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Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
CRASH-2 trial collaborators; Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. CRASH-2 trial collaborators, et al. Lancet. 2010 Jul 3;376(9734):23-32. doi: 10.1016/S0140-6736(10)60835-5. Epub 2010 Jun 14. Lancet. 2010. PMID: 20554319 Clinical Trial.
Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017.
James SL, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, S Roberts NL, Sylte DO, Henry NJ, LeGrand KE, Abdelalim A, Abdoli A, Abdollahpour I, Abdulkader RS, Abedi A, Abosetugn AE, Abushouk AI, Adebayo OM, Agudelo-Botero M, Ahmad T, Ahmed R, Ahmed MB, Eddine Aichour MT, Alahdab F, Alamene GM, Alanezi FM, Alebel A, Alema NM, Alghnam SA, Al-Hajj S, Ali BA, Ali S, Alikhani M, Alinia C, Alipour V, Aljunid SM, Almasi-Hashiani A, Almasri NA, Altirkawi K, Abdeldayem Amer YS, Amini S, Loreche Amit AM, Andrei CL, Ansari-Moghaddam A, T Antonio CA, Yaw Appiah SC, Arabloo J, Arab-Zozani M, Arefi Z, Aremu O, Ariani F, Arora A, Asaad M, Asghari B, Awoke N, Ayala Quintanilla BP, Ayano G, Ayanore MA, Azari S, Azarian G, Badawi A, Badiye AD, Bagli E, Baig AA, Bairwa M, Bakhtiari A, Balachandran A, Banach M, Banerjee SK, Banik PC, Banstola A, Barker-Collo SL, Bärnighausen TW, Barrero LH, Barzegar A, Bayati M, Baye BA, Bedi N, Behzadifar M, Bekuma TT, Belete H, Benjet C, Bennett DA, Bensenor IM, Berhe K, Bhardwaj P, Bhat AG, Bhattacharyya K, Bibi S, Bijani A, Bin Sayeed MS, Borges G, Borzì AM, Boufous S, Brazinova A, Briko NI, Budhathoki SS, Car J, Cárdenas R, Carvalho F, Castaldelli-Maia JM, Cas… See abstract for full author list ➔ James SL, et al. Inj Prev. 2020 Oct;26(Supp 1):i96-i114. doi: 10.1136/injuryprev-2019-043494. Epub 2020 Apr 24. Inj Prev. 2020. PMID: 32332142 Free PMC article.
Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021.
GBD 2021 Global Subarachnoid Hemorrhage Risk Factors Collaborators; Rautalin I, Volovici V, Stark BA, Johnson CO, Kaprio J, Korja M, Krishnamurthi RV, Nair BS, Ranta A, Rinkel GJE, Vergouwen MDI, Abate YH, Abbastabar H, Abd-Allah F, Abdelkader A, Abdi P, Abdollahi A, Abdullahi A, Abiodun OO, Aboagye RG, Abouzid M, Abtahi D, Abu Rumeileh S, Abualhasan A, Abualruz H, Abukhadijah HJ, Abu-Zaid A, Adamu LH, Addo IY, Adedoyin RA, Adegboye OA, Adra S, Adzigbli LA, Agyemang-Duah W, Ahinkorah BO, Ahmad A, Ahmad D, Ahmadzade AM, Ahmed A, Ahmed H, Ahmed SA, Aji B, Akkaif MA, Al-Ajlouni Y, Al-Aly Z, Albashtawy M, Ali MU, Alif SM, Alimohamadi Y, Aljunid SM, Alomari MA, Alrawashdeh A, Alsabri MA, Salman RA, Altaf A, Al-Tammemi AB, Alvis-Guzman N, Alwafi H, Al-Wardat M, Al-Worafi YM, Aly H, Alyahya MSI, Alzoubi KH, Amani R, Amin TT, Amindarolzarbi A, Amusa GA, Anderlini D, Angappan D, Anil A, Anuoluwa BS, Anwar S, Anyasodor AE, Apostol GLC, Arabloo J, Areda D, Ärnlöv J, Artamonov AA, Artanti KD, Arumugam A, Aryan Z, Asghari-Jafarabadi M, Ashemo MY, Ashraf T, Athar M, Athari SS, Aujayeb A, Awotidebe AW, Azadnajafabad S, Aziz S, Azzam AY, Babu GR, Bagheri N, Bahrami Taghanaki P, Bahramian S, Bai R… See abstract for full author list ➔ GBD 2021 Global Subarachnoid Hemorrhage Risk Factors Collaborators, et al. JAMA Neurol. 2025 May 23. doi: 10.1001/jamaneurol.2025.1522. Online ahead of print. JAMA Neurol. 2025. PMID: 40406922
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
CRASH-2 collaborators; Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. CRASH-2 collaborators, et al. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. doi: 10.1016/S0140-6736(11)60278-X. Lancet. 2011. PMID: 21439633 Clinical Trial.