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Adenosine and Its Receptors: An Expected Tool for the Diagnosis and Treatment of Coronary Artery and Ischemic Heart Diseases.
Gaudry M, Vairo D, Marlinge M, Gaubert M, Guiol C, Mottola G, Gariboldi V, Deharo P, Sadrin S, Maixent JM, Fenouillet E, Ruf J, Guieu R, Paganelli F. Gaudry M, et al. Int J Mol Sci. 2020 Jul 27;21(15):5321. doi: 10.3390/ijms21155321. Int J Mol Sci. 2020. PMID: 32727116 Free PMC article. Review.
Among them, A(2) subtypes are strongly expressed in coronary tissues, and their activation increases coronary blood flow via the production of cAMP in smooth muscle cells. A(2A) receptor modulators are an opportunity for intense research by the pharmaceutical industry to d …
Among them, A(2) subtypes are strongly expressed in coronary tissues, and their activation increases coronary blood flow via the production …
Roles and regulation of the transcription factor CREB in pancreatic β -cells.
Dalle S, Quoyer J, Varin E, Costes S. Dalle S, et al. Curr Mol Pharmacol. 2011 Nov;4(3):187-95. doi: 10.2174/1874467211104030187. Curr Mol Pharmacol. 2011. PMID: 21488836 Review.
The preservation of a functional pancreatic beta-cell mass has become a major point of research in type 2 diabetes (T2D) and the future therapies of T2D notably aim at protecting the beta-cell from dysfunction and apoptotic death. beta-cell proliferation, survival and insulin sec …
The preservation of a functional pancreatic beta-cell mass has become a major point of research in type 2 diabetes (T2D) and the future ther …
Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic β-cell impairments in type 2 diabetes.
Dalle S, Burcelin R, Gourdy P. Dalle S, et al. Cell Signal. 2013 Feb;25(2):570-9. doi: 10.1016/j.cellsig.2012.11.009. Epub 2012 Nov 15. Cell Signal. 2013. PMID: 23159576 Review.
We discuss the possibility that production of signaling molecules, such as cAMP, generated into the beta-cells by native GLP-1 or pharmacological GLP-1 analogs may vary and engage different downstream signaling networks. ...
We discuss the possibility that production of signaling molecules, such as cAMP, generated into the beta-cells by native GLP-1 or pha …
Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors.
Allart-Simon I, Moniot A, Bisi N, Ponce-Vargas M, Audonnet S, Laronze-Cochard M, Sapi J, Hénon E, Velard F, Gérard S. Allart-Simon I, et al. RSC Med Chem. 2021 Mar 1;12(4):584-592. doi: 10.1039/d0md00423e. eCollection 2021 Apr 28. RSC Med Chem. 2021. PMID: 34046629 Free PMC article.
Cyclic nucleotide phosphodiesterase type 4 (PDE4), which controls the intracellular level of cyclic adenosine monophosphate (cAMP), has aroused scientific attention as a suitable target for anti-inflammatory therapy of respiratory diseases. ...
Cyclic nucleotide phosphodiesterase type 4 (PDE4), which controls the intracellular level of cyclic adenosine monophosphate (cAMP), h …
Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents.
Barberot C, Moniot A, Allart-Simon I, Malleret L, Yegorova T, Laronze-Cochard M, Bentaher A, Médebielle M, Bouillon JP, Hénon E, Sapi J, Velard F, Gérard S. Barberot C, et al. Eur J Med Chem. 2018 Feb 25;146:139-146. doi: 10.1016/j.ejmech.2018.01.035. Epub 2018 Jan 17. Eur J Med Chem. 2018. PMID: 29407945
Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. ...
Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientifi …
A critical role for Dop1-mediated dopaminergic signaling in the plasticity of behavioral and neuronal responses to sex pheromone in a moth.
Gassias E, Durand N, Demondion E, Bourgeois T, Aguilar P, Bozzolan F, Debernard S. Gassias E, et al. J Exp Biol. 2019 Nov 29;222(Pt 23):jeb211979. doi: 10.1242/jeb.211979. J Exp Biol. 2019. PMID: 31704905
We cloned A. ipsilon Dop1 (AiDop1), which is expressed predominantly in brain and especially in ALs; its knockdown induced a decrease in AL cAMP and altered sex pheromone-orientated flight. The levels of DA, AiDop1 expression and cAMP in ALs increased from the third …
We cloned A. ipsilon Dop1 (AiDop1), which is expressed predominantly in brain and especially in ALs; its knockdown induced a decrease in AL …
Role of the initiator element in the regulation of the melanoma cell adhesion molecule gene.
Karlen S, Braathen LR. Karlen S, et al. J Invest Dermatol. 2000 Oct;115(4):668-73. doi: 10.1046/j.1523-1747.2000.00100.x. J Invest Dermatol. 2000. PMID: 10998141 Free article.
The pyrimidine-rich CTCACTTG initiator, which overlaps the RNA start site, was essential for promoter function and was shown to interact with proteins related to basic helix-loop-helix transcription factors. Binding in nonmetastatic melanoma cells was induced by cAMP. In m …
The pyrimidine-rich CTCACTTG initiator, which overlaps the RNA start site, was essential for promoter function and was shown to interact wit …