Age-related epithelial defects limit thymic function and regeneration.
Kousa AI, Jahn L, Zhao K, Flores AE, Acenas D 2nd, Lederer E, Argyropoulos KV, Lemarquis AL, Granadier D, Cooper K, D'Andrea M, Sheridan JM, Tsai J, Sikkema L, Lazrak A, Nichols K, Lee N, Ghale R, Malard F, Andrlova H, Velardi E, Youssef S, Burgos da Silva M, Docampo M, Sharma R, Mazutis L, Wimmer VC, Rogers KL, DeWolf S, Gipson B, Gomes ALC, Setty M, Pe'er D, Hale L, Manley NR, Gray DHD, van den Brink MRM, Dudakov JA.
Kousa AI, et al.
Nat Immunol. 2024 Sep;25(9):1593-1606. doi: 10.1038/s41590-024-01915-9. Epub 2024 Aug 7.
Nat Immunol. 2024.
PMID: 39112630
Free PMC article.
Interaction analysis revealed that the emergence of aaTECs drew tonic signals from other functional TEC populations at baseline acting as a sink for TEC growth factors. Following acute injury, aaTECs expanded substantially, further perturbing trophic regeneration pathways …
Interaction analysis revealed that the emergence of aaTECs drew tonic signals from other functional TEC populations at baseline acting as a …