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2020 2
2022 5
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Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.
Brunetti L, Leuci R, Carrieri A, Catto M, Occhineri S, Vinci G, Gambacorta L, Baltrukevich H, Chaves S, Laghezza A, Altomare CD, Tortorella P, Santos MA, Loiodice F, Piemontese L. Brunetti L, et al. Among authors: leuci r. Eur J Med Chem. 2022 Jul 5;237:114358. doi: 10.1016/j.ejmech.2022.114358. Epub 2022 Apr 14. Eur J Med Chem. 2022. PMID: 35462163
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.
Sblano S, Cerchia C, Laghezza A, Piemontese L, Brunetti L, Leuci R, Gilardi F, Thomas A, Genovese M, Santi A, Tortorella P, Paoli P, Lavecchia A, Loiodice F. Sblano S, et al. Among authors: leuci r. Eur J Med Chem. 2022 May 5;235:114240. doi: 10.1016/j.ejmech.2022.114240. Epub 2022 Mar 16. Eur J Med Chem. 2022. PMID: 35325635