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1985 2
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1987 3
1988 1
1989 2
1990 2
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1994 2
1996 2
1997 1
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2000 3
2001 5
2002 3
2003 4
2004 1
2005 6
2006 5
2007 3
2008 5
2009 3
2010 4
2011 4
2012 2
2013 7
2014 5
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2016 13
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2019 15
2020 12
2021 15
2022 11
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Showing results for step knowles
Search for Steph Knowles instead (2 results)
One-Step Generation of Multisomes from Lipid-Stabilized Double Emulsions.
Czekalska MA, Jacobs AMJ, Toprakcioglu Z, Kong L, Baumann KN, Gang H, Zubaite G, Ye R, Mu B, Levin A, Huck WTS, Knowles TPJ. Czekalska MA, et al. ACS Appl Mater Interfaces. 2021 Feb 10;13(5):6739-6747. doi: 10.1021/acsami.0c16019. Epub 2021 Feb 1. ACS Appl Mater Interfaces. 2021. PMID: 33522221
Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis.
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS). International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS). Mol Psychiatry. 2018 May;23(5):1181-1188. doi: 10.1038/mp.2017.154. Epub 2017 Aug 1. Mol Psychiatry. 2018. PMID: 28761083 Free PMC article.
This joint analysis constituting the largest single OCD genome-wide study to date represents a major integrative step in elucidating the genetic causes of OCD....
This joint analysis constituting the largest single OCD genome-wide study to date represents a major integrative step in elucidating …
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
Savage JE, Jansen PR, Stringer S, Watanabe K, Bryois J, de Leeuw CA, Nagel M, Awasthi S, Barr PB, Coleman JRI, Grasby KL, Hammerschlag AR, Kaminski JA, Karlsson R, Krapohl E, Lam M, Nygaard M, Reynolds CA, Trampush JW, Young H, Zabaneh D, Hägg S, Hansell NK, Karlsson IK, Linnarsson S, Montgomery GW, Muñoz-Manchado AB, Quinlan EB, Schumann G, Skene NG, Webb BT, White T, Arking DE, Avramopoulos D, Bilder RM, Bitsios P, Burdick KE, Cannon TD, Chiba-Falek O, Christoforou A, Cirulli ET, Congdon E, Corvin A, Davies G, Deary IJ, DeRosse P, Dickinson D, Djurovic S, Donohoe G, Conley ED, Eriksson JG, Espeseth T, Freimer NA, Giakoumaki S, Giegling I, Gill M, Glahn DC, Hariri AR, Hatzimanolis A, Keller MC, Knowles E, Koltai D, Konte B, Lahti J, Le Hellard S, Lencz T, Liewald DC, London E, Lundervold AJ, Malhotra AK, Melle I, Morris D, Need AC, Ollier W, Palotie A, Payton A, Pendleton N, Poldrack RA, Räikkönen K, Reinvang I, Roussos P, Rujescu D, Sabb FW, Scult MA, Smeland OB, Smyrnis N, Starr JM, Steen VM, Stefanis NC, Straub RE, Sundet K, Tiemeier H, Voineskos AN, Weinberger DR, Widen E, Yu J, Abecasis G, Andreassen OA, Breen G, Christiansen L, Debrabant B, Dick DM, Heinz A, Hjerling-Leffler J, Ikram MA, Kendler KS, Martin NG, Medland SE, Pedersen NL, Plomin R, Polderman TJC, Ripke S, van der Sluis S, Sullivan PF, Vrieze SI, Wright MJ, Posthuma D. Savage JE, et al. Nat Genet. 2018 Jul;50(7):912-919. doi: 10.1038/s41588-018-0152-6. Epub 2018 Jun 25. Nat Genet. 2018. PMID: 29942086 Free PMC article.
We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. …
We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest …
Pd-Catalyzed Cascade Reactions of Aziridines: One-Step Access to Complex Tetracyclic Amines.
Knowles JP, Steeds HG, Schwarz M, Latter F, Booker-Milburn KI. Knowles JP, et al. Org Lett. 2021 Jun 16;23(13):4986-90. doi: 10.1021/acs.orglett.1c01403. Online ahead of print. Org Lett. 2021. PMID: 34132553 Free PMC article.
The combination of palladium catalysis and thermal cycloaddition is shown to transform tricyclic aziridines into complex, stereodefined tetracyclic products in a single step. This highly unusual cascade process involves a diverted Tsuji-Trost sequence leading to a surprisi …
The combination of palladium catalysis and thermal cycloaddition is shown to transform tricyclic aziridines into complex, stereodefined tetr …
Identifying Microbiome-Mediated Behaviour in Wild Vertebrates.
Davidson GL, Raulo A, Knowles SCL. Davidson GL, et al. Trends Ecol Evol. 2020 Nov;35(11):972-980. doi: 10.1016/j.tree.2020.06.014. Epub 2020 Jul 28. Trends Ecol Evol. 2020. PMID: 32736804 Review.
We outline a toolkit of approaches that could be applied in this endeavour and argue that beyond collecting observational data on the microbiome and behaviour from free-living animals, the incorporation of manipulative approaches tailored to such systems will be a key next ste
We outline a toolkit of approaches that could be applied in this endeavour and argue that beyond collecting observational data on the microb …
Evolution of Enzyme Function and the Development of Catalytic Efficiency: Triosephosphate Isomerase, Jeremy R. Knowles, and W. John Albery.
Gerlt JA. Gerlt JA. Biochemistry. 2021 Nov 23;60(46):3529-3538. doi: 10.1021/acs.biochem.1c00211. Epub 2021 May 20. Biochemistry. 2021. PMID: 34015914
This Perspective reminds readers that the first free-energy profile determined for an enzyme-catalyzed reaction, that for triosephosphate isomerase, was published in Biochemistry in 1976 by Jeremy R. Knowles, W. John Albery, and co-workers. They used the profile to propose …
This Perspective reminds readers that the first free-energy profile determined for an enzyme-catalyzed reaction, that for triosephosphate is …
Feedback control of protein aggregation.
Dear AJ, Michaels TCT, Knowles TPJ, Mahadevan L. Dear AJ, et al. J Chem Phys. 2021 Aug 14;155(6):064102. doi: 10.1063/5.0055925. J Chem Phys. 2021. PMID: 34391352
We find that treatment timing, duration, and drug dosage all depend strongly on the particular reaction step being targeted. Moreover, for some kinds of inhibitory drugs, the optimal regimen exhibits high sensitivity to stochastic fluctuations. ...
We find that treatment timing, duration, and drug dosage all depend strongly on the particular reaction step being targeted. Moreover …
Statins and hearing.
Whitlon DS. Whitlon DS. Hear Res. 2022 Jan 31:108453. doi: 10.1016/j.heares.2022.108453. Online ahead of print. Hear Res. 2022. PMID: 35125240 Review.
Statins are a class of drugs that are widely used for the treatment of hyperlipidemia and the prevention of heart attack and stroke. These drugs inhibit the rate-limiting step in the synthesis of cholesterol, HMG-CoA reductase. In addition, statins have effects unrelated t …
Statins are a class of drugs that are widely used for the treatment of hyperlipidemia and the prevention of heart attack and stroke. These d …
Biomembranes in bioelectronic sensing.
Jayaram AK, Pappa AM, Ghosh S, Manzer ZA, Traberg WC, Knowles TPJ, Daniel S, Owens RM. Jayaram AK, et al. Trends Biotechnol. 2022 Jan;40(1):107-123. doi: 10.1016/j.tibtech.2021.06.001. Epub 2021 Jul 3. Trends Biotechnol. 2022. PMID: 34229865 Review.
Of particular interest are conducting polymers, a class of electroactive polymers, which have the potential to create the next step-change for bioelectronics devices. Lastly, we discuss the impact these types of devices could have for biomedical applications....
Of particular interest are conducting polymers, a class of electroactive polymers, which have the potential to create the next step-c …
Genetic influence on cognitive development between childhood and adulthood.
Mollon J, Knowles EEM, Mathias SR, Gur R, Peralta JM, Weiner DJ, Robinson EB, Gur RE, Blangero J, Almasy L, Glahn DC. Mollon J, et al. Mol Psychiatry. 2021 Feb;26(2):656-665. doi: 10.1038/s41380-018-0277-0. Epub 2018 Oct 19. Mol Psychiatry. 2021. PMID: 30644433 Free PMC article.
Establishing significant Gene Age interactions in neurocognitive functions across childhood and early adulthood is a necessary first step in identifying genes that influence cognitive development, rather than genes that influence cognition per se. ...
Establishing significant Gene Age interactions in neurocognitive functions across childhood and early adulthood is a necessary first step
177 results