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Discovery of Novel Inhibitors of a Critical Brain Enzyme Using a Homology Model and a Deep Convolutional Neural Network.

Stecula A, Hussain MS, Viola RE. Stecula A, et al. J Med Chem. 2020 Aug 27;63(16):8867-8875. doi: 10.1021/acs.jmedchem.0c00473. Epub 2020 Jul 30. J Med Chem. 2020. PMID: 32787146

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Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.

Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML, Giacomini KM. Yee SW, et al. Among authors: stecula a. FASEB J. 2020 Dec;34(12):15734-15752. doi: 10.1096/fj.202001497R. Epub 2020 Oct 30. FASEB J. 2020. PMID: 33124720 Free PMC article.

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Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.

Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM. Zou L, et al. Among authors: stecula a. J Pharm Sci. 2021 Jan;110(1):347-353. doi: 10.1016/j.xphs.2020.09.004. Epub 2020 Sep 7. J Pharm Sci. 2021. PMID: 32910949 Free PMC article.

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A phosphotyrosine switch regulates organic cation transporters.

Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JHM, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N. Sprowl JA, et al. Among authors: stecula a. Nat Commun. 2016 Mar 16;7:10880. doi: 10.1038/ncomms10880. Nat Commun. 2016. PMID: 26979622 Free PMC article.

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Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.

Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM. Zou L, et al. Among authors: stecula a. Mol Pharmacol. 2018 Jul;94(1):689-699. doi: 10.1124/mol.117.111153. Epub 2018 May 2. Mol Pharmacol. 2018. PMID: 29720497 Free PMC article.

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Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.

Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C. Yee SW, et al. Among authors: stecula a. J Hum Genet. 2013 Jun;58(6):353-61. doi: 10.1038/jhg.2013.38. Epub 2013 May 16. J Hum Genet. 2013. PMID: 23677058 Free PMC article.

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Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer.

Stecula A, Schlessinger A, Giacomini KM, Sali A. Stecula A, et al. Biochemistry. 2017 Jul 11;56(27):3475-3483. doi: 10.1021/acs.biochem.7b00339. Epub 2017 Jun 29. Biochemistry. 2017. PMID: 28661652 Free PMC article.

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Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).

Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM. Chen EC, et al. Among authors: stecula a. J Med Chem. 2017 Apr 13;60(7):2685-2696. doi: 10.1021/acs.jmedchem.6b01317. Epub 2017 Mar 15. J Med Chem. 2017. PMID: 28230985 Free article.

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The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment.

Tran TH, Nguyen JV, Stecula A, Akutagawa J, Moorman AV, Braun BS, Sali A, Mullighan CG, Shah NP, Dai Y, Devidas M, Roberts KG, Smith CC, Loh ML. Tran TH, et al. Among authors: stecula a. Haematologica. 2021 Aug 1;106(8):2242-2245. doi: 10.3324/haematol.2020.261354. Haematologica. 2021. PMID: 33626861 Free PMC article. No abstract available.

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Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM. Yee SW, et al. Among authors: stecula a. PLoS Genet. 2019 Sep 25;15(9):e1008208. doi: 10.1371/journal.pgen.1008208. eCollection 2019 Sep. PLoS Genet. 2019. PMID: 31553721 Free PMC article.

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