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Biosynthesis of Largimycins in Streptomyces argillaceus Involves Transient β-Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family.
Becerril A, Pérez-Victoria I, Martín JM, Reyes F, Salas JA, Méndez C. Becerril A, et al. ACS Chem Biol. 2022 Aug 19;17(8):2320-2331. doi: 10.1021/acschembio.2c00416. Epub 2022 Jul 13. ACS Chem Biol. 2022. PMID: 35830174 Free PMC article.
Largimycins A1 and A2 are key members of a recently identified family of hybrid nonribosomal peptide polyketides belonging to the scarcely represented group of antitumor leinamycins. ...This cluster contains a halogenase gene and two sets of genes for the biosynthesis and …
Largimycins A1 and A2 are key members of a recently identified family of hybrid nonribosomal peptide polyketides belonging to the sca …
Infliximab in ulcerative colitis: real-life analysis of factors predicting treatment discontinuation due to lack of response or colectomy: ECIA (ACAD Colitis and Infliximab Study).
Fernández-Salazar L, Muñoz F, Barrio J, Muñoz C, Pajares R, Rivero M, Prieto V, Legido J, Bouhmidi A, Herranz M, Fernández N, Sánchez-Ocaña R, Joao D, Santos F. Fernández-Salazar L, et al. Scand J Gastroenterol. 2016;51(2):186-95. doi: 10.3109/00365521.2015.1070900. Epub 2015 Jul 22. Scand J Gastroenterol. 2016. PMID: 26200929