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Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound.
Bruchhagen C, Jarick M, Mewis C, Hertlein T, Niemann S, Ohlsen K, Peters G, Planz O, Ludwig S, Ehrhardt C. Bruchhagen C, et al. Sci Rep. 2018 Jun 14;8(1):9114. doi: 10.1038/s41598-018-27445-7. Sci Rep. 2018. PMID: 29904167 Free PMC article.
To address these questions, we studied the anti-pathogen activity of ATR-002 in comparison to CI-1040, particularly, its impact on Staphylococcus aureus (S. aureus), which is a major cause of IV super-infections. We analysed IV and S. aureus titres in vitro during s …
To address these questions, we studied the anti-pathogen activity of ATR-002 in comparison to CI-1040, particularly, its impact on Staphyloc …