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The following term was not found in PubMed: Senming
Page 1
Did you mean deming tan (119 results)?
Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway.
Jiang Q, Chen X, Tian X, Zhang J, Xue S, Jiang Y, Liu T, Wang X, Sun Q, Hong Y, Li C, Guo D, Wang Y, Wang Q. Jiang Q, et al. Phytomedicine. 2022 Nov;106:154439. doi: 10.1016/j.phymed.2022.154439. Epub 2022 Sep 6. Phytomedicine. 2022. PMID: 36108374
However, the potential effects of Tan I against DOX-induced cardiotoxicity (DIC) have yet to be explored. PURPOSE: This study aimed to explore whether Tan I can protect against DIC and to reveal whether Tan I can exert anti-oxidative effect by regulating nucl …
However, the potential effects of Tan I against DOX-induced cardiotoxicity (DIC) have yet to be explored. PURPOSE: This study aimed t …
Targeting complement C3 with Tanshinone I decreases microglia-mediated synaptic engulfment to exert antidepressant effects.
Lai H, Fan P, Zhang P, Zhang M, Li X, Kuang B, Zhou R, Wang W, Jiang H, Wang Z, Chen N. Lai H, et al. Theranostics. 2025 Jul 24;15(16):8150-8175. doi: 10.7150/thno.115587. eCollection 2025. Theranostics. 2025. PMID: 40860146 Free PMC article.
However, the potential antidepressant effects of Tan I and the mechanism behind its action have yet to be established. Methods: The antidepressant effect of Tan I was evaluated using animal behavior tests. The chronic unpredictable stress (CUS) mice and C3 overexpre …
However, the potential antidepressant effects of Tan I and the mechanism behind its action have yet to be established. Methods: The a …
"Fake Tan" or "Fake News"?
Meyer G, Amano K, Xiao K, Wuerger S. Meyer G, et al. Iperception. 2020 Apr 11;11(2):2041669520915734. doi: 10.1177/2041669520915734. eCollection 2020 Mar-Apr. Iperception. 2020. PMID: 32313615 Free PMC article.
We estimated Trump's skin colour from 70 internet images and also from the "twitter tan line" image (February 8, 2020; Twitter). We then compared the estimated skin colours with two existing data sets of skin colours: the range of skin tans that occur naturally in the Cauc …
We estimated Trump's skin colour from 70 internet images and also from the "twitter tan line" image (February 8, 2020; Twitter). We t …
Nrf2-activated mitophagy and ferroptosis suppression synergistically mediate tangeretin's protection against hepatic ischemia-reperfusion injury.
Liu D, Zhang R, Zha L, Yao L, Han Y, Zhang X, Chen Y, Zhan M, Du J, Chen L. Liu D, et al. Phytomedicine. 2025 Sep;145:157034. doi: 10.1016/j.phymed.2025.157034. Epub 2025 Jul 1. Phytomedicine. 2025. PMID: 40617054
RESULTS: This study elucidated the protective mechanisms of TAN against hepatic I/R and OGD/R injury in primary hepatocytes. RNA-seq analysis indicated that TAN enhanced mitochondria-related biological functions, specifically mitophagy and ferroptosis. Our findings …
RESULTS: This study elucidated the protective mechanisms of TAN against hepatic I/R and OGD/R injury in primary hepatocytes. RNA-seq …
Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression.
Chen S, Li P, Shi K, Tang S, Zhang W, Peng C, Li T, Xie H, Liu C, Zhou J. Chen S, et al. Phytomedicine. 2025 Jun;141:156702. doi: 10.1016/j.phymed.2025.156702. Epub 2025 Apr 5. Phytomedicine. 2025. PMID: 40222167
RNA sequencing and public database analysis revealed that Tan IIA regulates PTGS2, the critical marker of ferroptosis, and PTGS2-knockdown attenuates Tan IIA -induced ferroptosis in melanoma cells. ...CONCLUSION: This study, the first to link Tan IIA-induced …
RNA sequencing and public database analysis revealed that Tan IIA regulates PTGS2, the critical marker of ferroptosis, and PTGS2-knoc …
Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis.
Yang C, Mu Y, Li S, Zhang Y, Liu X, Li J. Yang C, et al. Front Pharmacol. 2023 Dec 1;14:1321880. doi: 10.3389/fphar.2023.1321880. eCollection 2023. Front Pharmacol. 2023. PMID: 38108067 Free PMC article. Review.
In summary, Tan IIA improves AS through a complex pathway. We propose to further study the specific molecular targets of Tan IIA using systems biology methods, so as to fundamentally elucidate the mechanism of Tan IIA. It is worth mentioning that there is a l …
In summary, Tan IIA improves AS through a complex pathway. We propose to further study the specific molecular targets of Tan I …
Structural role of K224 in taniborbactam inhibition of NDM-1.
Ono D, Mojica MF, Bethel CR, Ishii Y, Drusin SI, Moreno DM, Vila AJ, Bonomo RA. Ono D, et al. Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0133223. doi: 10.1128/aac.01332-23. Epub 2024 Jan 4. Antimicrob Agents Chemother. 2024. PMID: 38174924 Free PMC article.
Kinetic assays with the K224I variant, the only variant with hydrolytic activity to FEP comparable to NDM-1, confirmed that the inhibitory capacity of TAN was modestly compromised (IC(50) 0.01 M vs 0.14 M for NDM-1). Lastly, structural modeling and docking simulations of …
Kinetic assays with the K224I variant, the only variant with hydrolytic activity to FEP comparable to NDM-1, confirmed that the inhibitory c …
Tanshinone IIA alleviate atherosclerosis and hepatic steatosis via down-regulation of MAPKs/NF-κB signaling pathway.
Zhang Y, Wang J, Yang S, Kou H, Liu P. Zhang Y, et al. Int Immunopharmacol. 2025 Apr 16;152:114465. doi: 10.1016/j.intimp.2025.114465. Epub 2025 Mar 15. Int Immunopharmacol. 2025. PMID: 40090083
The study aims to explore the mechanisms underlying the anti-atherosclerosis and anti-hepatic steatosis effects of Tan IIA. METHODS: The LDLR(-/-)mice were divided into control, model, low/high Tan IIA and atorvastatin group, which fed with High-fat diet to build NA …
The study aims to explore the mechanisms underlying the anti-atherosclerosis and anti-hepatic steatosis effects of Tan IIA. METHODS: …
Tanshinone IIA reduces tubulointerstitial fibrosis by suppressing GSDMD-mediated pyroptosis.
Yang X, Luo Q, Wu Z, Wang C, Yang Y, Zheng L, Li K, Zhao L, Jurong Y. Yang X, et al. Pharm Biol. 2025 Dec;63(1):364-373. doi: 10.1080/13880209.2025.2498166. Epub 2025 May 7. Pharm Biol. 2025. PMID: 40331369 Free PMC article.
MATERIALS AND METHODS: Gasdermin D (GSDMD) knockout mice and their wild-type (WT) littermates underwent UUO surgery, with Tan IIA treatment administered 24 h prior. Human proximal tubular cells (HK-2 cells) were treated with TGF-beta1 to induce fibrosis (50 ng/mL for 24 h) …
MATERIALS AND METHODS: Gasdermin D (GSDMD) knockout mice and their wild-type (WT) littermates underwent UUO surgery, with Tan IIA tre …
Tanshinone I alleviates post-ischemic myocardial injury by targeting TGFBR1 and modulating the TGF-β signaling pathway.
Ke L, Zheng Z, Ye S, Zhong C, Lin Q, Hu Y, Shi P, Wen L, Yao H. Ke L, et al. Phytomedicine. 2025 Sep;145:156994. doi: 10.1016/j.phymed.2025.156994. Epub 2025 Jun 16. Phytomedicine. 2025. PMID: 40580691
PURPOSE: Systematic evaluation of the role of Tan I in reducing myocardial ischemia (MI) injury and elucidation of the underlying molecular mechanisms by which Tan I improves myocardial fibrosis and ventricular function in mouse MI models. ...MD simulations, CETSA, …
PURPOSE: Systematic evaluation of the role of Tan I in reducing myocardial ischemia (MI) injury and elucidation of the underlying mol …
191,468 results
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