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13 results

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Page 1
A genetic score for the prediction of beta-thalassemia severity.
Danjou F, Francavilla M, Anni F, Satta S, Demartis FR, Perseu L, Manca M, Sollaino MC, Manunza L, Mereu E, Marceddu G, Pissard S, Joly P, Thuret I, Origa R, Borg J, Forni GL, Piga A, Lai ME, Badens C, Moi P, Galanello R. Danjou F, et al. Haematologica. 2015 Apr;100(4):452-7. doi: 10.3324/haematol.2014.113886. Epub 2014 Dec 5. Haematologica. 2015. PMID: 25480500 Free PMC article.
Discriminatory power of the model was high (C-index=0.705; R(2)=0.343) and the validation conducted on the testing set confirmed its predictive accuracy with transfusion-free survival probability (P<0.001) and with transfusion dependency status (Area Under the Receiver …
Discriminatory power of the model was high (C-index=0.705; R(2)=0.343) and the validation conducted on the testing set confirmed its …
Performance characteristics and clinical utility of an enzymatic method for the measurement of glycated albumin in plasma.
Paroni R, Ceriotti F, Galanello R, Battista Leoni G, Panico A, Scurati E, Paleari R, Chemello L, Quaino V, Scaldaferri L, Lapolla A, Mosca A. Paroni R, et al. Clin Biochem. 2007 Dec;40(18):1398-405. doi: 10.1016/j.clinbiochem.2007.08.001. Epub 2007 Aug 10. Clin Biochem. 2007. PMID: 17919531 Free article.
The correlations between glycated albumin and HbA(1c) were as follows: (a) type 2 diabetics: r(2)=0.483 (good glycemic control), r(2)=0.577 (poor control); (b) diabetic patients under dialysis: r(2)=0.480; (c) liver disease: r(2)=0.186; (d) transfused …
The correlations between glycated albumin and HbA(1c) were as follows: (a) type 2 diabetics: r(2)=0.483 (good glycemic control), r
Analytical evaluation of the Tosoh HLC-723 G7 automated HPLC analyzer for hemoglobin A2 and F determination.
Paleari R, Cannata M, Leto F, Maggio A, Demartis FR, Desogus MF, Galanello R, Mosca A. Paleari R, et al. Clin Biochem. 2005 Feb;38(2):159-65. doi: 10.1016/j.clinbiochem.2004.10.017. Clin Biochem. 2005. PMID: 15642279
The following results were obtained in two different laboratories: y = 1.163x - 0.52, r = 0.9918, n = 144 (Lab A); y = 1.060x - 0.40, r = 0.9920, n = 93 (Lab B). With regard to the determination of Hb F, the measurements performed by the tested method was found to c …
The following results were obtained in two different laboratories: y = 1.163x - 0.52, r = 0.9918, n = 144 (Lab A); y = 1.060x - 0.40, …
Relationship between transfusion regimen and suppression of erythropoiesis in beta-thalassaemia major.
Cazzola M, De Stefano P, Ponchio L, Locatelli F, Beguin Y, Dessi C, Barella S, Cao A, Galanello R. Cazzola M, et al. Br J Haematol. 1995 Mar;89(3):473-8. doi: 10.1111/j.1365-2141.1995.tb08351.x. Br J Haematol. 1995. PMID: 7734344

Multiple, regression analysis showed that serum transferrin receptor was the parameter more closely related to mean pretransfusion haemoglobin (r = -0.77, P < 0.001). As measured through serum transferrin receptor, erythroid activity was 1-2 times normal for pretransfus

Multiple, regression analysis showed that serum transferrin receptor was the parameter more closely related to mean pretransfusion haemoglob …
Simultaneous automated determination of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in whole blood.
Mosca A, Paleari R, Rosti E, Luzzana M, Barella S, Sollaino C, Galanello R. Mosca A, et al. Eur J Clin Chem Clin Biochem. 1996 May;34(5):431-8. doi: 10.1515/cclm.1996.34.5.431. Eur J Clin Chem Clin Biochem. 1996. PMID: 8790979
Results of glucose 6-phosphate dehydrogenase activity (U/l) in whole blood (y) correlated well with those obtained with the previously described monostarter assay, performed at pH 9.2 (y = 0.60x + 37; n = 80; r = 0.991). Results of 6-phosphogluconate dehydrogenase (U/l) in …
Results of glucose 6-phosphate dehydrogenase activity (U/l) in whole blood (y) correlated well with those obtained with the previously descr …
Serum erythropoietin and erythropoiesis in high- and low-fetal hemoglobin beta-thalassemia intermedia patients.
Galanello R, Barella S, Turco MP, Giagu N, Cao A, Dore F, Liberato NL, Guarnone R, Barosi G. Galanello R, et al. Blood. 1994 Jan 15;83(2):561-5. Blood. 1994. PMID: 7506955 Free article.
Log (s-Epo) was correlated inversely with Hb (r = -0.47; P < .01), and directly with HbF (r = .55; P < .001). Multivariate regression analysis showed that Hb and HbF were independently correlated with s-Epo levels. ...

Log (s-Epo) was correlated inversely with Hb (r = -0.47; P < .01), and directly with HbF (r = .55; P < .001). Multivaria

Genetic modifiers of β-thalassemia and clinical severity as assessed by age at first transfusion.
Danjou F, Anni F, Perseu L, Satta S, Dessì C, Lai ME, Fortina P, Devoto M, Galanello R. Danjou F, et al. Haematologica. 2012 Jul;97(7):989-93. doi: 10.3324/haematol.2011.053504. Epub 2012 Jan 22. Haematologica. 2012. PMID: 22271886 Free PMC article.
RESULTS: According to the resulting model, we were able to explain phenotypic severity to a large extent (Harrell's concordance index=0.72; Cox & Snell R(2)=0.394) and demonstrated that most of the model's discriminatory ability is attributable to the genetic variants …
RESULTS: According to the resulting model, we were able to explain phenotypic severity to a large extent (Harrell's concordance index=0.72; …
Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study.
Porter J, Galanello R, Saglio G, Neufeld EJ, Vichinsky E, Cappellini MD, Olivieri N, Piga A, Cunningham MJ, Soulières D, Gattermann N, Tchernia G, Maertens J, Giardina P, Kwiatkowski J, Quarta G, Jeng M, Forni GL, Stadler M, Cario H, Debusscher L, Della Porta M, Cazzola M, Greenberg P, Alimena G, Rabault B, Gathmann I, Ford JM, Alberti D, Rose C. Porter J, et al. Eur J Haematol. 2008 Feb;80(2):168-76. doi: 10.1111/j.1600-0609.2007.00985.x. Epub 2007 Nov 17. Eur J Haematol. 2008. PMID: 18028431 Free PMC article.
Changes in serum ferritin and LIC were correlated irrespective of disease group (r = 0.59), supporting the potential use of serum ferritin for monitoring deferasirox therapy. ...
Changes in serum ferritin and LIC were correlated irrespective of disease group (r = 0.59), supporting the potential use of serum fer …
Iron chelation therapy with deferasirox in patients with aplastic anemia: a subgroup analysis of 116 patients from the EPIC trial.
Lee JW, Yoon SS, Shen ZX, Ganser A, Hsu HC, Habr D, Domokos G, Roubert B, Porter JB; EPIC study investigators. Lee JW, et al. Blood. 2010 Oct 7;116(14):2448-54. doi: 10.1182/blood-2010-01-261289. Epub 2010 Jun 21. Blood. 2010. PMID: 20566896 Free article. Clinical Trial.
The decrease in mean alanine aminotransferase levels at 1 year correlated significantly with reduction in serum ferritin (r = 0.40, P < .001). Mean absolute neutrophil and platelet counts remained stable during treatment, and there were no drug-related cytopenias. ...
The decrease in mean alanine aminotransferase levels at 1 year correlated significantly with reduction in serum ferritin (r = 0.40, P …
Red cell pyruvate kinase deficiency in Southern Sardinia.
Perseu L, Giagu N, Satta S, Sollaino MC, Congiu R, Galanello R. Perseu L, et al. Blood Cells Mol Dis. 2010 Dec 15;45(4):280-3. doi: 10.1016/j.bcmd.2010.08.006. Epub 2010 Sep 25. Blood Cells Mol Dis. 2010. PMID: 20870434
We studied the clinical and hematological aspects of 3 patients and analyzed the following genes: pyruvate kinase-R, glucose-6-phosphate-dehydrogenase, alpha-globin, uridindiphosphoglucuronil transferase and HFE. ...
We studied the clinical and hematological aspects of 3 patients and analyzed the following genes: pyruvate kinase-R, glucose-6-phosph …
13 results