PRT3789 Is a First-in-Human SMARCA2-Selective Degrader That Induces Synthetic Lethality in SMARCA4-Mutated Cancers.
Hulse M, Wang M, Xu C, Carter J, Agarwal A, Lu L, Pitis P, Bhagwat N, Rager J, Kurian J, Basch C, Sivakumar M, Burtell J, Mondal A, Grego A, Moore A, Bachner C, Vykuntam K, Reichelderfer A, Park J, Cote J, Cowart M, Osinubi OP, Bigot L, Da Silva A, Nobre C, Meteau M, Soares M, Tang HY, Bersch K, Dai C, Cao G, Shen B, Emm T, Ruepp S, Xavier J, Tankersley C, Heiser D, Lee SH, Geeganage S, Ruggeri B, Lin H, Novotny W, Huang J, Vaddi K, Combs A, Scherle P, Ito K.
Hulse M, et al. Among authors: lee sh.
Cancer Res. 2026 Jan 2;86(1):213-235. doi: 10.1158/0008-5472.CAN-25-1141.
Cancer Res. 2026.
PMID: 40991405