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2010 683
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31,955 results

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The following term was not found in PubMed: Lu-Andrews
Page 1
Complementary functions for the Ran gradient during division.
Ozugergin I, Piekny A. Ozugergin I, et al. Small GTPases. 2021 May;12(3):177-187. doi: 10.1080/21541248.2020.1725371. Epub 2020 Feb 14. Small GTPases. 2021. PMID: 32013678 Free PMC article. Review.
The Ran pathway has a well-described function in nucleocytoplasmic transport, where active Ran dissociates importin/karyopherin-bound cargo containing a nuclear localization signal (NLS) in the nucleus. As cells enter mitosis, the nuclear envelope breaks down and a …
The Ran pathway has a well-described function in nucleocytoplasmic transport, where active Ran dissociates importin/karyopheri …
Inhibition of RAN attenuates influenza a virus replication and nucleoprotein nuclear export.
Cao L, She Z, Zhao Y, Cheng C, Li Y, Xu T, Mao H, Zhang Y, Hui X, Lin X, Wang T, Sun X, Huang K, Zhao L, Jin M. Cao L, et al. Emerg Microbes Infect. 2024 Dec;13(1):2387910. doi: 10.1080/22221751.2024.2387910. Epub 2024 Aug 12. Emerg Microbes Infect. 2024. PMID: 39087696 Free PMC article.
In the present study, we aimed to determine the function of RAN in influenza virus replication using different cell lines and subtype strains. We found that RAN is essential for the nuclear export of vRNP, as it enhances the binding affinity of XPO1 toward the viral …
In the present study, we aimed to determine the function of RAN in influenza virus replication using different cell lines and subtype …
Repeat-associated non-AUG (RAN) translation: insights from pathology.
Banez-Coronel M, Ranum LPW. Banez-Coronel M, et al. Lab Invest. 2019 Jul;99(7):929-942. doi: 10.1038/s41374-019-0241-x. Epub 2019 Mar 27. Lab Invest. 2019. PMID: 30918326 Free PMC article. Review.
Since the discovery of repeat-associated non-AUG (RAN) translation by Zu et al. in 2011, nine expansion disorders have been identified as RAN-positive diseases. ...In some diseases, RAN proteins have been shown to accumulate in affected brain regions. Here we …
Since the discovery of repeat-associated non-AUG (RAN) translation by Zu et al. in 2011, nine expansion disorders have been identifie …
Measuring Repeat-Associated Non-AUG (RAN) Translation.
Wang S, Sun S. Wang S, et al. Methods Mol Biol. 2022;2428:113-132. doi: 10.1007/978-1-0716-1975-9_8. Methods Mol Biol. 2022. PMID: 35171477
Many repeat expansion-containing RNAs can generate toxic repeat proteins through repeat-associated non-AUG (RAN) translation in all the reading frames. Understanding how RAN translation occurs and what cellular factors regulate this process will help decipher the ba …
Many repeat expansion-containing RNAs can generate toxic repeat proteins through repeat-associated non-AUG (RAN) translation in all t …
Repeat-associated non-ATG (RAN) translation.
Cleary JD, Pattamatta A, Ranum LPW. Cleary JD, et al. J Biol Chem. 2018 Oct 19;293(42):16127-16141. doi: 10.1074/jbc.R118.003237. Epub 2018 Sep 13. J Biol Chem. 2018. PMID: 30213863 Free PMC article.
These repeat expansion mutations can produce repeat-associated non-ATG (RAN) proteins in all three reading frames, which accumulate in disease-relevant tissues. ...Understanding how RAN translation occurs, what cellular factors contribute to RAN protein accum …
These repeat expansion mutations can produce repeat-associated non-ATG (RAN) proteins in all three reading frames, which accumulate i …
The Ran-GTPase and cell-cycle control.
Moore JD. Moore JD. Bioessays. 2001 Jan;23(1):77-85. doi: 10.1002/1521-1878(200101)23:1<77::AID-BIES1010>3.0.CO;2-E. Bioessays. 2001. PMID: 11135312 Review.
RCC1, the chromatin-bound guanine-nucleotide exchange factor (GEF) for the small nuclear GTPase, Ran, is required for coordinating the onset of mitosis with S-phase completion in mammalian cells. ...However, the Ran system is now best known for its pivotal role in n …
RCC1, the chromatin-bound guanine-nucleotide exchange factor (GEF) for the small nuclear GTPase, Ran, is required for coordinating th …
Ran GTPase: A Key Player in Tumor Progression and Metastasis.
Boudhraa Z, Carmona E, Provencher D, Mes-Masson AM. Boudhraa Z, et al. Front Cell Dev Biol. 2020 May 26;8:345. doi: 10.3389/fcell.2020.00345. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32528950 Free PMC article. Review.
Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state. ...The disruption of Ran expression has been linked to cancer at different levels - fro …
Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the GTPases, Ran cycles between an activ …
Ran at a glance.
Joseph J. Joseph J. J Cell Sci. 2006 Sep 1;119(Pt 17):3481-4. doi: 10.1242/jcs.03071. J Cell Sci. 2006. PMID: 16931595 Review. No abstract available.
Ran GTPase and Its Importance in Cellular Signaling and Malignant Phenotype.
El-Tanani M, Nsairat H, Mishra V, Mishra Y, Aljabali AAA, Serrano-Aroca Á, Tambuwala MM. El-Tanani M, et al. Int J Mol Sci. 2023 Feb 4;24(4):3065. doi: 10.3390/ijms24043065. Int J Mol Sci. 2023. PMID: 36834476 Free PMC article. Review.
In vitro, Ran overexpression has severe effects on the cell phenotype, altering proliferation, adhesion, colony density, and invasion. ...The increased malignancy and invasiveness have been attributed to multiple mechanisms. Increased dependence on Ran for spindle f …
In vitro, Ran overexpression has severe effects on the cell phenotype, altering proliferation, adhesion, colony density, and invasion …
Evolution and function of bacterial RCC1 repeat effectors.
Swart AL, Gomez-Valero L, Buchrieser C, Hilbi H. Swart AL, et al. Cell Microbiol. 2020 Oct;22(10):e13246. doi: 10.1111/cmi.13246. Epub 2020 Aug 26. Cell Microbiol. 2020. PMID: 32720355 Free article. Review.
NopA binds to Ran GTPase and promotes the nuclear accumulation of Ran(GTP), thus pertubing the import of the transcription factor NF-kappaB and innate immune signalling. Hence, divergent evolution of bacterial RCC1 repeat effectors defines the range of Ran GT …
NopA binds to Ran GTPase and promotes the nuclear accumulation of Ran(GTP), thus pertubing the import of the transcription fac …
31,955 results
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