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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1950 3
1951 4
1954 2
1955 2
1956 3
1958 1
1960 1
1962 1
1964 1
1965 3
1966 7
1967 3
1968 4
1969 4
1970 7
1971 6
1972 3
1973 5
1974 5
1975 3
1977 3
1978 1
1979 2
1980 3
1981 3
1982 3
1983 4
1984 2
1985 2
1986 3
1987 11
1988 10
1989 14
1990 16
1991 9
1992 19
1993 12
1994 28
1995 15
1996 15
1997 23
1998 54
1999 80
2000 70
2001 71
2002 98
2003 108
2004 114
2005 160
2006 176
2007 171
2008 149
2009 152
2010 155
2011 198
2012 210
2013 228
2014 311
2015 382
2016 420
2017 483
2018 634
2019 678
2020 840
2021 1038
2022 678
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Search Results

7,035 results
Results by year
Filters applied: . Clear all The following term was not found in PubMed: Silingiene
Page 1
RITA modulates cell migration and invasion by affecting focal adhesion dynamics.
Hoock SC, Ritter A, Steinhäuser K, Roth S, Behrends C, Oswald F, Solbach C, Louwen F, Kreis NN, Yuan J. Hoock SC, et al. Mol Oncol. 2019 Oct;13(10):2121-2141. doi: 10.1002/1878-0261.12551. Epub 2019 Aug 6. Mol Oncol. 2019. PMID: 31353815 Free PMC article.
Since RITA interacts with tubulin and coats microtubules of the cytoskeleton, we hypothesized that it is involved in cell motility. We show here that depletion of RITA reduces cell migration and invasion of diverse cancer cell lines and mouse embryonic fibroblasts. …
Since RITA interacts with tubulin and coats microtubules of the cytoskeleton, we hypothesized that it is involved in cell motility. W …
[Effect of RITA on TP53 Mutant Human Mantle Cell Lymphoma Cell Line and Its Mechanism].
Hua JY, Zhou XH, Wang Y, Xu B. Hua JY, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Dec;29(6):1780-1784. doi: 10.19746/j.cnki.issn.1009-2137.2021.06.015. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021. PMID: 34893110 Chinese.
The cells were treated by RITA (0-8 mumol/L) for 48 h, the cell apoptosis induced by RITA was detected by annexin V/PI flow cytometry. ...RITA could inhibit the proliferation of Mino cells significantly, and statistical analysis showed that the inhibition rat …
The cells were treated by RITA (0-8 mumol/L) for 48 h, the cell apoptosis induced by RITA was detected by annexin V/PI flow cy …
RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity.
Ristau J, van Hoef V, Peuget S, Zhu J, Guan BJ, Liang S, Hatzoglou M, Topisirovic I, Selivanova G, Larsson O. Ristau J, et al. Cell Death Dis. 2019 Nov 7;10(11):845. doi: 10.1038/s41419-019-2074-3. Cell Death Dis. 2019. PMID: 31699971 Free PMC article.
Yet, mechanisms underlying the anticancer activity of RITA are incompletely understood. Here we show that RITA suppresses mRNA translation independently of p53 by inducing eIF2alpha phosphorylation. ...Moreover, inhibition of eIF2alpha phosphorylation attenuates pro …
Yet, mechanisms underlying the anticancer activity of RITA are incompletely understood. Here we show that RITA suppresses mRNA …
Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy.
Peyser BD, Hermone A, Salamoun JM, Burnett JC, Hollingshead MG, McGrath CF, Gussio R, Wipf P. Peyser BD, et al. Mol Cancer Ther. 2019 Oct;18(10):1765-1774. doi: 10.1158/1535-7163.MCT-19-0185. Epub 2019 Jul 24. Mol Cancer Ther. 2019. PMID: 31341033 Free PMC article.
A selectivity index (SI) was developed to quantify this desirable feature, which is 20 for imatinib, whereas RITA's SI is only 0.10. One of the described hyperselective RITA analogs (SI = 7.9) completely lost activity in the presence of a known SULT1A1 inhibitor. Th …
A selectivity index (SI) was developed to quantify this desirable feature, which is 20 for imatinib, whereas RITA's SI is only 0.10. …
Looking at the future with Rita.
Bentivoglio M. Bentivoglio M. Neuroscience. 2013 Nov 12;252:438-42. doi: 10.1016/j.neuroscience.2013.08.013. Neuroscience. 2013. PMID: 24288808
This paper on Rita Levi-Montalcini (1909-2012), who received in 1986 the Nobel Prize in Physiology or Medicine for the discovery of nerve growth factor, focuses on aspects of her advocacy and her commitment to education in which she has been especially active in the last p …
This paper on Rita Levi-Montalcini (1909-2012), who received in 1986 the Nobel Prize in Physiology or Medicine for the discovery of n …
RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles.
Pietkiewicz AL, Zhang Y, Rahimi MN, Stramandinoli M, Teusner M, McAlpine SR. Pietkiewicz AL, et al. ACS Med Chem Lett. 2017 Mar 6;8(4):401-406. doi: 10.1021/acsmedchemlett.6b00488. eCollection 2017 Apr 13. ACS Med Chem Lett. 2017. PMID: 28435526 Free PMC article.
The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. ...Evaluating the impact of 7h on proteins targeted by RITA (p53, c-Myc, and Mcl-1) indicated that it acts via a different mechanism of action to that …
The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. ...Evaluating the …
Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis.
Kreis NN, Steinhäuser K, Ritter A, Klöble P, Hoock SC, Roth S, Louwen F, Oswald F, Yuan J. Kreis NN, et al. Oncogene. 2019 May;38(22):4199-4214. doi: 10.1038/s41388-019-0716-7. Epub 2019 Jan 31. Oncogene. 2019. PMID: 30705408
We asked if RITA could be related to the activation of Aurora A. We show here that RITA is colocalized with Aurora A and its activator TPX2 at spindle poles during mitosis. ...Depletion of RITA increases exclusively active Aurora A and TPX2 at spindle poles i …
We asked if RITA could be related to the activation of Aurora A. We show here that RITA is colocalized with Aurora A and its a …
Chk2 mediates RITA-induced apoptosis.
de Lange J, Verlaan-de Vries M, Teunisse AF, Jochemsen AG. de Lange J, et al. Cell Death Differ. 2012 Jun;19(6):980-9. doi: 10.1038/cdd.2011.182. Epub 2011 Dec 9. Cell Death Differ. 2012. PMID: 22158418 Free PMC article.
In addition, we observed an early p53- and Chk2-dependent block of DNA replication upon RITA treatment. Replicating cells seemed more prone to entering RITA-induced apoptosis. ...In conclusion, we identified Chk2 as an essential mediator of the cellular responses to …
In addition, we observed an early p53- and Chk2-dependent block of DNA replication upon RITA treatment. Replicating cells seemed more …
Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance.
Bu Y, Cai G, Shen Y, Huang C, Zeng X, Cao Y, Cai C, Wang Y, Huang D, Liao DF, Cao D. Bu Y, et al. Cancer Lett. 2016 Dec 28;383(2):261-271. doi: 10.1016/j.canlet.2016.10.006. Epub 2016 Oct 6. Cancer Lett. 2016. PMID: 27721021
A phosphomimetic mutation at Ser536 (p65/S536D) or silencing of endogenous RelA/p65 resensitized the RITA-resistant cells to RITA while the phosphomimetic mutant at Ser276 (p65/S276D) led to RITA resistance of naive cells. ...In the naive cells, ABCC6 deliver …
A phosphomimetic mutation at Ser536 (p65/S536D) or silencing of endogenous RelA/p65 resensitized the RITA-resistant cells to RITA
7,035 results