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Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein.
Gillard M, Chatelain P, Fuks B. Gillard M, et al. Eur J Pharmacol. 2006 Apr 24;536(1-2):102-8. doi: 10.1016/j.ejphar.2006.02.022. Epub 2006 Mar 10. Eur J Pharmacol. 2006. PMID: 16556440
., Massingham, R. Chatelain, P., 2003. Binding characteristics of [3H]ucb 30889 to levetiracetam binding sites in rat brain. ...
., Massingham, R. Chatelain, P., 2003. Binding characteristics of [3H]ucb 30889 to levetiracetam binding sites in rat brain. . …
PhyloSim - Monte Carlo simulation of sequence evolution in the R statistical computing environment.
Sipos B, Massingham T, Jordan GE, Goldman N. Sipos B, et al. BMC Bioinformatics. 2011 Apr 19;12:104. doi: 10.1186/1471-2105-12-104. BMC Bioinformatics. 2011. PMID: 21504561 Free PMC article.
RESULTS: PhyloSim is an extensible framework for the Monte Carlo simulation of sequence evolution, written in R, using the Gillespie algorithm to integrate the actions of many concurrent processes such as substitutions, insertions and deletions. ...CONCLUSIONS: Close integ …
RESULTS: PhyloSim is an extensible framework for the Monte Carlo simulation of sequence evolution, written in R, using the Gillespie …
Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu).
Gupta A, Chatelain P, Massingham R, Jonsson EN, Hammarlund-Udenaes M. Gupta A, et al. Drug Metab Dispos. 2006 Feb;34(2):318-23. doi: 10.1124/dmd.105.007211. Epub 2005 Nov 22. Drug Metab Dispos. 2006. PMID: 16303872
The objective of this study was to compare the blood-brain barrier (BBB) transport and brain distribution of levo- (R-CZE) and dextrocetirizine (S-CZE). ...The transport of the CZE enantiomers across the BBB was not stereoselective, since the K(p,uu) was 0.17 and 0.14 (N.S …
The objective of this study was to compare the blood-brain barrier (BBB) transport and brain distribution of levo- (R-CZE) and dextro …
Quantitative determination of cetirizine enantiomers in guinea pig plasma, brain tissue and microdialysis samples using liquid chromatography/tandem mass spectrometry.
Gupta A, Jansson B, Chatelain P, Massingham R, Hammarlund-Udenaes M. Gupta A, et al. Rapid Commun Mass Spectrom. 2005;19(12):1749-57. doi: 10.1002/rcm.1983. Rapid Commun Mass Spectrom. 2005. PMID: 15912525
Sensitive enantioselective liquid chromatographic assays using tandem mass spectrometric detection were developed and validated for the determination of S-cetirizine (S-CZE) and R-cetirizine (R-CZE) in guinea pig plasma, brain tissue, and microdialysis samples. ...F …
Sensitive enantioselective liquid chromatographic assays using tandem mass spectrometric detection were developed and validated for the dete …
Current Indications for Consideration of Evaluation for Hereditary Cancer Predisposition Syndromes and How They Can Change Management.
Massingham LJ, De Souza A. Massingham LJ, et al. R I Med J (2013). 2020 Apr 1;103(3):20-24. R I Med J (2013). 2020. PMID: 32236156 Free article.
Experimental design criteria in phylogenetics: where to add taxa.
Geuten K, Massingham T, Darius P, Smets E, Goldman N. Geuten K, et al. Syst Biol. 2007 Aug;56(4):609-22. doi: 10.1080/10635150701499563. Syst Biol. 2007. PMID: 17654365
R. Soc. Lond. B. 265: 1779-1786) thus allows investigation of "where to add taxa" in a phylogeny. We compare three different measures of the total information for selecting the position to add a taxon to a tree. ...
R. Soc. Lond. B. 265: 1779-1786) thus allows investigation of "where to add taxa" in a phylogeny. We compare three different measures
A new series of M3 muscarinic antagonists based on the 4-amino-piperidine scaffold.
Diouf O, Gadeau S, Chellé F, Gelbcke M, Talaga P, Christophe B, Gillard M, Massingham R, Guyaux M. Diouf O, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2535-9. doi: 10.1016/s0960-894x(02)00487-0. Bioorg Med Chem Lett. 2002. PMID: 12182854
Chemical modulations provided molecules with K(i) for the human M3-R up to 1 nM with variable selectivity (3- to 40-fold) over the human M2-R. ...
Chemical modulations provided molecules with K(i) for the human M3-R up to 1 nM with variable selectivity (3- to 40-fold) over the hu …
An in vitro investigation of the relationships between potency, lipophilicity, cytotoxicity and chemical class of representative calcium antagonist drugs.
John GW, Shrivastava R, Chevalier A, Pognat JF, Massingham R. John GW, et al. Pharmacol Res. 1993 Apr;27(3):253-62. doi: 10.1006/phrs.1993.1024. Pharmacol Res. 1993. PMID: 8327405
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