothiocyanate (ANIT) metabolism and toxicity to isolated hepatocytes.
Carpenter-Deyo L, Marchand DH, Jean PA, Roth RA, Reed DJ. Carpenter-Deyo L, et al. Biochem Pharmacol. 1991 Nov 6;42(11):2171-80. doi: 10.1016/0006-2952(91)90353-7. Biochem Pharmacol. 1991. PMID: 1958235
When dissolved in aqueous solutions at neutral pH, 95% of GS-ANIT dissociated to yield free ANIT and GSH. Under conditions designed to maximize formation and stability of GS-ANIT, GS-ANIT was found in the extracellular medium of hepatocytes treated wit …
When dissolved in aqueous solutions at neutral pH, 95% of GS-ANIT dissociated to yield free ANIT and GSH. Under conditions des …
879 results