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Efficient synthesis, spectral analysis and antimicrobial studies of nitrogen and sulfur containing spiro heterocycles from 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones.
Rani M, Ramachandran R, Kabilan S. Rani M, et al. Among authors: ramachandran r. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6637-43. doi: 10.1016/j.bmcl.2010.09.021. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20933408
From the NMR and Single crystal X-ray diffraction analysis, compounds 4b-4d, 4f-4h, 5b, 5c, 5f-5h, 6a, 7a and 7b were found to adopt twin-chair conformations whereas compounds 4a, 4e, 5a, 5d, 5e and 6b adopt chair and boat conformation of cyclohexane and piperidine rings, …
From the NMR and Single crystal X-ray diffraction analysis, compounds 4b-4d, 4f-4h, 5b, 5c, 5f-5h, 6a, 7a and 7b were found to adopt twin-ch …