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A novel co-processing method to manufacture an API for extended release formulation via formation of agglomerates of active ingredient and hydroxypropyl methylcellulose during crystallization.
Rosenbaum T, Erdemir D, Chang SY, Kientzler D, Wang S, Chan SH, Brown J, Hanley S, Kiang S. Rosenbaum T, et al. Among authors: kiang s. Drug Dev Ind Pharm. 2018 Oct;44(10):1606-1612. doi: 10.1080/03639045.2018.1483386. Epub 2018 Aug 14. Drug Dev Ind Pharm. 2018. PMID: 29916275