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Showing results for simian qin
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Divergent Simian Arteriviruses Cause Simian Hemorrhagic Fever of Differing Severities in Macaques.
Wahl-Jensen V, Johnson JC, Lauck M, Weinfurter JT, Moncla LH, Weiler AM, Charlier O, Rojas O, Byrum R, Ragland DR, Huzella L, Zommer E, Cohen M, Bernbaum JG, Caì Y, Sanford HB, Mazur S, Johnson RF, Qin J, Palacios GF, Bailey AL, Jahrling PB, Goldberg TL, O'Connor DH, Friedrich TC, Kuhn JH. Wahl-Jensen V, et al. mBio. 2016 Feb 23;7(1):e02009-15. doi: 10.1128/mBio.02009-15. mBio. 2016. PMID: 26908578 Free PMC article.
Simian hemorrhagic fever (SHF) is a highly lethal disease in captive macaques. ...SHF is caused by at least three viruses of the family Arteriviridae: simian hemorrhagic fever virus (SHFV), simian hemorrhagic encephalitis virus (SHEV), and Pebjah virus (PBJV)
Simian hemorrhagic fever (SHF) is a highly lethal disease in captive macaques. ...SHF is caused by at least three viruses of the fami
Therapeutic Efficacy and Resistance Selection of a Lipopeptide Fusion Inhibitor in Simian Immunodeficiency Virus-Infected Rhesus Macaques.
Yu D, Xue J, Wei H, Cong Z, Chen T, Zhu Y, Chong H, Wei Q, Qin C, He Y. Yu D, et al. J Virol. 2020 Jul 16;94(15):e00384-20. doi: 10.1128/JVI.00384-20. Print 2020 Jul 16. J Virol. 2020. PMID: 32404526 Free PMC article.
We recently reported a group of lipopeptide-based membrane fusion inhibitors with potent antiviral activities against human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV). In this study, the in vivo therapeutic efficacy of such a lipo …
We recently reported a group of lipopeptide-based membrane fusion inhibitors with potent antiviral activities against human immunodeficiency …
Development of broad neutralization activity in simian/human immunodeficiency virus-infected rhesus macaques after long-term infection.
Gao N, Wang W, Wang C, Gu T, Guo R, Yu B, Kong W, Qin C, Giorgi EE, Chen Z, Townsley S, Hu SL, Yu X, Gao F. Gao N, et al. AIDS. 2018 Mar 13;32(5):555-563. doi: 10.1097/QAD.0000000000001724. AIDS. 2018. PMID: 29239895
However, whether broadly neutralizing antibodies (bnAbs) can be elicited in NHPs infected with simian/human immunodeficiency virus (SHIV) has not been fully understood. ...
However, whether broadly neutralizing antibodies (bnAbs) can be elicited in NHPs infected with simian/human immunodeficiency virus (S …
Recombinant Human Interleukin-15 and Anti-PD-L1 Combination Therapy Expands a CXCR3+PD1-/low CD8 T-Cell Subset in Simian Immunodeficiency Virus-Infected Rhesus Macaques.
Chen P, Chen H, Moussa M, Cheng J, Li T, Qin J, Lifson JD, Sneller MC, Krymskaya L, Godin S, Lane HC, Catalfamo M. Chen P, et al. J Infect Dis. 2020 Feb 3;221(4):523-533. doi: 10.1093/infdis/jiz485. J Infect Dis. 2020. PMID: 31562760 Free PMC article.
BACKGROUND: The PD1/PD-L1 pathway contributes to the pathogenesis of human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection, and blockade of this pathway may have potential to restore immune function and promote viral control or elimination. ...
BACKGROUND: The PD1/PD-L1 pathway contributes to the pathogenesis of human immunodeficiency virus (HIV)/simian immunodeficiency virus …
Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection.
Wu Y, Xue J, Wang C, Li W, Wang L, Chen W, Prabakaran P, Kong D, Jin Y, Hu D, Wang Y, Lei C, Yu D, Tu C, Bardhi A, Sidorov I, Ma L, Goldstein H, Qin C, Lu L, Jiang S, Dimitrov DS, Ying T. Wu Y, et al. J Virol. 2019 Sep 30;93(20):e01077-19. doi: 10.1128/JVI.01077-19. Print 2019 Oct 15. J Virol. 2019. PMID: 31375583 Free PMC article.
However, while a number of HIV-1 broadly neutralizing antibodies (bnAbs) have demonstrated remarkable efficacy as prophylaxis in macaques chronically infected with simian-human immunodeficiency virus (SHIV), intriguingly, their inhibitory effects were largely attenuated in …
However, while a number of HIV-1 broadly neutralizing antibodies (bnAbs) have demonstrated remarkable efficacy as prophylaxis in macaques ch …
A simian-human immunodeficiency virus carrying the rt gene from Chinese CRF01_AE strain of HIV is sensitive to nucleoside reverse transcriptase inhibitors and has a highly genetic stability in vivo.
Wang W, Yao N, Ju B, Dong Z, Cong Z, Jiang H, Qin C, Wei Q. Wang W, et al. Microbes Infect. 2014 Jun;16(6):461-71. doi: 10.1016/j.micinf.2014.03.008. Epub 2014 Apr 5. Microbes Infect. 2014. PMID: 24709063
However, its drug resistance, associated mutations, and viral fitness have not been systemically studied, because available chimeric simian-HIVs (SHIVs) usually express the HIV-1 reverse transcriptase (rt) gene of subtype B HIV-1, which is different from subtype CRF01_AE H …
However, its drug resistance, associated mutations, and viral fitness have not been systemically studied, because available chimeric simi
Simian immunodeficiency virus infection potently modulates chemokine networks and immune environments in hilar lymph nodes of cynomolgus macaques.
Qin S, Junecko BA, Lucero CM, Klamar CR, Trichel AM, Murphey-Corb MA, Tarwater PM, Kirschner DE, Reinhart TA. Qin S, et al. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):428-37. doi: 10.1097/QAI.0b013e31828ac85f. J Acquir Immune Defic Syndr. 2013. PMID: 23429503 Free PMC article.
BACKGROUND: Chemokines provide critical immune cell homing and activation signals that if altered could affect the inflammatory milieu and cellular composition of lymphoid tissues. During HIV-1 and simian immunodeficiency virus (SIV)-infection, the virus triggers an increa …
BACKGROUND: Chemokines provide critical immune cell homing and activation signals that if altered could affect the inflammatory milieu and c …
Structural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus.
Chong H, Zhu Y, Yu D, He Y. Chong H, et al. J Virol. 2018 Sep 26;92(20):e01088-18. doi: 10.1128/JVI.01088-18. Print 2018 Oct 15. J Virol. 2018. PMID: 30089693 Free PMC article.
Chong, J. Xue, Y. Zhu, Z. Cong, T. Chen, Y. Guo, Q. Wei, Y. Zhou, C. Qin, Y. He, 2018, J Virol 92:e00775-18, https://doi.org/10.1128/JVI.00775-18). ...Fourth, while LP-52 showed the most potent activity in inhibiting divergent HIV-1 subtypes, its truncated versions, such a …
Chong, J. Xue, Y. Zhu, Z. Cong, T. Chen, Y. Guo, Q. Wei, Y. Zhou, C. Qin, Y. He, 2018, J Virol 92:e00775-18, https://doi.org/10.1128/ …
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.
Fan J, Liang H, Ji X, Wang S, Xue J, Li D, Peng H, Qin C, Yee C, Shao Y. Fan J, et al. Nat Commun. 2019 May 21;10(1):2257. doi: 10.1038/s41467-019-09725-6. Nat Commun. 2019. PMID: 31113957 Free PMC article.
Here, we evaluate the use of adoptively transferred HIV vaccine-induced subtype C Env-specific CTLs in a macaque subtype B simian-human immunodeficiency virus (SHIV) model to determine whether plasma viremia can be controlled after ART interruption. ...
Here, we evaluate the use of adoptively transferred HIV vaccine-induced subtype C Env-specific CTLs in a macaque subtype B simian-hum …
62 results