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Development of a Symptom-Focused Patient-Reported Outcome Measure for Functional Dyspepsia: The Functional Dyspepsia Symptom Diary (FDSD).
Taylor F, Higgins S, Carson RT, Eremenco S, Foley C, Lacy BE, Parkman HP, Reasner DS, Shields AL, Tack J, Talley NJ; Patient-Reported Outcome Consortiumʼs Functional Dyspepsia Working Group. Taylor F, et al. Am J Gastroenterol. 2018 Jan;113(1):39-48. doi: 10.1038/ajg.2017.265. Epub 2017 Sep 19. Am J Gastroenterol. 2018. PMID: 28925989 Free PMC article.
Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II).
York D, Baker J, Holder PG, Jones LC, Drake PM, Barfield RM, Bleck GT, Rabuka D. York D, et al. BMC Biotechnol. 2016 Feb 24;16:23. doi: 10.1186/s12896-016-0254-0. BMC Biotechnol. 2016. PMID: 26911368 Free PMC article.
The amount of copper required is compatible with large scale cell culture, as demonstrated in fed-batch cell cultures with antibody titers of 5 g . L(-1), specific cellular production rates of 75 pg . cell(-1) . d(-1), and fGly conversion yields of 95-98 %. ...
The amount of copper required is compatible with large scale cell culture, as demonstrated in fed-batch cell cultures with antibody titers o …