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23,338 results

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Page 1
Adult hippocampal neurogenesis and its impairment in Alzheimer's disease.
Kim TA, Syty MD, Wu K, Ge S. Kim TA, et al. Zool Res. 2022 May 18;43(3):481-496. doi: 10.24272/j.issn.2095-8137.2021.479. Zool Res. 2022. PMID: 35503338 Free PMC article. Review.
Recent evidence suggests that adult hippocampal neurogenesis (AHN) persists throughout life in mammals, including humans. These newborn neurons have been implicated to have a crucial role in brain functions such as learning and memory. ...In this review, we summarized the …
Recent evidence suggests that adult hippocampal neurogenesis (AHN) persists throughout life in mammals, including humans. These newbo …
The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer's disease.
Geigenmüller JN, Tari AR, Wisloff U, Walker TL. Geigenmüller JN, et al. Alzheimers Dement. 2024 Oct;20(10):7369-7383. doi: 10.1002/alz.14179. Epub 2024 Aug 21. Alzheimers Dement. 2024. PMID: 39166771 Free PMC article. Review.
In this review we outline the regulation and function of AHN in healthy individuals, and highlight the relationship between AHN dysfunction and cognitive impairments in AD. ...Adult hippocampal neurogenesis is reduced in Alzheimer's disease in humans and anim …
In this review we outline the regulation and function of AHN in healthy individuals, and highlight the relationship between AHN …
Evidences for Adult Hippocampal Neurogenesis in Humans.
Moreno-Jiménez EP, Terreros-Roncal J, Flor-García M, Rábano A, Llorens-Martín M. Moreno-Jiménez EP, et al. J Neurosci. 2021 Mar 24;41(12):2541-2553. doi: 10.1523/JNEUROSCI.0675-20.2020. J Neurosci. 2021. PMID: 33762406 Free PMC article. Review.
This process, named adult hippocampal neurogenesis (AHN), is a striking form of neural plasticity that occurs in the brains of numerous mammalian species. Direct evidence of adult neurogenesis in humans has remained elusive, although the occurrence of this phenomenon in th …
This process, named adult hippocampal neurogenesis (AHN), is a striking form of neural plasticity that occurs in the brains of numero …
Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease.
Li YD, Luo YJ, Xie L, Tart DS, Sheehy RN, Zhang L, Coleman LG Jr, Chen X, Song J. Li YD, et al. Cell Stem Cell. 2023 Apr 6;30(4):415-432.e6. doi: 10.1016/j.stem.2023.02.006. Cell Stem Cell. 2023. PMID: 37028406 Free PMC article.
Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN can be enhanced in impaired AD brain to restore cognitive and affective function remains …
Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and anxiety, accompanied by impaired adult hippoc …
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.
Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. Choi SH, et al. Science. 2018 Sep 7;361(6406):eaan8821. doi: 10.1126/science.aan8821. Science. 2018. PMID: 30190379 Free PMC article.
Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer's disease (AD) pathology. We found that exercise provided cognitive benefit to 5 FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic f …
Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer's disease (AD) pathology. We found that exercis …
Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease.
Moreno-Jiménez EP, Flor-García M, Terreros-Roncal J, Rábano A, Cafini F, Pallas-Bazarra N, Ávila J, Llorens-Martín M. Moreno-Jiménez EP, et al. Nat Med. 2019 Apr;25(4):554-560. doi: 10.1038/s41591-019-0375-9. Epub 2019 Mar 25. Nat Med. 2019. PMID: 30911133
This process, called adult hippocampal neurogenesis (AHN), confers an unparalleled degree of plasticity to the entire hippocampal circuitry(3,4). ...These neurons exhibited variable degrees of maturation along differentiation stages of AHN. In sharp contrast, the nu …
This process, called adult hippocampal neurogenesis (AHN), confers an unparalleled degree of plasticity to the entire hippocampal cir …
Impact of neurodegenerative diseases on human adult hippocampal neurogenesis.
Terreros-Roncal J, Moreno-Jiménez EP, Flor-García M, Rodríguez-Moreno CB, Trinchero MF, Cafini F, Rábano A, Llorens-Martín M. Terreros-Roncal J, et al. Science. 2021 Nov 26;374(6571):1106-1113. doi: 10.1126/science.abl5163. Epub 2021 Oct 21. Science. 2021. PMID: 34672693 Free PMC article.
To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. ...Aging and neuro …
To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington's disease, …
Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression.
Zhang K, Wang F, Zhai M, He M, Hu Y, Feng L, Li Y, Yang J, Wu C. Zhang K, et al. Theranostics. 2023 Jan 22;13(3):1059-1075. doi: 10.7150/thno.81067. eCollection 2023. Theranostics. 2023. PMID: 36793868 Free PMC article.
Background: Depression is a mental disorder that poses a serious threat to human health. Adult hippocampal neurogenesis (AHN) is closely associated with the efficacy of antidepressants. Chronic treatment with corticosterone (CORT), a well-validated pharmacological stressor …
Background: Depression is a mental disorder that poses a serious threat to human health. Adult hippocampal neurogenesis (AHN) is clos …
Adult neurogenesis in Alzheimer's disease.
Choi SH, Tanzi RE. Choi SH, et al. Hippocampus. 2023 Apr;33(4):307-321. doi: 10.1002/hipo.23504. Epub 2023 Feb 7. Hippocampus. 2023. PMID: 36748337 Review.
Recent studies showed that AHN persists throughout life in humans, but it drops sharply in AD patients. Next questions to consider would be whether AHN impairment is a contributing factor to learning and memory impairment in AD and whether restoring AHN could …
Recent studies showed that AHN persists throughout life in humans, but it drops sharply in AD patients. Next questions to consider wo …
A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt/β-catenin signaling.
Tao W, Ruan J, Wu R, Zhao M, Zhao T, Qi M, Yau SSY, Yao G, Zhang H, Hu Y, Chen G. Tao W, et al. J Adv Res. 2023 Jan;43:219-231. doi: 10.1016/j.jare.2022.02.015. Epub 2022 Mar 2. J Adv Res. 2023. PMID: 36585110 Free PMC article.
Wnt/beta-catenin signaling was examined with western blot analysis. The role of AHN Wnt/beta-catenin cascade in crocin's antidepressant response was assessed by conditional removal of glial fibrillary acidic protein (GFAP)-expressing newborn neural cells, temozolomi …
Wnt/beta-catenin signaling was examined with western blot analysis. The role of AHN Wnt/beta-catenin cascade in crocin's antid …
23,338 results
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