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Modelling and drug targeting of a myeloid neoplasm with atypical 3q26/MECOM rearrangement using patient-specific iPSCs.
Nakamura M, Chonabayashi K, Narita M, Matsumura Y, Nishikawa M, Ochi Y, Nannya Y, Hishizawa M, Inoue D, Delwel R, Ogawa S, Takaori-Kondo A, Yoshida Y. Nakamura M, et al. Br J Haematol. 2024 Oct;205(4):1430-1443. doi: 10.1111/bjh.19720. Epub 2024 Aug 26. Br J Haematol. 2024. PMID: 39187468
Our iPSC model reproduced the primary patient's MECOM expression changes and histone H3 lysine 27 acetylation (H3K27ac) patterns in the MECOM promoter and MYC blood enhancer cluster (BENC). Furthermore, we revealed the apoptotic effects of the bromodomain and extra-termina …
Our iPSC model reproduced the primary patient's MECOM expression changes and histone H3 lysine 27 acetylation (H3K27ac) patterns in the MECO …
Synthesis of sulfonylhydrazone- and acylhydrazone-substituted 8-ethoxy-3-nitro-2H-chromenes as potent antiproliferative and apoptosis inducing agents.
Zhang D, Ma Y, Liu Y, Liu ZP. Zhang D, et al. Arch Pharm (Weinheim). 2014 Aug;347(8):576-88. doi: 10.1002/ardp.201400082. Epub 2014 May 27. Arch Pharm (Weinheim). 2014. PMID: 24866448
All the tested compounds exhibited more potent antiproliferative activity than BENC-511 against KG-1 cells. These compounds displayed IC50 values in the nanomolar range against A2780 cells. Compound 7d showed prominent cytotoxicity against K562 cells with an IC50 of 0.11 M …
All the tested compounds exhibited more potent antiproliferative activity than BENC-511 against KG-1 cells. These compounds displayed …
Microaerobic degradation of crude oil and long chain alkanes by a new Rhodococcus strain from Gulf of Mexico.
Juárez K, Reza L, Bretón-Deval L, Morales-Guzmán D, Trejo-Hernández MR, García-Guevara F, Lara P. Juárez K, et al. World J Microbiol Biotechnol. 2023 Jul 29;39(10):264. doi: 10.1007/s11274-023-03703-3. World J Microbiol Biotechnol. 2023. PMID: 37515608 Free PMC article.
Genome analysis revealed the presence of several genes related to aromatic compound degradation, such as benA, benB, benC, catA, catB, and catC; and five alkB genes related to alkane degradation. Although members of the genus Rhodococcus are well known for their great meta …
Genome analysis revealed the presence of several genes related to aromatic compound degradation, such as benA, benB, benC, catA, catB …