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44 results

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Page 1
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG. Elhassan YS, et al. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043. Cell Rep. 2019. PMID: 31412242 Free PMC article. Clinical Trial.
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Parker CC, Kynaston H, Cook AD, Clarke NW, Catton CN, Cross WR, Petersen PM, Persad RA, Pugh CA, Saad F, Logue J, Payne H, Bower LC, Brawley C, Rauchenberger M, Barkati M, Bottomley DM, Brasso K, Chung HT, Chung PWM, Conroy R, Falconer A, Ford V, Goh CL, Heath CM, James ND, Kim-Sing C, Kodavatiganti R, Malone SC, Morris SL, Nabid A, Ong AD, Raman R, Rodda S, Wells P, Worlding J, Parulekar WR, Parmar MKB, Sydes MR; RADICALS investigators. Parker CC, et al. Lancet. 2024 Jun 1;403(10442):2416-2425. doi: 10.1016/S0140-6736(24)00549-X. Epub 2024 May 16. Lancet. 2024. PMID: 38763153 Free PMC article. Clinical Trial.
Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination.
Philp AR, Reyes CR, Mansilla J, Sharma A, Zhao C, Valenzuela-Krugmann C, Rawji KS, Gonzalez Martinez GA, Dimas P, Hinrichsen B, Ulloa-Leal C, Waller AK, Bessa de Sousa DM, Castro MA, Aigner L, Ehrenfeld P, Silva ME, Kazanis I, Ghevaert C, Franklin RJM, Rivera FJ. Philp AR, et al. Elife. 2024 Aug 20;12:RP91757. doi: 10.7554/eLife.91757. Elife. 2024. PMID: 39163103 Free PMC article.
Partial depletion of circulating platelets impaired OPC differentiation and remyelination, without altering blood-brain barrier stability and neuroinflammation. Transient exposure to platelets enhanced OPC differentiation in vitro, whereas sustained exposure suppressed thi …
Partial depletion of circulating platelets impaired OPC differentiation and remyelination, without altering blood-brain barrier stabi …
Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.
Nelson AT, Cicardi ME, Markandaiah SS, Han JY, Philp NJ, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. Nelson AT, et al. EMBO Rep. 2024 May;25(5):2479-2510. doi: 10.1038/s44319-024-00140-7. Epub 2024 Apr 29. EMBO Rep. 2024. PMID: 38684907 Free PMC article.
The most prevalent genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia is a (GGGGCC)(n) nucleotide repeat expansion (NRE) occurring in the first intron of the C9orf72 gene (C9). Brain glucose hypometabolism is consistently observed in C9-NRE car …
The most prevalent genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia is a (GGGGCC)(n) nucleotide repeat expans …
Novel retinal photoreceptors.
Soni BG, Philp AR, Foster RG, Knox BE. Soni BG, et al. Nature. 1998 Jul 2;394(6688):27-8. doi: 10.1038/27794. Nature. 1998. PMID: 9665123 No abstract available.
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Parker CC, Clarke NW, Cook AD, Kynaston H, Catton CN, Cross WR, Petersen PM, Persad RA, Saad F, Bower LC, Logue J, Payne H, Forcat S, Goldstein C, Murphy C, Anderson J, Barkati M, Bottomley DM, Branagan J, Choudhury A, Chung PWM, Cogley L, Goh CL, Hoskin P, Khoo V, Malone SC, Masters L, Morris SL, Nabid A, Ong AD, Raman R, Tarver KL, Tree AC, Worlding J, Wylie JP, Zarkar AM, Parulekar WR, Parmar MKB, Sydes MR; RADICALS investigators. Parker CC, et al. Lancet. 2024 Jun 1;403(10442):2405-2415. doi: 10.1016/S0140-6736(24)00548-8. Epub 2024 May 16. Lancet. 2024. PMID: 38763154 Free PMC article. Clinical Trial.
Immune responses drive chorioretinitis and retinal pathology after neonatal CMV infection.
McCord JL, Han JYS, Staudt RE, Philp NJ, Snyder CM. McCord JL, et al. Sci Adv. 2024 Nov 22;10(47):eadn6379. doi: 10.1126/sciadv.adn6379. Epub 2024 Nov 20. Sci Adv. 2024. PMID: 39565860 Free PMC article.
Human cytomegalovirus (CMV) causes a common congenital infection leading to long-term neurological impairments including brain, cochlear, and ocular pathology. Infection of newborn mice with murine (M)CMV is an established model of neuropathology caused by congenital CMV i …
Human cytomegalovirus (CMV) causes a common congenital infection leading to long-term neurological impairments including brain, cochl …
Outcomes in patients with gunshot wounds to the brain.
Robinson LA, Turco LM, Robinson B, Corsa JG, Mount M, Hamrick AV, Berne J, Mederos DR, McNickle AG, Chestovich PJ, Weinberger J, Grigorian A, Nahmias J, Lee JK, Chow KL, Olson EJ, Pascual JL, Solomon R, Pigneri DA, Ladhani HA, Fraifogl J, Claridge J, Curry T, Costantini TW, Kongwibulwut M, Kaafarani H, San Roman J, Schreiber C, Goldenberg-Sandau A, Hu P, Bosarge P, Uhlich R, Lunardi N, Usmani F, Sakran JV, Babcock JM, Quispe JC, Lottenberg L, Cabral D, Chang G, Gulmatico J, Parks JJ, Rattan R, Massetti J, Gurney O, Bruns B, Smith AA, Guidry C, Kutcher ME, Logan MS, Kincaid MY, Spalding C, Noorbaksh M, Philp FH, Cragun B, Winfield RD. Robinson LA, et al. Trauma Surg Acute Care Open. 2019 Nov 17;4(1):e000351. doi: 10.1136/tsaco-2019-000351. eCollection 2019. Trauma Surg Acute Care Open. 2019. PMID: 31799416 Free PMC article.
INTRODUCTION: Gunshot wounds to the brain (GSWB) confer high lethality and uncertain recovery. It is unclear which patients benefit from aggressive resuscitation, and furthermore whether patients with GSWB undergoing cardiopulmonary resuscitation (CPR) have potential for s …
INTRODUCTION: Gunshot wounds to the brain (GSWB) confer high lethality and uncertain recovery. It is unclear which patients benefit f …
Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy.
Sanders KA, Philp JAC, Jordan CY, Cale AS, Cunningham CL, Organ JM. Sanders KA, et al. PLoS One. 2022 Jun 9;17(6):e0267550. doi: 10.1371/journal.pone.0267550. eCollection 2022. PLoS One. 2022. PMID: 35679263 Free PMC article.
This study reports the results of Anatomy Nights brain events held at four different venues in the UK and USA in 2018 and 2019. Two general questions were asked of the data: 1) Do participant post-event test scores differ from pre-event scores; and 2) Are there differences …
This study reports the results of Anatomy Nights brain events held at four different venues in the UK and USA in 2018 and 2019. Two g …
44 results