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Silybins are stereospecific regulators of the 20S proteasome.
Persico M, García-Viñuales S, Santoro AM, Lanza V, Tundo GR, Sbardella D, Coletta M, Romanucci V, Zarrelli A, Di Fabio G, Fattorusso C, Milardi D. Persico M, et al. Among authors: garcia vinuales s. Bioorg Med Chem. 2022 Jul 15;66:116813. doi: 10.1016/j.bmc.2022.116813. Epub 2022 May 10. Bioorg Med Chem. 2022. PMID: 35576657
The change of conditions does not affect Ros87 downhill folding mechanism.
Grazioso R, García-Viñuales S, D'Abrosca G, Baglivo I, Pedone PV, Milardi D, Fattorusso R, Isernia C, Russo L, Malgieri G. Grazioso R, et al. Among authors: garcia vinuales s. Sci Rep. 2020 Dec 3;10(1):21067. doi: 10.1038/s41598-020-78008-8. Sci Rep. 2020. PMID: 33273582 Free PMC article.
Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins.
Sciacca MF, Lolicato F, Tempra C, Scollo F, Sahoo BR, Watson MD, García-Viñuales S, Milardi D, Raudino A, Lee JC, Ramamoorthy A, La Rosa C. Sciacca MF, et al. Among authors: garcia vinuales s. ACS Chem Neurosci. 2020 Dec 16;11(24):4336-4350. doi: 10.1021/acschemneuro.0c00588. Epub 2020 Dec 3. ACS Chem Neurosci. 2020. PMID: 33269918 Free PMC article.
Trehalose Conjugates of Silybin as Prodrugs for Targeting Toxic Aβ Aggregates.
García-Viñuales S, Ahmed R, Sciacca MFM, Lanza V, Giuffrida ML, Zimbone S, Romanucci V, Zarrelli A, Bongiorno C, Spinella N, Galati C, Di Fabio G, Melacini G, Milardi D. García-Viñuales S, et al. ACS Chem Neurosci. 2020 Sep 2;11(17):2566-2576. doi: 10.1021/acschemneuro.0c00232. Epub 2020 Aug 5. ACS Chem Neurosci. 2020. PMID: 32687307
17 results