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Year Number of Results
1917 1
1946 58
1947 89
1948 171
1949 88
1950 453
1951 463
1952 773
1953 1037
1954 1474
1955 1441
1956 1547
1957 1458
1958 1145
1959 1283
1960 1346
1961 1493
1962 1694
1963 2064
1964 2288
1965 2398
1966 2804
1967 2428
1968 2754
1969 2990
1970 2930
1971 3133
1972 3123
1973 3014
1974 3011
1975 2947
1976 2979
1977 2827
1978 2737
1979 2835
1980 2655
1981 2144
1982 1837
1983 1832
1984 2023
1985 1860
1986 1943
1987 2062
1988 2065
1989 1702
1990 1533
1991 1603
1992 2049
1993 1987
1994 1764
1995 2039
1996 1970
1997 1731
1998 1950
1999 1964
2000 2364
2001 2401
2002 2400
2003 2836
2004 2757
2005 2730
2006 2591
2007 2488
2008 2610
2009 2652
2010 2707
2011 2934
2012 3028
2013 2960
2014 2955
2015 3058
2016 3029
2017 2858
2018 2676
2019 2606
2020 2868
2021 3141
2022 2924
2023 2819
2024 2723
2025 983

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168,732 results

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The following term was not found in PubMed: Olivella-Rosell
Page 1
Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Su BG, Vos SM. Su BG, et al. Mol Cell. 2024 Apr 4;84(7):1243-1256.e5. doi: 10.1016/j.molcel.2024.01.023. Epub 2024 Feb 23. Mol Cell. 2024. PMID: 38401543 Free PMC article.
Upon depletion of elongation factors, NELF appears to accompany elongating Pol II past pause sites; however, prior work indicates that NELF prevents Pol II elongation. ...Our results define how NELF can support pausing, reactivation, and elongation by Pol II. …
Upon depletion of elongation factors, NELF appears to accompany elongating Pol II past pause sites; however, prior work indicates tha …
Eukaryotic DNA polymerases.
Hubscher U, Maga G, Spadari S. Hubscher U, et al. Annu Rev Biochem. 2002;71:133-63. doi: 10.1146/annurev.biochem.71.090501.150041. Epub 2001 Nov 9. Annu Rev Biochem. 2002. PMID: 12045093 Review.
In the last few years the number of known pols, including terminal transferase and telomerase, has increased to at least 19. A particular pol might have more than one functional task in a cell and a particular DNA synthetic event may require more than one pol, which …
In the last few years the number of known pols, including terminal transferase and telomerase, has increased to at least 19. A particular …
Never a dull enzyme, RNA polymerase II.
Huang J, Ji X. Huang J, et al. Transcription. 2023 Nov;14(1-2):49-67. doi: 10.1080/21541264.2023.2208023. Epub 2023 May 2. Transcription. 2023. PMID: 37132022 Free PMC article. Review.
RNA polymerase II (Pol II) is composed of 12 subunits that collaborate to synthesize mRNA within the nucleus. ...By regulating these processes in a coordinated manner through its subunits, Pol II can optimize its activity for diverse biological functions. Here, we r …
RNA polymerase II (Pol II) is composed of 12 subunits that collaborate to synthesize mRNA within the nucleus. ...By regulating these …
Evidence of RNA polymerase III recruitment and transcription at protein-coding gene promoters.
K C R, Cheng R, Zhou S, Lizarazo S, Smith DJ, Van Bortle K. K C R, et al. Mol Cell. 2024 Nov 7;84(21):4111-4124.e5. doi: 10.1016/j.molcel.2024.09.019. Epub 2024 Oct 10. Mol Cell. 2024. PMID: 39393362
Taken further, RNA Pol III disruption generally reduces the expression of RNA Pol III-occupied protein-coding genes, suggesting RNA Pol III recruitment and transcription enhance RNA Pol II activity. These findings resemble analogous patterns of RNA …
Taken further, RNA Pol III disruption generally reduces the expression of RNA Pol III-occupied protein-coding genes, suggestin …
Translesion DNA Synthesis and Carcinogenesis.
Shilkin ES, Boldinova EO, Stolyarenko AD, Goncharova RI, Chuprov-Netochin RN, Khairullin RF, Smal MP, Makarova AV. Shilkin ES, et al. Biochemistry (Mosc). 2020 Apr;85(4):425-435. doi: 10.1134/S0006297920040033. Biochemistry (Mosc). 2020. PMID: 32569550 Review.
DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol iota), eta (Pol eta), kappa (Pol kappa), and zeta (Pol zeta) have active sites that are less stringent toward the DNA template str …
DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol iota), eta …
RNA Polymerase III, Ageing and Longevity.
Kulaberoglu Y, Malik Y, Borland G, Selman C, Alic N, Tullet JMA. Kulaberoglu Y, et al. Front Genet. 2021 Jul 6;12:705122. doi: 10.3389/fgene.2021.705122. eCollection 2021. Front Genet. 2021. PMID: 34295356 Free PMC article. Review.
In this review we introduce the Pol III transcription apparatus and review the current understanding of RNA Pol III's role in ageing and lifespan in different model organisms. We then discuss the potential of Pol III as a therapeutic target to improve age-rel …
In this review we introduce the Pol III transcription apparatus and review the current understanding of RNA Pol III's role in …
RNA Polymerases I and III in development and disease.
Watt KE, Macintosh J, Bernard G, Trainor PA. Watt KE, et al. Semin Cell Dev Biol. 2023 Feb 28;136:49-63. doi: 10.1016/j.semcdb.2022.03.027. Epub 2022 Apr 11. Semin Cell Dev Biol. 2023. PMID: 35422389 Free PMC article. Review.
Furthermore, pathogenic variants in genes encoding subunits shared between Pol I and Pol III give rise to distinct syndromes depending on whether Pol I or Pol III function is disrupted. In this review, we discuss the global roles of Pol I and II …
Furthermore, pathogenic variants in genes encoding subunits shared between Pol I and Pol III give rise to distinct syndromes d …
Replicative DNA polymerase mutations in cancer.
Heitzer E, Tomlinson I. Heitzer E, et al. Curr Opin Genet Dev. 2014 Feb;24(100):107-13. doi: 10.1016/j.gde.2013.12.005. Epub 2014 Feb 26. Curr Opin Genet Dev. 2014. PMID: 24583393 Free PMC article. Review.
Three DNA polymerases - Pol alpha, Pol delta and Pol e - are essential for DNA replication. After initiation of DNA synthesis by Pol alpha, Pol delta or Pol e take over on the lagging and leading strand respectively. Pol delta and …
Three DNA polymerases - Pol alpha, Pol delta and Pol e - are essential for DNA replication. After initiation of DNA syn …
Two forms of human DNA polymerase δ: Who does what and why?
Lee MYWT, Zhang S, Wang X, Chao HH, Zhao H, Darzynkiewicz Z, Zhang Z, Lee EYC. Lee MYWT, et al. DNA Repair (Amst). 2019 Sep;81:102656. doi: 10.1016/j.dnarep.2019.102656. Epub 2019 Jul 8. DNA Repair (Amst). 2019. PMID: 31326365 Review.
Recent studies of cells in which p12 expression is ablated, and are therefore null for Pol delta4, show that Pol delta4 is not required for cell viability. These cells have a defect in homologous recombination, revealing a specific role for Pol delta4 that ca …
Recent studies of cells in which p12 expression is ablated, and are therefore null for Pol delta4, show that Pol delta4 is not …
Non-coding RNA polymerases that silence transposable elements and reprogram gene expression in plants.
Rymen B, Ferrafiat L, Blevins T. Rymen B, et al. Transcription. 2020 Jun-Aug;11(3-4):172-191. doi: 10.1080/21541264.2020.1825906. Epub 2020 Nov 12. Transcription. 2020. PMID: 33180661 Free PMC article. Review.
Multisubunit RNA polymerase (Pol) complexes are the core machinery for gene expression in eukaryotes. The enzymes Pol I, Pol II and Pol III transcribe distinct subsets of nuclear genes. This family of nuclear RNA polymerases expanded in terrestrial pla …
Multisubunit RNA polymerase (Pol) complexes are the core machinery for gene expression in eukaryotes. The enzymes Pol I, Po …
168,732 results
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