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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 2
2002 10
2003 9
2004 5
2005 12
2006 5
2007 14
2008 7
2009 9
2010 9
2011 13
2012 11
2013 10
2014 14
2015 12
2016 15
2017 10
2018 14
2019 20
2020 8
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193 results
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Page 1
GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling.
Matsumoto S, Yamamichi T, Shinzawa K, Kasahara Y, Nojima S, Kodama T, Obika S, Takehara T, Morii E, Okuyama H, Kikuchi A. Matsumoto S, et al. Among authors: obika s. Nat Commun. 2019 Aug 28;10(1):3882. doi: 10.1038/s41467-019-11533-x. Nat Commun. 2019. PMID: 31462641 Free PMC article.
Evaluation of off-target effects of gapmer antisense oligonucleotides using human cells.
Yoshida T, Naito Y, Yasuhara H, Sasaki K, Kawaji H, Kawai J, Naito M, Okuda H, Obika S, Inoue T. Yoshida T, et al. Among authors: obika s. Genes Cells. 2019 Dec;24(12):827-835. doi: 10.1111/gtc.12730. Epub 2019 Nov 12. Genes Cells. 2019. PMID: 31637814 Free PMC article.
Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.
Uehara T, Choong CJ, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, Baba K, Nagata T, Yokota T, Tsuda H, Obika S, Mochizuki H. Uehara T, et al. Among authors: obika s. Sci Rep. 2019 May 21;9(1):7567. doi: 10.1038/s41598-019-43772-9. Sci Rep. 2019. PMID: 31110191 Free PMC article.
Highly efficient silencing of microRNA by heteroduplex oligonucleotides.
Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T. Yoshioka K, et al. Among authors: obika s. Nucleic Acids Res. 2019 Aug 22;47(14):7321-7332. doi: 10.1093/nar/gkz492. Nucleic Acids Res. 2019. PMID: 31214713 Free PMC article.
[Design of antisense oligonucleotides].
Obika S, Kasahara Y. Obika S, et al. Nihon Yakurigaku Zasshi. 2016 Aug;148(2):100-4. doi: 10.1254/fpj.148.100. Nihon Yakurigaku Zasshi. 2016. PMID: 27478049 Review. Japanese. No abstract available.
Synthesis of Monovalent N-Acetylgalactosamine Phosphoramidite for Liver-Targeting Oligonucleotides.
Yamamoto T, Terada C, Kashiwada K, Yamayoshi A, Harada-Shiba M, Obika S. Yamamoto T, et al. Among authors: obika s. Curr Protoc Nucleic Acid Chem. 2019 Sep;78(1):e99. doi: 10.1002/cpnc.99. Curr Protoc Nucleic Acid Chem. 2019. PMID: 31529782
DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing.
Nishina K, Piao W, Yoshida-Tanaka K, Sujino Y, Nishina T, Yamamoto T, Nitta K, Yoshioka K, Kuwahara H, Yasuhara H, Baba T, Ono F, Miyata K, Miyake K, Seth PP, Low A, Yoshida M, Bennett CF, Kataoka K, Mizusawa H, Obika S, Yokota T. Nishina K, et al. Among authors: obika s. Nat Commun. 2015 Aug 10;6:7969. doi: 10.1038/ncomms8969. Nat Commun. 2015. PMID: 26258894 Free PMC article.
Biological applications of xeno nucleic acids.
Morihiro K, Kasahara Y, Obika S. Morihiro K, et al. Among authors: obika s. Mol Biosyst. 2017 Jan 31;13(2):235-245. doi: 10.1039/c6mb00538a. Mol Biosyst. 2017. PMID: 27827481 Review.
Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth.
Harada T, Matsumoto S, Hirota S, Kimura H, Fujii S, Kasahara Y, Gon H, Yoshida T, Itoh T, Haraguchi N, Mizushima T, Noda T, Eguchi H, Nojima S, Morii E, Fukumoto T, Obika S, Kikuchi A. Harada T, et al. Among authors: obika s. Mol Cancer Ther. 2019 Mar;18(3):602-612. doi: 10.1158/1535-7163.MCT-18-0824. Epub 2019 Jan 15. Mol Cancer Ther. 2019. PMID: 30647122 Free article.
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