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The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates.

Vaughn JP, Creacy SD, Routh ED, Joyner-Butt C, Jenkins GS, Pauli S, Nagamine Y, Akman SA. Vaughn JP, et al. Among authors: akman sa. J Biol Chem. 2005 Nov 18;280(46):38117-20. doi: 10.1074/jbc.C500348200. Epub 2005 Sep 7. J Biol Chem. 2005. PMID: 16150737 Free article.

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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1.

Routh ED, Creacy SD, Beerbower PE, Akman SA, Vaughn JP, Smaldino PJ. Routh ED, et al. Among authors: akman sa. J Vis Exp. 2017 Mar 18;(121):55496. doi: 10.3791/55496. J Vis Exp. 2017. PMID: 28362374 Free PMC article.

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G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates.

Creacy SD, Routh ED, Iwamoto F, Nagamine Y, Akman SA, Vaughn JP. Creacy SD, et al. Among authors: akman sa. J Biol Chem. 2008 Dec 12;283(50):34626-34. doi: 10.1074/jbc.M806277200. Epub 2008 Oct 7. J Biol Chem. 2008. PMID: 18842585 Free PMC article.

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Mutagenicity of ochratoxin A and its hydroquinone metabolite in the SupF gene of the mutation reporter plasmid Ps189.

Akman SA, Adams M, Case D, Park G, Manderville RA. Akman SA, et al. Toxins (Basel). 2012 Apr;4(4):267-80. doi: 10.3390/toxins4040267. Epub 2012 Apr 16. Toxins (Basel). 2012. PMID: 22606376 Free PMC article.

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Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective.

Chifman J, Arat S, Deng Z, Lemler E, Pino JC, Harris LA, Kochen MA, Lopez CF, Akman SA, Torti FM, Torti SV, Laubenbacher R. Chifman J, et al. Among authors: akman sa. PLoS Comput Biol. 2017 Feb 6;13(2):e1005352. doi: 10.1371/journal.pcbi.1005352. eCollection 2017 Feb. PLoS Comput Biol. 2017. PMID: 28166223 Free PMC article.

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Fatty acid metabolites in rapidly proliferating breast cancer.

O'Flaherty JT, Wooten RE, Samuel MP, Thomas MJ, Levine EA, Case LD, Akman SA, Edwards IJ. O'Flaherty JT, et al. Among authors: akman sa. PLoS One. 2013 May 2;8(5):e63076. doi: 10.1371/journal.pone.0063076. Print 2013. PLoS One. 2013. PMID: 23658799 Free PMC article.

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Detection and characterization of a glutathione conjugate of ochratoxin A.

Dai J, Park G, Wright MW, Adams M, Akman SA, Manderville RA. Dai J, et al. Among authors: akman sa. Chem Res Toxicol. 2002 Dec;15(12):1581-8. doi: 10.1021/tx0255929. Chem Res Toxicol. 2002. PMID: 12482240

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Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding.

Smaldino PJ, Routh ED, Kim JH, Giri B, Creacy SD, Hantgan RR, Akman SA, Vaughn JP. Smaldino PJ, et al. Among authors: akman sa. PLoS One. 2015 Jul 14;10(7):e0132668. doi: 10.1371/journal.pone.0132668. eCollection 2015. PLoS One. 2015. PMID: 26172836 Free PMC article.

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Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells.

Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN. Swanner J, et al. Among authors: akman sa. Int J Nanomedicine. 2015 Jun 11;10:3937-53. doi: 10.2147/IJN.S80349. eCollection 2015. Int J Nanomedicine. 2015. PMID: 26185437 Free PMC article.

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G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA.

Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. Giri B, et al. Among authors: akman sa. Nucleic Acids Res. 2011 Sep 1;39(16):7161-78. doi: 10.1093/nar/gkr234. Epub 2011 May 17. Nucleic Acids Res. 2011. PMID: 21586581 Free PMC article.

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