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Year Number of Results
1986 1
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2018 3
2019 2
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24 results

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Page 1
Glycocalyx dysregulation impairs blood-brain barrier in ageing and disease.
Shi SM, Suh RJ, Shon DJ, Garcia FJ, Buff JK, Atkins M, Li L, Lu N, Sun B, Luo J, To NS, Cheung TH, McNerney MW, Heiman M, Bertozzi CR, Wyss-Coray T. Shi SM, et al. Nature. 2025 Mar;639(8056):985-994. doi: 10.1038/s41586-025-08589-9. Epub 2025 Feb 26. Nature. 2025. PMID: 40011765 Free PMC article.
The blood-brain barrier (BBB) is highly specialized to protect the brain from harmful circulating factors in the blood and maintain brain homeostasis(1,2). The brain endothelial glycocalyx layer, a carbohydrate-rich meshwork composed primarily of proteoglycans, glycoprotei …
The blood-brain barrier (BBB) is highly specialized to protect the brain from harmful circulating factors in the blood and maintain b …
Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Paganoni S, Fournier CN, Macklin EA, Chibnik LB, Quintana M, Saville BR, Detry MA, Vestrucci M, Marion J, McGlothlin A, Ajroud-Driss S, Chase M, Pothier L, Harkey BA, Yu H, Sherman AV, Shefner JM, Hall M, Kittle G, Berry JD, Babu S, Andrews J, Dagostino D, Tustison E, Giacomelli E, Scirocco E, Alameda G, Locatelli E, Ho D, Quick A, Katz J, Heitzman D, Appel SH, Shroff S, Felice K, Maragakis NJ, Simmons Z, Miller TM, Olney N, Weiss MD, Goutman SA, Fernandes JA, Jawdat O, Owegi MA, Foster LA, Vu T, Ilieva H, Newman DS, Arcila-Londono X, Jackson CE, Ladha S, Heiman-Patterson T, Caress JB, Swenson A, Peltier A, Lewis R, Fee D, Elliott M, Bedlack R, Kasarskis EJ, Elman L, Rosenfeld J, Walk D, McIlduff C, Twydell P, Young E, Johnson K, Rezania K, Goyal NA, Cohen JA, Benatar M, Jones V, Glass J, Shah J, Beydoun SR, Wymer JP, Zilliox L, Nayar S, Pattee GL, Martinez-Thompson J, Harvey B, Patel S, Mahoney P, Duda PW, Cudkowicz ME; HEALEY ALS Platform Trial Study Group. Paganoni S, et al. JAMA Netw Open. 2025 Feb 3;8(2):e2459058. doi: 10.1001/jamanetworkopen.2024.59058. JAMA Netw Open. 2025. PMID: 39960672 Free PMC article. Clinical Trial.
Interventions for treating inadvertent postoperative hypothermia.
Warttig S, Alderson P, Campbell G, Smith AF. Warttig S, et al. Cochrane Database Syst Rev. 2014 Nov 20;2014(11):CD009892. doi: 10.1002/14651858.CD009892.pub2. Cochrane Database Syst Rev. 2014. PMID: 25411963 Free PMC article.
However, high-quality evidence on other important clinical outcomes is lacking; therefore it is unclear whether active warming offers other benefits and harms. High-quality evidence on other warming methods is also lacking; therefore it is unclear whether other rewarming m …
However, high-quality evidence on other important clinical outcomes is lacking; therefore it is unclear whether active warming offers other …
Dynamic role of macrophage CX3CR1 expression in inflammatory bowel disease.
Li J, Zhou H, Fu X, Zhang M, Sun F, Fan H. Li J, et al. Immunol Lett. 2021 Apr;232:39-44. doi: 10.1016/j.imlet.2021.02.001. Epub 2021 Feb 11. Immunol Lett. 2021. PMID: 33582183 Review.
Accumulating evidence suggests that CX3CR1(+) macrophages are critical for mucosal homeostasis and IBD pathogenesis, while some conflicts exist in current studies with both protective and harmful effects being revealed. Herein, we reviewed published literatures and found t …
Accumulating evidence suggests that CX3CR1(+) macrophages are critical for mucosal homeostasis and IBD pathogenesis, while some conflicts ex …
Ketamine as an adjuvant to opioids for cancer pain.
Bell RF, Eccleston C, Kalso EA. Bell RF, et al. Cochrane Database Syst Rev. 2017 Jun 28;6(6):CD003351. doi: 10.1002/14651858.CD003351.pub3. Cochrane Database Syst Rev. 2017. PMID: 28657160 Free PMC article.
AUTHORS' CONCLUSIONS: Current evidence is insufficient to assess the benefits and harms of ketamine as an adjuvant to opioids for the relief of refractory cancer pain. ...
AUTHORS' CONCLUSIONS: Current evidence is insufficient to assess the benefits and harms of ketamine as an adjuvant to opioids for the …
Intravenous nutrients for preventing inadvertent perioperative hypothermia in adults.
Warttig S, Alderson P, Lewis SR, Smith AF. Warttig S, et al. Cochrane Database Syst Rev. 2016 Nov 22;11(11):CD009906. doi: 10.1002/14651858.CD009906.pub2. Cochrane Database Syst Rev. 2016. PMID: 27875631 Free PMC article.
It is also unclear whether amino acids have any effect on the risk of shivering and if intravenous nutrients confer any other benefits or harms, as high-quality data about these outcomes are lacking....
It is also unclear whether amino acids have any effect on the risk of shivering and if intravenous nutrients confer any other benefits or …
AI generates covertly racist decisions about people based on their dialect.
Hofmann V, Kalluri PR, Jurafsky D, King S. Hofmann V, et al. Nature. 2024 Sep;633(8028):147-154. doi: 10.1038/s41586-024-07856-5. Epub 2024 Aug 28. Nature. 2024. PMID: 39198640 Free PMC article.
Dialect prejudice has the potential for harmful consequences: language models are more likely to suggest that speakers of AAE be assigned less-prestigious jobs, be convicted of crimes and be sentenced to death. ...
Dialect prejudice has the potential for harmful consequences: language models are more likely to suggest that speakers of AAE be assi …
Embolization of Ruptured Infratentorial Pial AVM in Pregnancy.
Zeleňák K, Šalát D, Kolarovszki B, Kurča E, Zeleňáková J, Koçer N. Zeleňák K, et al. Life (Basel). 2023 Mar 28;13(4):896. doi: 10.3390/life13040896. Life (Basel). 2023. PMID: 37109425 Free PMC article.
Complete occlusion of the AVM was achieved by embolization with PHIL (precipitating hydrophobic injectable liquid). The calculated dose in the uterus was less than 1 Sv, which represents a negligible risk of harmful effects on the fetus. ...
Complete occlusion of the AVM was achieved by embolization with PHIL (precipitating hydrophobic injectable liquid). The calculated do …
Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermia.
Campbell G, Alderson P, Smith AF, Warttig S. Campbell G, et al. Cochrane Database Syst Rev. 2015 Apr 13;2015(4):CD009891. doi: 10.1002/14651858.CD009891.pub2. Cochrane Database Syst Rev. 2015. PMID: 25866139 Free PMC article.
It is unclear whether the actual differences in temperature are clinically meaningful, or if other benefits or harms are associated with the use of warmed fluids. It is also unclear if using fluid warming in addition to other warming methods confers any benefit, as a ceili …
It is unclear whether the actual differences in temperature are clinically meaningful, or if other benefits or harms are associated w …
Ethical and Legal Implications of Frailty Screening.
Reid L, Lahey W, Livingstone B, McNally M. Reid L, et al. J Frailty Aging. 2018;7(4):224-232. doi: 10.14283/jfa.2018.31. J Frailty Aging. 2018. PMID: 30298170 Free PMC article.
Goals of screening for frailty include (a) promoting healthy aging, (b) addressing frailty with preventive and targeted interventions, (c) better aligning social and medical responses to frailty with the needs of frail older adults and (d) preventing harms to frail older a …
Goals of screening for frailty include (a) promoting healthy aging, (b) addressing frailty with preventive and targeted interventions, (c) b …
24 results