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Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State.
Compton JR, Mickey MJ, Hu X, Marugan JJ, Legler PM. Compton JR, et al. Biochemistry. 2017 Nov 28;56(47):6221-6230. doi: 10.1021/acs.biochem.7b00746. Epub 2017 Nov 9. Biochemistry. 2017. PMID: 29064679
Clan CN proteases contain a cysteine protease domain that is intimately packed with an S-adenosyl-l-methionine-dependent RNA methyltransferase (SAM MTase) domain. Within a cleft formed at the interface of these two domains, the peptide substrate is thought to bind. ...
Clan CN proteases contain a cysteine protease domain that is intimately packed with an S-adenosyl-l-methionine-dependent RNA methyltransfera …