Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia.
Kumowski N, Pabel S, Grune J, Momin N, Ninh VK, Stengel L, Mentkowski KI, Iwamoto Y, Zheng Y, Lee IH, Matthias J, Wirth JO, Pulous FE, Seung H, Paccalet A, Muse CG, Ting KKY, Delgado P, Lewis AJM, Kaushal V, Kreso A, Brown D, Hayat S, Kramann R, Swirski FK, Naxerova K, Propheter DC, Hooper LV, Moskowitz MA, King KR, Rosenthal N, Hulsmans M, Nahrendorf M.
Kumowski N, et al.
Science. 2025 Sep 4;389(6764):1043-1048. doi: 10.1126/science.adp7361. Epub 2025 Sep 4.
Science. 2025.
PMID: 40906843
Free PMC article.
Ventricular tachycardia disrupts the heart's coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrhythmias. ...
Ventricular tachycardia disrupts the heart's coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recru …