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1986 2
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43 results

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Page 1
Activated αβ T- and reduced mucosa-associated invariant T cells in LGI1- and CASPR2-encephalitis.
Esser D, Müller-Miny L, Heming M, Paunovic M, van Duijn M, Abrante Cabrera L, Mair KM, Strippel C, Räuber S, Dargvainiene J, Kovac S, Gross CC, Fransen N, van Steenhoven R, Körtvélyessy P, Stenzel W, Höftberger R, Bindels E, Bien CG, Wiendl H, Meuth SG, Bauer J, Melzer N, Titulaer MJ, Leypoldt F, Meyer Zu Hörste G; in cooperation with the EMC-AIE Study group. Esser D, et al. Brain. 2025 Mar 17:awaf096. doi: 10.1093/brain/awaf096. Online ahead of print. Brain. 2025. PMID: 40094812
Anti-Leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) autoimmune encephalitis (AIE) are common and characterized by pathogenic antibodies targeting neuronal autoantigens. ...
Anti-Leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) autoimmune encephalitis (AIE) are comm …
Modeling microbial growth and dynamics.
Esser DS, Leveau JH, Meyer KM. Esser DS, et al. Appl Microbiol Biotechnol. 2015 Nov;99(21):8831-46. doi: 10.1007/s00253-015-6877-6. Epub 2015 Aug 23. Appl Microbiol Biotechnol. 2015. PMID: 26298697 Review.
Future microbial growth models will likely become more complex to benefit from the rich toolbox that is now available to microbial growth modelers....
Future microbial growth models will likely become more complex to benefit from the rich toolbox that is now available to microbial gr …
PURA-Related Developmental and Epileptic Encephalopathy: Phenotypic and Genotypic Spectrum.
Johannesen KM, Gardella E, Gjerulfsen CE, Bayat A, Rouhl RPW, Reijnders M, Whalen S, Keren B, Buratti J, Courtin T, Wierenga KJ, Isidor B, Piton A, Faivre L, Garde A, Moutton S, Tran-Mau-Them F, Denommé-Pichon AS, Coubes C, Larson A, Esser MJ, Appendino JP, Al-Hertani W, Gamboni B, Mampel A, Mayorga L, Orsini A, Bonuccelli A, Suppiej A, Van-Gils J, Vogt J, Damioli S, Giordano L, Moortgat S, Wirrell E, Hicks S, Kini U, Noble N, Stewart H, Asakar S, Cohen JS, Naidu SR, Collier A, Brilstra EH, Li MH, Brew C, Bigoni S, Ognibene D, Ballardini E, Ruivenkamp C, Faggioli R, Afenjar A, Rodriguez D, Bick D, Segal D, Coman D, Gunning B, Devinsky O, Demmer LA, Grebe T, Pruna D, Cursio I, Greenhalgh L, Graziano C, Singh RR, Cantalupo G, Willems M, Yoganathan S, Góes F, Leventer RJ, Colavito D, Olivotto S, Scelsa B, Andrade AV, Ratke K, Tokarz F, Khan AS, Ormieres C, Benko W, Keough K, Keros S, Hussain S, Franques A, Varsalone F, Grønborg S, Mignot C, Heron D, Nava C, Isapof A, Borlot F, Whitney R, Ronan A, Foulds N, Somorai M, Brandsema J, Helbig KL, Helbig I, Ortiz-González XR, Dubbs H, Vitobello A, Anderson M, Spadafore D, Hunt D, Møller RS, Rubboli G; PURA study group. Johannesen KM, et al. Neurol Genet. 2021 Nov 15;7(6):e613. doi: 10.1212/NXG.0000000000000613. eCollection 2021 Dec. Neurol Genet. 2021. PMID: 34790866 Free PMC article.
BACKGROUND AND OBJECTIVES: Purine-rich element-binding protein A (PURA) gene encodes Pur-alpha, a conserved protein essential for normal postnatal brain development. ...
BACKGROUND AND OBJECTIVES: Purine-rich element-binding protein A (PURA) gene encodes Pur-alpha, a conserved protein essential for nor …
Amino Acid Substitution in the Cysteine-Rich Region of the Integrin beta4 Subunit Causes Late-Onset Mild Junctional Epidermolysis Bullosa without Extracutaneous Involvement.
Wang Y, Hotz A, Esser PR, Fischer J, Has C. Wang Y, et al. J Invest Dermatol. 2023 Nov;143(11):2233-2242.e3. doi: 10.1016/j.jid.2023.04.025. Epub 2023 May 19. J Invest Dermatol. 2023. PMID: 37211201 Free article.
In this study, we report a very rare subtype of late-onset, nonsyndromic JEB associated with a recurrent amino acid substitution in the highly conserved cysteine-rich tandem repeats of the integrin beta4 subunit. Literature review shows that among the patients diagnosed wi …
In this study, we report a very rare subtype of late-onset, nonsyndromic JEB associated with a recurrent amino acid substitution in the high …
Lytic archaeal viruses infect abundant primary producers in Earth's crust.
Rahlff J, Turzynski V, Esser SP, Monsees I, Bornemann TLV, Figueroa-Gonzalez PA, Schulz F, Woyke T, Klingl A, Moraru C, Probst AJ. Rahlff J, et al. Nat Commun. 2021 Jul 30;12(1):4642. doi: 10.1038/s41467-021-24803-4. Nat Commun. 2021. PMID: 34330907 Free PMC article.
Based on metagenomic information, we tag and image a putatively viral genome rich in protospacers using fluorescence microscopy. VirusFISH reveals a lytic lifestyle of the respective virus and challenges previous predictions that lysogeny prevails as the dominant viral lif …
Based on metagenomic information, we tag and image a putatively viral genome rich in protospacers using fluorescence microscopy. Viru …
An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis.
Schmitz K, Cox J, Esser LM, Voss M, Sander K, Löffler A, Hillebrand F, Erkelenz S, Schaal H, Kähne T, Klinker S, Zhang T, Nagel-Steger L, Willbold D, Seggewiß S, Schlütermann D, Stork B, Grimmler M, Wesselborg S, Peter C. Schmitz K, et al. Nucleic Acids Res. 2021 Jun 21;49(11):6437-6455. doi: 10.1093/nar/gkab452. Nucleic Acids Res. 2021. PMID: 34096600 Free PMC article.
The biogenesis of small uridine-rich nuclear ribonucleoproteins (UsnRNPs) depends on the methylation of Sm proteins catalyzed by the methylosome and the subsequent action of the SMN complex, which assembles the heptameric Sm protein ring onto small nuclear RNAs (snRNAs). . …
The biogenesis of small uridine-rich nuclear ribonucleoproteins (UsnRNPs) depends on the methylation of Sm proteins catalyzed by the …
NF90/NFAR (nuclear factors associated with dsRNA) - a new methylation substrate of the PRMT5-WD45-RioK1 complex.
Cox J, Esser LM, Jüdt M, Schmitz K, Reiffert K, Grimmler M, Stork B, Wesselborg S, Peter C. Cox J, et al. Biol Chem. 2022 Aug 31;403(10):907-915. doi: 10.1515/hsz-2022-0136. Print 2022 Sep 27. Biol Chem. 2022. PMID: 36040368 Free article.
We show for the first time that NF90 is symmetrically dimethylated by PRMT5 within the RG-rich region in its C-terminus. Since upregulation of PRMT5 is a hallmark of many cancer cells, the characterization of its dimethylation and modulation by specific commercial inhibito …
We show for the first time that NF90 is symmetrically dimethylated by PRMT5 within the RG-rich region in its C-terminus. Since upregu …
The Impact of p70S6 Kinase-Dependent Phosphorylation of Gemin2 in UsnRNP Biogenesis.
Esser LM, Li Q, Jüdt M, Kähne T, Stork B, Grimmler M, Wesselborg S, Peter C. Esser LM, et al. Int J Mol Sci. 2023 Oct 25;24(21):15552. doi: 10.3390/ijms242115552. Int J Mol Sci. 2023. PMID: 37958537 Free PMC article.
The survival motor neuron (SMN) complex is a multi-megadalton complex involved in post-transcriptional gene expression in eukaryotes via promotion of the biogenesis of uridine-rich small nuclear ribonucleoproteins (UsnRNPs). The functional center of the complex is formed f …
The survival motor neuron (SMN) complex is a multi-megadalton complex involved in post-transcriptional gene expression in eukaryotes via pro …
Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis.
Räuber S, Schroeter CB, Strippel C, Nelke C, Ruland T, Dik A, Golombeck KS, Regner-Nelke L, Paunovic M, Esser D, Münch C, Rosenow F, van Duijn M, Henes A, Ruck T, Amit I, Leypoldt F, Titulaer MJ, Wiendl H, Meuth SG, Meyer Zu Hörste G, Melzer N. Räuber S, et al. J Autoimmun. 2023 Feb;135:102985. doi: 10.1016/j.jaut.2022.102985. Epub 2023 Jan 6. J Autoimmun. 2023. PMID: 36621173 Free article.
Aiming to elucidate the pathophysiological mechanisms of AE, we applied an unsupervised proteomic approach to analyze the cerebrospinal fluid (CSF) protein profile of AE patients with autoantibodies against N-methyl-d-aspartate receptor (NMDAR) (n = 9), leucine-rich glioma …
Aiming to elucidate the pathophysiological mechanisms of AE, we applied an unsupervised proteomic approach to analyze the cerebrospinal flui …
SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.
Sertznig H, Roesmann F, Wilhelm A, Heininger D, Bleekmann B, Elsner C, Santiago M, Schuhenn J, Karakoese Z, Benatzy Y, Snodgrass R, Esser S, Sutter K, Dittmer U, Widera M. Sertznig H, et al. Front Immunol. 2022 Nov 15;13:935800. doi: 10.3389/fimmu.2022.935800. eCollection 2022. Front Immunol. 2022. PMID: 36458014 Free PMC article.
Efficient HIV-1 replication depends on balanced levels of host cell components including cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1-10). Type I interferons (IFN-I) play a crucial role in the innate immunity against HIV-1 by in …
Efficient HIV-1 replication depends on balanced levels of host cell components including cellular splicing factors as the family of serine/a …
43 results