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Showing results for sigma dolin
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Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands.
Mercer SL, Shaikh J, Traynor JR, Matsumoto RR, Coop A. Mercer SL, et al. Eur J Med Chem. 2008 Jun;43(6):1304-8. doi: 10.1016/j.ejmech.2007.09.026. Epub 2007 Oct 6. Eur J Med Chem. 2008. PMID: 17988766 Free PMC article.
A series of N-substituted-4-cyano-4-phenylpiperidine analogs were synthesized and evaluated for binding affinity at opioid receptors and showed no affinity. The series similarity to previously reported sigma ligands prompted analysis at sigma receptors to determine …
A series of N-substituted-4-cyano-4-phenylpiperidine analogs were synthesized and evaluated for binding affinity at opioid receptors and sho …
Population pharmacokinetic analysis of didanosine (2',3'-dideoxyinosine) plasma concentrations obtained in phase I clinical trials in patients with AIDS or AIDS-related complex.
Pai SM, Shukla UA, Grasela TH, Knupp CA, Dolin R, Valentine FT, McLaren C, Liebman HA, Martin RR, Pittman KA, et al. Pai SM, et al. J Clin Pharmacol. 1992 Mar;32(3):242-7. doi: 10.1002/j.1552-4604.1992.tb03832.x. J Clin Pharmacol. 1992. PMID: 1564128 Clinical Trial.
Interindividual variability (omega) was (%CV) 22.3 and 71.0 for CL and Vc, respectively. Intraindividual (residual) variability (sigma) in plasma concentrations (%CV) was 50.2. Body weight, sex, and age did not account for the variability in either CL or Vc, and the use of …
Interindividual variability (omega) was (%CV) 22.3 and 71.0 for CL and Vc, respectively. Intraindividual (residual) variability (sigma …
Morphine discrimination in the pigeon using a color tracking procedure.
Paule MG, Wenger GR. Paule MG, et al. Pharmacol Biochem Behav. 1986 Mar;24(3):597-604. doi: 10.1016/0091-3057(86)90564-2. Pharmacol Biochem Behav. 1986. PMID: 3703895
Pretreatment with 1.0 mg/kg naloxone shifted the morphine generalization curve 10-fold to the right but only shifted the rate suppression curve 3-fold to the right. dl-Cyclazocine generated dose-related increases in responding on the red key location and in 3 of 5 birds, response …
Pretreatment with 1.0 mg/kg naloxone shifted the morphine generalization curve 10-fold to the right but only shifted the rate suppression cu …
Discriminative stimulus properties of nalorphine in the rhesus monkeys.
Tang AH, Code RA. Tang AH, et al. J Pharmacol Exp Ther. 1983 Dec;227(3):563-9. J Pharmacol Exp Ther. 1983. PMID: 6317838
The kappa opiate agonists, ethylketocyclazocine, U-50,488, bremazocine, tifluadom, as well as two mixed kappa-sigma agonists, dl-cyclazocine and dl-N-allylnormetazocine (SKF-10047), generalized to nalorphine with the following potency ranking order: bremazocine greater tha …
The kappa opiate agonists, ethylketocyclazocine, U-50,488, bremazocine, tifluadom, as well as two mixed kappa-sigma agonists, dl-cycl …