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Circulating miR-126 and miR-499 reflect progression of cardiovascular disease; correlations with uric acid and ejection fraction.
Khanaghaei M, Tourkianvalashani F, Hekmatimoghaddam S, Ghasemi N, Rahaie M, Khorramshahi V, Sheikhpour A, Heydari Z, Pourrajab F. Khanaghaei M, et al. Heart Int. 2016 Apr 26;11(1):e1-e9. doi: 10.5301/heartint.5000226. eCollection 2016 Jan-Dec. Heart Int. 2016. PMID: 27924211 Free PMC article.
RESULTS: Plasma concentrations of miRNAs were found to be significantly correlated with plasma levels of cardiac troponin I (cTnI) (miR-499, r 0.49, p~0.002; miR-126, r = 0.30, p~0.001), indicating cardiac damage. Data analysis revealed that miR-499 had higher sensi …
RESULTS: Plasma concentrations of miRNAs were found to be significantly correlated with plasma levels of cardiac troponin I (cTnI) (miR-499, …
Proteochemometrics modeling for prediction of the interactions between caspase isoforms and their inhibitors.
Bastami Z, Sheikhpour R, Razzaghi P, Ramazani A, Gharaghani S. Bastami Z, et al. Mol Divers. 2023 Feb;27(1):249-261. doi: 10.1007/s11030-022-10425-5. Epub 2022 Apr 19. Mol Divers. 2023. PMID: 35438428
Moreover, protein descriptors were computed using the Protr R package, while PADEL-Descriptor was employed for the computation of ligand descriptors. ...This study shows that the ensemble model demonstrates superior performance compared with other models in terms of R …
Moreover, protein descriptors were computed using the Protr R package, while PADEL-Descriptor was employed for the computation of lig …
A novel proteochemometrics model for predicting the inhibition of nine carbonic anhydrase isoforms based on supervised Laplacian score and k-nearest neighbour regression.
Nazarshodeh E, Sheikhpour R, Gharaghani S, Sarram MA. Nazarshodeh E, et al. SAR QSAR Environ Res. 2018 Jun;29(6):419-437. doi: 10.1080/1062936X.2018.1447995. Epub 2018 Jun 8. SAR QSAR Environ Res. 2018. PMID: 29882433
Statistical results (Q(2)(ext) = 0.7806, r(2)(test) = 0.7811 and RMSE(test) = 0.5549) showed that the model generated using SLS and KNN regression outperformed the other models. ...
Statistical results (Q(2)(ext) = 0.7806, r(2)(test) = 0.7811 and RMSE(test) = 0.5549) showed that the model generated using SLS and K …