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Showing results for running zhu
Your search for Ruoning Zhu retrieved no results
Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice.
Zhang SS, Zhu L, Peng Y, Zhang L, Chao FL, Jiang L, Xiao Q, Liang X, Tang J, Yang H, He Q, Guo YJ, Zhou CN, Tang Y. Zhang SS, et al. J Neuroinflammation. 2022 Feb 5;19(1):34. doi: 10.1186/s12974-022-02401-5. J Neuroinflammation. 2022. PMID: 35123512 Free PMC article.
Running mice had free access to a running wheel for 3 months. Behavioral tests, [18]F-FDG-PET and hippocampal RNA-Seq were performed. ...The level of sTREM2 decreased in the plasma of APP/PS1 running mice. The number of microglia, the length and endpoints of …
Running mice had free access to a running wheel for 3 months. Behavioral tests, [18]F-FDG-PET and hippocampal RNA-Seq were per …
Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress.
Liu L, Tang J, Liang X, Li Y, Zhu P, Zhou M, Qin L, Deng Y, Li J, Wang Y, Jiang L, Huang D, Zhou Y, Wang S, Xiao Q, Luo Y, Tang Y. Liu L, et al. Mol Psychiatry. 2024 Jul;29(7):2031-2042. doi: 10.1038/s41380-024-02464-1. Epub 2024 Feb 15. Mol Psychiatry. 2024. PMID: 38361125
Running exercise has been shown to alleviate depressive symptoms. However, the mechanism underlying the antidepressant effects of running exercise is not fully understood. ...Together, these results suggest that running exercise maintains the M1/M2 balance an …
Running exercise has been shown to alleviate depressive symptoms. However, the mechanism underlying the antidepressant effects of …
Exercise maintains bone homeostasis by promoting osteogenesis through STAT3.
Huang X, Zhu Y, Sun S, Gao X, Yang Y, Xu H, Jin A, Liu Y, Jia H, Dai Q, Jiang L. Huang X, et al. Int J Biol Sci. 2023 Apr 2;19(7):2021-2033. doi: 10.7150/ijbs.82744. eCollection 2023. Int J Biol Sci. 2023. PMID: 37151888 Free PMC article.
However, the acting mechanism of mechanotransduction in bone remains unclear. We performed the running-wheel exercise and tail suspension model to study the effects of exercise on bone metabolism, and found that osteoblastic Signal transducer and activator of transcription …
However, the acting mechanism of mechanotransduction in bone remains unclear. We performed the running-wheel exercise and tail suspen …
Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis.
Chen X, Zhu X, Wei A, Chen F, Gao Q, Lu K, Jiang Q, Cao W. Chen X, et al. Bone Res. 2021 Feb 26;9(1):15. doi: 10.1038/s41413-020-00128-8. Bone Res. 2021. PMID: 33637693 Free PMC article.
Here, we report that epigenetic derepression of nuclear factor erythroid derived 2-related factor-2 (Nrf2), a master regulator of oxidative stress critically involved in the pathogenesis of OP, mediates the significant osteoprotective effects of running exercise (RE) in a …
Here, we report that epigenetic derepression of nuclear factor erythroid derived 2-related factor-2 (Nrf2), a master regulator of oxidative …
Long-term voluntary exercise inhibited AGE/RAGE and microglial activation and reduced the loss of dendritic spines in the hippocampi of APP/PS1 transgenic mice.
Wang YY, Zhou YN, Jiang L, Wang S, Zhu L, Zhang SS, Yang H, He Q, Liu L, Xie YH, Liang X, Tang J, Chao FL, Tang Y. Wang YY, et al. Exp Neurol. 2023 May;363:114371. doi: 10.1016/j.expneurol.2023.114371. Epub 2023 Mar 4. Exp Neurol. 2023. PMID: 36871860
Alzheimer's disease (AD) is closely related to hippocampal synapse loss, which can be alleviated by running exercise. However, further studies are needed to determine whether running exercise reduces synapse loss in the hippocampus in an AD model by regulating micro …
Alzheimer's disease (AD) is closely related to hippocampal synapse loss, which can be alleviated by running exercise. However, furthe …
Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction.
Zhou Q, Deng J, Yao J, Song J, Meng D, Zhu Y, Xu M, Liang Y, Xu J, Sluijter JP, Xiao J. Zhou Q, et al. EBioMedicine. 2021 Dec;74:103713. doi: 10.1016/j.ebiom.2021.103713. Epub 2021 Nov 24. EBioMedicine. 2021. PMID: 34837851 Free PMC article.
METHODS: HIPK2(-/-) mice and miR-222(-/-) rats, HIPK2 inhibitor (PKI1H) and adeno-associated virus serotype 9 (AAV9) carrying miR-222 were applied in the study. Animals were subjected to running, swimming, acute MI or post-MI remodeling. HIPK2 inhibition and P53 activator …
METHODS: HIPK2(-/-) mice and miR-222(-/-) rats, HIPK2 inhibitor (PKI1H) and adeno-associated virus serotype 9 (AAV9) carrying miR-222 were a …
Running exercise protects spinophilin-immunoreactive puncta and neurons in the medial prefrontal cortex of APP/PS1 transgenic mice.
Zhu L, Fan JH, Chao FL, Zhou CN, Jiang L, Zhang Y, Luo YM, Zhang L, Xiao Q, Yang H, Zhang SS, Wu H, Tang Y. Zhu L, et al. J Comp Neurol. 2022 Apr;530(6):858-870. doi: 10.1002/cne.25252. Epub 2021 Oct 20. J Comp Neurol. 2022. PMID: 34585379
In addition, running-induced improvements in spatial learning and memory were significantly associated with running-induced increases in spinophilin-immunoreactive puncta and neurons numbers in the mPFC. Running exercise could delay the loss of spinophilin-im …
In addition, running-induced improvements in spatial learning and memory were significantly associated with running-induced in …
A Novel Microcontroller-Based System for the Wheel-Running Activity in Mice.
Zhu M, Kasaragod DK, Kikutani K, Taguchi K, Aizawa H. Zhu M, et al. eNeuro. 2021 Nov 22;8(6):ENEURO.0260-21.2021. doi: 10.1523/ENEURO.0260-21.2021. Print 2021 Nov-Dec. eNeuro. 2021. PMID: 34479979 Free PMC article.
Voluntary wheel-running activity is a way to assess rodents' circadian rhythm and motivation for exercise. ...With the WRAQ, we can record the wheel-running activity and illumination data for at least 30 d. Applying the WRAQ to an endotoxemia mouse model robustly de …
Voluntary wheel-running activity is a way to assess rodents' circadian rhythm and motivation for exercise. ...With the WRAQ, we can r …
IMMerge: merging imputation data at scale.
Zhu W, Chen HH, Petty AS, Petty LE, Polikowsky HG, Gamazon ER, Below JE, Highland HM. Zhu W, et al. Bioinformatics. 2023 Jan 1;39(1):btac750. doi: 10.1093/bioinformatics/btac750. Bioinformatics. 2023. PMID: 36413071 Free PMC article.
To address these concerns, we developed IMMerge, a Python-based tool that takes advantage of multiprocessing to reduce running time. For the first time in a publicly available tool, imputation quality scores are correctly combined with Fisher's z transformation. ...
To address these concerns, we developed IMMerge, a Python-based tool that takes advantage of multiprocessing to reduce running time. …
The effects of voluntary running exercise on the astrocytes of the medial prefrontal cortex in APP/PS1 mice.
Liu M, Zhu L, Guo YJ, Zhang SS, Jiang L, Zhang Y, Chao FL, Tang Y. Liu M, et al. J Comp Neurol. 2023 Aug;531(11):1147-1162. doi: 10.1002/cne.25485. Epub 2023 May 5. J Comp Neurol. 2023. PMID: 37146123
Pathological changes in the medial prefrontal cortex (mPFC) and astrocytes are closely associated with Alzheimer's disease (AD). Voluntary running has been found to effectively delay AD. However, the effects of voluntary running on mPFC astrocytes in AD are unclear. …
Pathological changes in the medial prefrontal cortex (mPFC) and astrocytes are closely associated with Alzheimer's disease (AD). Voluntary …
648 results